1.The effect of right heart load changing on electrophysiological parameters in anesthetized dogs
Hanying QIU ; Haiyu WANG ; Dijun LI ; Huanyuan MAO
Chinese Journal of Pathophysiology 1986;0(01):-
AIM:To study the effects of changing right heart load on electrophysiologic parameters in anesthetized dogs. METHODS:Change of right atrial and ventricular load, right atrial and ventricular diastolic threshold (ADT, VDT), right atrial and ventricular relative refractory period (ARRP,VRRP) and right atrial and ventricular effective refractory period (AERP, VERP) were recorded. RESULTS: Increasing right heart load step by step(grade A and B) caused prolongation of ARRP, AERP, VRRP (grade B, P
2.Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy.
Qiufen WANG ; Yuhua LIAO ; Feili GONG ; Huanyuan MAO ; Jinzhi ZHANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(3):231-245
To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%, P < 0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors.
Adult
;
Autoantibodies
;
immunology
;
Cardiomyopathy, Dilated
;
genetics
;
immunology
;
Female
;
HLA-DR Antigens
;
genetics
;
immunology
;
HLA-DRB1 Chains
;
Humans
;
Male
;
Middle Aged
;
Mitochondria, Heart
;
immunology
;
Mitochondrial ADP, ATP Translocases
;
immunology