Objective To explore the influence of atorvastatin on neurological function of patients with progressive cerebral infarction.Methods 80 patients with cerebral infarction were randomly divided into two groups,40 cases in the control group using conventional treatment,the observation group 40 cases on the basis of control group combined with atorvastatin treatment.Two groups of clinical data were retrospectively analyzed.Results Two groups of neural function defect score before treatment had no significant difference,after treatment,observation group scored significantly higher than that of control group,the difference was statistically significant (P ＜ 0.05).The observation group 40 cases,23 cases were cured,57.5％ ; 10 cases,accounting for 25.0％ ; effective 5 cases,accounting for 12.5％,2 cases are invalid,accounted for 5.0％,the total clinical efficiency of 95.0％.40 cases in the control group,9 cases were cured,22.5％ ;9 cases,accounting for 22.5 ％ ; effective in 10 cases,accounting for 25.0％,12,30.0％.The total efficiency was 70.0％.The total efficiency of observation group was better than that of the control group,the difference was statistically significant (P ＜ 0.05).Conclusion The progress of cerebral infarction patients in the conventional anticoagulation plus atorvastatin,which can maximize the protection of nerve function,improve the clinical cure rate and improve the life quality of the patients.

Objective To investigate the feasibility of different doses of dexmedetomidine required to prevent sufentanil-induced cough during anesthesia induction. Methods Two hundred and forty ASA Ⅰ or Ⅱ patients, aged 18-55 yr, weighing 45-78 kg, undergoing elective gynecological operations under general anaesthesia, were randomly divided into 4 groups ( n = 60 each) : Ⅰ -Ⅳ groups. Ⅱ -Ⅳ groups received iv infusion of dexmedetomidine 0.10, 0.25 and 0.50 fig/kg at a rate of 0.05 μg·kg-1·min-1 respectively before anesthesia induction. Anesthesia was induced with target-controlled infusion of propofol (target effect-site concentration 5 μg/ml) , when the BIS value reached 55, iv sufentanil 0.5 fig/kg was injected over 3 s. The occurrence and degree of cough were recorded within 1 min after sufentanil injection. Tracheal intubation was facilitated with succinylcholine 1-2 mg/kg after the observation. The adverse cardiovascular events (severe sinus bradycardia, hypotension) were also record ed from the start of dexmedetomidine infusion to 1 min after intubation. Results The incidences of cough were 25 % , 7 % , 7 % and 5 % , incidences of severe sinus bradycardia 0, 3 % , 15 % and 25 % , and incidences of hypotension 5% , 7% , 8% and 8% in Ⅰ - Ⅳ groups respectively. Compared with group Ⅰ , the incidences of cough were significantly decreased in Ⅱ - Ⅳ groups, while the incidences of severe sinus bradycardia increased in Ⅲ -Ⅳ groups (P ＜ 0.01) . There was no significant difference in the incidences of cough among Ⅱ - Ⅲ groups and in the degree of cough among the four groups (P ＞ 0.05). Conclusion Intravenous dexmedetomidine 0.10 μg/kg can be used to prevent sufentanil-induced cough during anesthesia induction.

Hereditary renal diseases (inherited kidney diseases) include glomerular diseases,tubular diseases and cystic diseases.The incidence of inherited kidney diseases is relatively low, but the variety of clinical insufficient understanding of the disease, the means test about inherited kidney diseases is also not standardized, easily lead to missed diagnosis and misdiagnosis.As the common clinical manifestation of hereditary renal disease and congenital/hereditary renal disease are mainly low blood potassium, kidney stones, polyuria, growth retardation, and may develop renal failure without treatment.Therefore, clinicians should pay special attention to the diagnosis of congenital/hereditary renal disease, and early interventions are recommended.

Objective:To evaluate the surface free energy and Streptococcus mutans(S.mutans)adhesion on the surfaces of Co-Cr al-loy specimens fabricated by selective laser sintering(SLS)and casting method(SG and W280)respectively.Methods:The specimens of three groups were polished by SiC sandpaper.Surface morphology test,surface contact angle test and surface adhesion test of S.mu-tans were performed.Results:With the same surface roughness value,the surface contact angle of group SLS,W280 and SG was 66.200 ±3.112,74.212 ±3.206 and 67.238 ±2.047(P >0.05),the surface adhesion of S.mutans colone was 8.88 ±2.90,9.25 ± 2.05 and 8.50 ±1.85(P >0.05),respectively.Conclusion:The cobalt chromium alloy fabricated by SLS and casting method have similar surface performance.

In the treatment of 169 cases of the patients sick with intervertebral disc hemiation by integrated application of acupuncture therapy,Chinese massage therapy and herbal fumigation method.the results showed cure in 129 cases.improvement in 33 cases and failure in 7 cases,and the total effective rate was 95.9%.

After classified into ovary mass pattern, cord-like mass pattern and non-mass pattern, 500 cases of the patients sick with infantile torticollis were treated by Tuina manipulations of pressing and rubbing method, pressing and kneading method, plucking and twisting method, extending and rotating method and the pulling method, with the corresponding manual techniques upon different pattern. The treatment ranged from 20 days to 120 days and the total effective rate was 99.4%.

Objective To carry out the performance evaluation to insure security of inner canister during the design phase, which is the important thin component of the portable sterilizater. Methods The software Mechanica, one of the module of Pro/Engineer was implemented to the flexure analysis of the inner canister. Results The stabilization and strength of inner canister satisfied requirements of the design. Conclusion Not only the security of design data can be proved but the cost and cycle of design can be reduced by using the method of expansion simulation analysis at the same time of the design phase of the equipment.

OBJECTIVE To investigate antimicrobial resistance of Acinetobacter baumannii and detect metallo-?-lactamases (MBLs) in clinical isolates from ICU. METHODS Forty-two strains of A. baumannii were isolated from sputum samples between Jul 2005 and Mar 2007 in Affiliated Hospital of North Sichuan Medical College. Bacteria identification and antimicrobial susceptibility test were performed by VITEK-32 system and K-B disk method. Meanwhile,MBLs were detected by Etest. RESULTS Cefoperazone/sulbactam with low resistance accounted for 2.4%. The resistance to imipenem was 66.7%. The resistance to other antibiotics ranged from 69.4% to 100%. Nine MBLs-producing strains were detected by Etest. CONCLUSIONS Metallo-?-lactamases produced by A. baumannii are one of important mechanisms which caused resistance to imipenem. Cefoperazone/sulbactam and polymyxin can be chosen to treat resistant A. baumannii.

AIM: To reveal whether H2O2, a kind of platelet - derived growth factor (PDGF) signaling molecule, involved in the proliferation of phypoxic pulmonary arlmonary artery smooth muscle cells (PASMCs) and expression of transcription factor NF -?B. METHODS: bar confocal scanning microscopy,immunocytochemistry and Western blot analysis were used. RESULTS: PDGF (30 ng/mL) elevated the intracellular H2O2 in normoxic PASMCs, but decreased that of hypoxic PASMCs significantly. When 100?mol/L H2O2 was added, NF - ?B expression were inhib- ited markedly in hypokic PASMCs, while the same concentration H2O2 resulted in increase of NF - ?B expression in control cells. CONCLUSION: H2O2, a mediator molecule of PDGF signal transduction, act as an inhibitor in hy- poxic PASMCs which is qUiet different from that in normoxic PASMCs. It may effect on the expression of transcription factor NF -?B. NF - ?B induce various gene expression that involving in the proliferation of vascular smooth muscle cells. One mechanism by which PDGF - induced hypoxic PASMC proliferation might be through PDGF alleviating H2O2 inhibition.

Adrenomedullin (AM) is a new peptidergic regulator of vascular function. AM serves as a hormone, which has many biological properties, plays an important role in the many pathophysiological processes, especially shock. This review will highlight the structure, biological properties of AM and the relationship between AM and shock.