1.Phenotypic and genetic analysis of acute megakaryoblastic leukemia in young children with WT1, MLL-PTD and EVI1 genes.
Liping ZHAO ; Xing CHEN ; Manjiang LI ; Huanliang DENG
Chinese Journal of Medical Genetics 2021;38(7):690-693
OBJECTIVE:
To explore the phenotypic and genetic characteristics of acute megakaryoblastic leukemia (AMKL) in young children accompany by WT1, MLL-PTD and EVI1, in order to improve the diagnosis level of AMKL.
METHODS:
EDTA-K
RESULTS:
White blood cell count was 12.3× 10
CONCLUSION
Acute megakaryocytic leukemia has unique and complex phenotypic and genetics characteristics.
Bone Marrow
;
Child
;
Child, Preschool
;
Chromosome Aberrations
;
Humans
;
Karyotyping
;
Leukemia, Megakaryoblastic, Acute/genetics*
;
MDS1 and EVI1 Complex Locus Protein
;
Megakaryocytes
;
Oncogene Proteins, Fusion
;
WT1 Proteins