Objective:To analyze the significance of empowerment intervention for main caregivers of stomach neoplasm patients undergoing chemotherapy on fear of cancer recurrence, psychological capital.Methods:Using convenient sampling method, the 90 patients with stomach neoplasm treated with chemotherapy from January to December 2021 were randomly divided into control group (45 cases) and observation group (45 cases), and one main caregiver was selected for each patient.The control group was given the routine nursing scheme of stomach neoplasm patients undergoing chemotherapy, and the observation group was given the intervention mode of empowering the main caregivers on the basis of the routine nursing scheme of stomach neoplasm chemotherapy. The fear of cancer recurrence, psychological capital and quality of life of the two groups before intervention and after three chemotherapy cycles were statistically compared by using the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Positive Psychological Capital Questionnaire (PPQ) and Functional Assessment of Cancer Thearpy-General model(FACT-G).Results:Finally 44 cases in the observation group and 43 cases in the control group were included. The total scores of FCR, PPQ and FACT-G in the observation group were (39.7 ± 3.2), (112.8 ± 16.9), (84.2 ± 9.1) points before intervention respectively, and(31.1 ± 2.5), (134.7 ± 15.6), (94.1 ± 9.6) points after intervention respectively.The differences were statistically significant( t=20.02, 8.94, 7.02, all P<0.05). The total score of FCR in the observation group was significantly lower than that in the control group after intervention, which were (31.1 ± 2.5) points and (37.7 ± 2.8) points respectively, the difference was statistically significant ( t=11.60, P<0.05). The total score of PPQ in the observation group was (134.7 ± 15.6) points after intervention, which was significantly higher than that in the control group (114.8 ± 15.8) points after intervention, the difference was statistically significant ( t=5.91, P<0.05). The total FACT-G score of the observation group was (94.1 ± 9.6) points, which was higher than that of the control group (86.5 ± 9.0) points, the difference was statistically significant ( t=3.81, P<0.05). Conclusions:The implementation of empowerment intervention for main caregivers of stomach neoplasm patients undergoing chemotherapy can reduce the fear of cancer recurrence, improve psychological capital, and improve the quality of life.