0.05).Comparison group model and normal control:detected the numbers of endothelial cells:①1 month:control group contrast with test group has no changed;②3 month:group 30Gy/N(P

OBJECTIVE:To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS:Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS:Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION:Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.

Lens opacity attenuates the contrast sensitivity and clarity of eye due to scattering of light,which leads to poor vision in cataract patients.Phacoemulsification with primary intraocular lens is the primary surgical approach.Some complaints of vision discomfort commonly occur although the vision acuity is good.It is,therefore,vital for us to seek an objective evaluation system of visual quality after cataract surgery.Contrast sensitivity test and visual questionnaire offer valuable input for this issue.Contrast sensitivity can estimate vision function more accurately to better measure visual impairment preoperatively and vision outcome after cataract extraction.

Child ; China ; Emergency Medicine ; Humans ; Pediatrics

Alcoholic liver disease (ALD) is one of the most common chronic liver diseases in clinical practice with a complicated pathogenesis.Genetic factors play an important role in the pathogenesis of ALD and might be the potential targets for the treatment of ALD.This article reviews the susceptibility genes associated with ALD in recent years and points out that the exploration of the mechanisms of action of these genes in the development and progression of ALD can provide a theoretical basis for effective evaluation,diagnosis,and prevention and treatment of ALD in clinical practice.

The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.

The catabolic response to severe injury , burn, inflammatory ,acute pancreatitis and operation is characterized by whole-body protein loss, mainly reflecting increased breakdown of muscle proteins. Glucocorticoids and various proinflammatory cytokines are important regulators of muscle proteolysis in stressed patients. In recent years, three types of treatments have been used to reduce or prevent the catabolic response to injury and sepsis: ①nutritional, ②hormonal, and ③pharmacologic. This article review the catabolic response and the corresponding interruption under the stress conditions.

OBJECTIVE:To observe the clinical efficacy and safety of the effect of desloratadine citrate disodium in the decre-mental treatment of chronic urticaria. METHODS:212 patients with chronic urticaria were randomly divided into decremental treat-ment group and control group. Decremental treatment group was treated with Desloratadine citrate disodium capsules 17.6 mg in the first week,orally,qd;8.8 mg in the second week,orally,qd;8.8 mg in the third week,orally,qod;and 8.8 mg in the fourth week,orally,q3d. Control group was treated with Desloratadine citrate disodium capsules 8.8 mg,orally,qd. The treatment course for both groups was 4 weeks. The clinic data was observed,including clinical efficacy,and serum IgE,clinical symptom scores before and after treatment,recurrence rate and incidence of adverse reactions. RESULTS:The differences were not statistical-ly significant in the total effective rate and incidence of adverse reactions between 2 groups(P>0.05). The recurrence rate in decre-mental treatment was significantly lower than control group(P<0.05). When treatment ended and after 4 weeks of drug withdraw-al,serum IgE levels in 2 groups were significantly lower than before,and decremental treatment group was lower than control group(P<0.01);the IgE level in control group was signiciantly higher after 4 weeks of drug withdrawal(P<0.01)than the end of treatment. After treatment,clinical sympton scores in 2 groups were significantly lower than before(P<0.01),however the ditferenc-es was not significant between 2 groups(P>0.05). CONCLUSIONS:Desloratadine citrate disodium have similar clinical efficacies and safety in the decremental treatment and conventional treatment of chronic urticaria. However,decremental treatment of deslo-ratadine citrate disodium is better than conventional treatment in terms of improving the level of IgE.

Objective]To summarize herbal medicine application regulation of Professor Wu Liangcun in gastric cancer treatment. [Methods]Collect 116 gastric cancer patients from Chinese medicine clinic system during January 1,2014 to December 31, 2014 and establish clinical prescription underlying database. Apply descriptive analysis to drug cumulative frequency, drug-induced taste and nature and apply cluster analysis to 42 drugs using more than 10 times. [Results] In the 116 gastric cancer patients,159 kinds of herbs were used ,the cumulative frequency of herbal medicine was 1816.GanCao was the herb with highest usage frequency, and then was FuLing, ShanYao, TaiZishen;According to accumulated frequency, herbs with tonifying function were at the top position(herbs with tonifying qi function were most), and then was the herbs with function of herbs with the function of clearing excessive heat, herbs with function of herbs with the function of relieving dyspepsia, herbs with function of herbs with the function of regulating qi. In terms of herbs' nature and taste, herbs with sweet taste, plain nature were used most. Cluster analysis divided all used herbs into 5 sections, involving prescriptions Sijunzi decoction, Erchen decoction, and couplet medicines DaoYa with GuYa, JiNeijin with MiHoutao, SheShecao with XianHecao and so on. [Conclusions] Professor Wu Liangcun treats gastric cancer with the law of tonifying qi, the main prescription is the same as Sijunzi decoction, emphasizing nourishing Yin and clearing away the heat-evil, protecting gastric, accompanied with promoting digestion and regulating qi.