Objective To assess the effects of very-low-carbohydrate diet (VLCD) on body function and body composition in obese or overweight subjects.Methods Thirty five overweight or obese subjects were enrolled in the study,including 10 males and 25 females with a mean age of (43 ± 10) years.All subjects received VLCD intervention and 30 min moderate-intensity exercise daily for 3 months.The height,weight,blood pressure,heart rate,blood lipids and body composition were measured before and 1,3 months after intervention.ANOVA or nonparametric test was used for statistical analysis.Results After 3-month intervention,compared to baseline,the average body weight was decreased by 17.2 and 5.9 kg,waist circumference was decreased by 15.1 and 4.5 cm,BMI index decreased by 4.3 and 3.4 kg/cm2,waist to hip ratio was decreased by 0.1 and 0.1,for males and females,respectively (F =11.65 and 5.28,8.36 and 3.73,9.28 and 12.06,3.32 and 19.43,all P ＜ 0.05).Compared with the baseline,the systolic pressure was decreased by 12.2 and 9.2 mmHg(1 mmHg =0.133 kPa),triglycerides were decreased by 0.25 and 0.42 mmol/L,fasting blood glucose was decreased by 0.13 and 0.43 mmol/L after 1 month and 3 months of intervention,respectively.The proportion of patients with fatty liver was decreased from 69％ (24/35) at baseline to 49％ (17/35) at 1 month after intervention and further to 6％ (2/32) at 3 months after intervention (x2 =27.52,P ＜ 0.05).Conclusion The results indicate that VLCD can effectively control the body weight,and significantly improve the state of body function disorder.

To investigate the association between Helicobacter pylori ( Hp ) infection and type 2 diabetes.Total 4 129 health check up subjects aged (49.1 ±11.3) years (18-92 years), including 2 649 males and 1 480 females were enrolled in this cross-section study.Hp infection was confirmed by 13 C-urea breath test;type 2 diabetes mellitus was diagnosed according to WHO criteria (1999).Single factor analysis and multiple regression analysis were used to evaluate the association between Hp affection and the prevalence of type 2 diabetes.Hp infection rate in diabetic group was significantly higher than that in non-diabetic group (45.6%vs.39.0%, P<0.05).Hp infection rate in subjects with newly diagnosed diabetes was highest than those with previously diagnosed diabetes and non-diabetic subjects ( P<0.05).The glycosylated hemoglobin level in Hp infection group was higher than that in non infection group [ ( 5.88 ±0.64 )% vs.( 5.62 ± 0.88)%, P<0.05];the fasting plasma glucose and postprandial blood glucose levels in Hp infection group were also higher than those in non-infection group ( P<0.05 ).Logistic regression analysis showed that Hp infection was one of the independent risk factors of type 2 diabetes (OR=2.002, 95%CI:1.564-2.563, P<0.05).The study indicates that Hp infection is closely associated with type 2 diabetes mellitus.

Objective To investigate blood uric acid levels in health check-up receivers in Tianjin City. Methods Blood uric acid levels in 28 661 health check-up participants were tested and the incidence of hyperuricaemia was analyzed. Blood pressure, body mass index, blood sugar, cholesterol and triglyceride were measured and compared. Results The average level of blood uric acid was (349±73 ) μ mol/L in male,and (256±59) μmol/L in female. The peak value in male was found in the 30 to 39 years old group,while in female the age was increased to 70 years old. The incidence of hyperuricaemia was higher in male ( 15. 2% vs 6. 3% ,P＜0.01). The level of blood sugar,triglycerides and total cholesterol was higher in the hyperuricaemia group. Also in the hyperuricaemia group, the incidence of overweight/obesity,hyperglycaemia, hyperlipidemia and hypertension was higher. Conclusions The incidence of hyperuricaemia in routine health check-up individuals in Tianjin City could be 11.3%. Blood uric acid may be significantly associated with metabolism.