Blood Circulation ; Carbon Dioxide ; blood ; Humans ; Medicine, Chinese Traditional ; Meridians ; Qi ; Science

To appraise the preventive and improvable effects of different movements on OA joints,animal models by fixing the left posterior knee joint in extention using plaster cast for 8 weeks in Newzealand rabbits were carried out. The rabbits were randomly divided into different groups, and the X-RAY、range of motion and ligament biomechanical features of the joint were observed.The results showed that proper movement improved the range of motion, restored tensile strength of the ligament around the OA joint.It is evident that movement improves the function of the OA joint and delays the OA exacerbation.The combination of active and passive movement is the best way to achieve good result.

Objective To investigate the effects of electro-acupuncture (EA) combined with repetitive transcranial magnetic stimulation (rTMS) on protein kinase A-cyclic adenosine monophosphate response element binding protein (PKA-CREB) signal transduction system after focal cerebral ischemia in adult rats and to explore the mechanism of EA combined with rTMS in treating ischemic brain injury.Methods The animal model of transient focal ischemia was made by artificial middle cerebral artery occlusion. Seventy-five Wistar rats were randomly divided into normal group, model group, EA group, rTMS group and EA+rTMS group. The expressions of PKA and pCREB in hippocampus were detected and the neurologic impairment rating was observed at the 7th, 14th and 28th days, respectively, after infarction.Results The average gray densities of PKA and pCREB expressions in hippocampus after focal cerebral ischemia in model group were higher at the 7th d, lower at the 28th d than that in normal group (P＜0.05);higher in EA group, rTMS group, EA+rTMS group than that in model group at all time points (P＜0.05), higher in EA+rTMS group than that in EA group and rTMS group at 7th and 14th d(P＜0.05), and there was no difference between EA group and rTMS group(P＞0.05).The improvement of neural motor function was obvious in EA group, rTMS group and EA+rTMS group compared with model group (P＜0.01), especially in EA+rTMS group.Conclusions EA combined with rTMS can promote the functional recovery after cerebral ischemia,enhance the expression of PKA-CREB signal transduction system in hippocampus after focal cerebral ischemia, which might be one of the important mechanisms of EA combined with rTMS in treating ischemia brain injury.

Objective To research the methods of treating gynecological inflammatory diseases with TCM. Methods By analyzing gynecological etiology and pathogenesis of inflammatory diseases, we explored the functions of pathogenic dampness, heat, blood stasis, and deficiency of genuine Qi on the onset, development and changes of gynecological inflammatory diseases. Results Gynecological inflammatory diseases is mainly caused by external invasion of pathogenic dampness, heat and insect poison and internal disorder of viscera, leading to the generation of internal dampness, heat, blood stasis and turbid fluid. Besides, the deficiency of genuine Qi is also a major reason for this disease. The therapeutic methods should be eliminating dampness, clearing heat, removing blood stasis, and strengthening genuine Qi. Conclusion TCM is effective in treating gynecological inflammatory diseases.

Objective To investigate the value of contrast enhanced ultrasound (CEUS) in diagnosing poor differentiated cholangiocarcinoma. Methods Sonograms of 11 patients with pathologically confirmed poor differentiated cholangiocarcinoma were retrospectively analyzed. The size, boundary, shape, echo, blood distribution and characteristics of the enhancement duration were observed. Results All lesions presented irregular shape (100%), most (9/11, 81.82%) with indefinite boundary, some (6/11, 54.55%) with low echo. No blood flow signal was found in the interior of masses, while grade 1 blood flow signal was detected in periphery of the lesions. Resistance index (RI) was ≥0.6 in spectral Doppler in 7 (63.64%) lesions. Marginal rim-like hyperechoic enhancement in the arterial phase was found without centripetal filling in all 11 patients, marginal rim-like hypoechoic enhancement was observed, but being hyperecho compared with interior part without medium in delayed phase. Conclusion The contrast-enhancement modality of poor differentiated cholangiocarcinoma is characteristic. Combined with two-dimensional ultrasonography and color Doppler ultrasound, the diagnostic rate will be improved.

Objective To investigate the clinicopathological characteristics and treatment of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Methods Seven patients were confirmed as NLPHL by pathologic immunohistochemistry. Six patients received combined-modality therapy of chemotherapy and involved field, and the other one received single chemotherapy. Results The 3-year local control rate and overall survival rate were 100 % and 86 %, respectively. Only one case died of pulmonary infection following chemotherapy. Conclusion These patients with NLPHL has favorable prognosis, tolerance and less toxicity for combined-modality therapy. However the management of toxicity following treatment should be noted.

Objective:To observe autophagy in human peripheral blood T lymphocyte.Methods:Peripheral blood T lymphocytes of healthy adults were separated with Percoll(1.073 g/ml) and harvested by using nylon column. The cultured cells were divided into control and dexamethasone(DXM) group, and cell morphology was observed through light microscope, electron microscope and fluorescent microscope at 0 and 72 h. And incidence rate of autophagy was analyzed by flow cytometry.Results:①The natural cultured T lymphocytes showed typical morphology of autophagy. ②There was significant statistic difference between 0 and 72 h incidence rate of autophagic T lymphocyte in both control and DXM group. ③There was significant statistic difference in 72 h incidence rate of autophagic T lymphocyte between control and DXM group.Conclusion:Autophagy can be seen in human peripheral blood T lymphocytes, and DXM could induce autophagy.

Systemized ethics is the evitable choice of the history development. The rise of systemized ethics is the important change of emphasis on morality construction. The implement of systemized ethics is not only beneficial to organically integrate universality and advance, but also realize the moral-living theory. The exertion of function of systemized ethics depends on the degree of systemized ethics.

The innovation of social structure propels the advent of systemized ethics,which is a unity of objectivity and rationality.The systemized ethics is the foundation of the morality reconstruction,and the main manifestation of modern ethics.It's not only universal applicable,but acceptable also.

The network teaching reformation is a result of the rapid development of internet technology and the creation of constructivism theory.The Webquest form practice of network teaching depends on the careful analysis of network teaching aim,the reasonable design of network teaching content,and the scientific arrangement of network teaching plate.The application of the Webquest form is a useful attempt.It is helpful to improve the comprehensive qualities of medical students.And it is helpful to re-construct the relationship between the teacher and the student.