OBJECTIVE:This article discusses the key factors of influencing the development of Chinese pharmaceutical industry over a long period of time METHODS:The system analysis and cause-effect analysis were used RESULTS & CONCLUSION:The factors include the relation between production,marketing and consumption,the economic level and structure of demand,the degree of global competition,the market regulation and barrier

OBJECTIVE:To study the competitive condition and development strategy of China's pharmaceutical industry.METHODS:Applying the methods of industry economy theory.RESULTS & CONCLUSION:Features of pharmaceutical industry competition find expression in different products competition,relative monopolistic competition and scale dominant competition.China's pharmaceutical industry is developing rapidly.But its degree of centralization,profit,scale effect and ability of research and development is low,it is still in disperse and low level competitive condition.In the course of establishing new management system,we need setting up effective mechanism of industry policy,carrying out different competitive strategy,supporting good enterprises and pushing formward intensive development of China's pharmaceutical industry.

The pathogenesis of acute pancreatitis(AP)has been a hot issue around the world.Regarding the pathogenesis of AP,there are mainly the trypsin autodigest doctrine,microcirculation theory,inflammation and cell-medium theory,theory of intracellular calcium overload,bacterial translocation and the "two-hit" theory,oxidative stress and doctrine of NO role,and so on.Resveratrol,a natural plant extraction with a wide therapeutic effect of anti-inflammation and anti-oxidation,inhibits platelet aggregation,improves microcirculation and has other pharmacological effects.In recent years,we have carried out extensive and in-depth literature-based studies on the mechanisms for AP and the therapeutic effect of resveratrol on rat AP models,and confirmed that resveratrol could relieve AP-caused damage to the pancreas and the resulting multiple-organ injury.

1.There were 80 heart specimens(age:17～95,with no marked pathological chauges) used to observe the origin,course and the site of anastomosis of the atrial arteries. 2.Within the 80 specimens there are 34 hearts with anastomoses,and the frequen- cies of the anastomoses are 53,including one case of anastomosis between an artery of extracorary origin and the atrial artery. 3.The commonest site of the anastomosis is the posterior wall of the left atrium, there are 23 cases(43.40%)within the 53.The other sites are the base of interatrial septum,13 cases(24.53%);anterior wall of the atrium,13 cases(24.53%);the lateral wall of the right atrium and the orifice the superior vena cava being 2 cases respecti- vely(3.77%). 4.The diameters of the anastomosis are as follows:In the A.B.S.casts:We have measured the anastomotic diameter in 38 cases.Most of them are within the range of 100～200?m in 20 cases(52.6%),200～300?m in 9 cases(23.6%). In dissecting specimens:Within the measured 19 cases,50～100?m in 8 cases (42.1%),100～200?m in 5 cases(26.3%),200～300?m in 3 cases(15.8%),300～ 500?m in 3 cases(15.8%).Among the adult hearts,it seems that the diameter of the anastomosis and the site of the anastomosis are not increased by advancement of the age. 5.The origin of the anastomotic branch of the A-V node artery is near the A-V node.This is very important for the blood supply of A-V node,when there is patholo- gical changes of the coronary artery. 6.Since there is a great range of variation in the diameter of the anastomosis and the formation of the anastomosis,such as two-branches-form,three-branches-form, four-branches-form,or network-like anastomosis,perhaps,the morphological charact- eristics of the anastomosis is closely related with the pathogensis of coronary artery. 7.In this set of specimen,we have observed three cases in which the ventricular branches of the coronary artery joined the anastomosis on the wall of the atrium.

1. 50 heart specimens (30 ABS cast and 20 dissected specimens) were used to study the origin, course and diameter of the branches of the atrial artery. And some measurements were made. 2. Most of the S-A node artery are the first or second anterior atrial branch. In 26 cases (52%), it arises from the right coronary artery, with a diameter of 1.2～ 2.2mm; and in 24 cases (48%)from the left coronary artery, with a diameter of 1.1～ 2.0mm. Their courses are closely related with the anterior interatrial sulcus and the interatrial muscular bundle. Most of the right and left S-A node arteries take a counter-clockwise course and end at the orifice of the superior vena cava. During their course around the orifice of the superior vena cava, a descending loop is present in the posterior interatrial sulcus, only in two cases which is different from McAlpine's observation. Only in 6 cases the origin of the S-A node artery is at the other site, i. e. 4 from left circumflex atrial artery, and 2 from the extension of the terminal branch of the right coronary artery. 3. Kugel's artery usually arises from these branches of the promixal part of the right or left coronary artery, i. e. from the left or right S-A node artery, or from the left or right anterior atrial artery. It usually penetrates into the septum at the anterior interatrial sulcus, with a diameter of 0.1～1.2mm, during penetration. In the septum it has a constant course around the inferior border of the fossa ovalis and may be anastomosed with the branches of the right and left coronary artery at the posterior wall of the atrium. This is an important collteral circulation of the coronary artery. 4. A-V node artery usually arises from the right coronary artery, 94%; and only a small portion, 6%, from the left coronary artery. Its diameter is around 0.4～1.9 mm. Usually only one A-V node artery is present. Double A-V node artery is observedonly in 2 cases both of them are arising from the right coronary artery. In 2 cases, A-V node artery arises from the posterior ventricular branches, penetrates into the posterior wall of the left ventricule, runs between the right and left atrioventricular foramin and reaches the A-V node. In 44.23% of the 50 specimens, A-V node artery take its origin from the top of the "U" turn of the coronary artery at the crux. In 36.5% of the specimen the artery originates from the plain straight type of coronary artery; in the other 19.24% though the "U-turn" is present, but the artery does not originate from the top of the turn. The course of the artery is generally along the midline between the right and left atrio-ventricular foramina, and rarely along the borders of the left or right afrioventricular foramina. 5. The clinical importances of the topographical characteristics are discussed.

?-adrenoceptor,whose subtypes ?1-and ?2-adrenoceptor are expressed on panreatic cancer cells,is closely related to the occurrence and development of pancreatic cancer.?-adrenoceptor agonists epirenamine,isopropylarterenol and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK) induce pancreatic cancer proliferation.Research on the molecular mechanism is as follows: Activating ?-receptor can stimulate protein kinase A(PKA)/arachidonic acid(AA) pathway in pancreatic cancer cells.NNK also stimulates mutation of Ras and the activation of Src tyrosine kinase and Ras,followed by activation of mitogen activated protein kinase(MAPK) pathway.?-adrenoceptor can make the epidermal growth factor(EGFR) pathway transactivated,and the EGFR and ?-adrenergic signalling pathways might synergize to activate Src and Ras.Increased evidence suggests that patients with pancreatic adenocarcinoma share many risk factors,such as smoking and chronic depression,with cardiovascular disease patients.Drugs to block ?-adrenoceptor in cardiovascular diseases might be used for the prevention and treatment of pancreatic cancer.

Objective To explore the protective effect of resveratrol on rat brain injury resulting from severe acute pancreatitis (SAP). Methods Ninety-six male Sprague-Dawley rats were randomly divided into four groups:sham-operation (SO) group,severe acute pancreatitis (SAP) group,resveratrol-treated (RES) group and dexamethasone-treated (DEX) group,with eight rats in each group evaluated at 3,6 and 12 h. Levels of serum myelin basic protein (MBP),tight junction protein zonula occludens 1 (Zo-1),TNF-? and IL-6 were determined by ELISA. The ultrastructural changes of the brain and pancreatic tissues were examined using a transmission electron microscope. Results MBP,Zo-1,TNF-? and IL-6 levels in RES group were lower than those in SAP group at all time points (P0.05). Conclusion The degradation of Zo-1 is involved in the pathophysiology of brain injury in SAP; MBP can be used as a marker of brain injury in SAP rats. Resveratrol can inhibit brain injury associated with SAP.

Objective To establish a stable brain injury model with pancreatitis and explore the mechanism of brain injury resulting from severe acute pancreatitis (SAP) in experimental rat models. Methods Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham operation (SO) group, SAP group and trypsin group, with eight rats in each. Brain tissue and pancreas tissue specimens were collected at 12 h after treatment. Death rate in each group was evaluated; the level of tight junction protein zonula occludens 1 (Zo-1) was determined by enzyme-linked immunosorbent assay. The ultrastructure of the brain tissues was examined using transmission electronic microscope; pathological changes in the brain tissues were observed with HE staining. Results The death rate was increased significantly in SAP group compared with that in trypsin group; no rats in SO group died. Zo-1 level was obviously lower in SO group than in SAP group and trypsin group (P<0.05). The ultrastructural changes were seen in the latter two groups, including obvious neuronal cell swelling, capiliary stasis, increased vascular permeability, thrombosis and cell apoptosis. Conclusion Trypsin may cause brain injury with pancratitis. The death rate of SAP model established by trypsin was low. We have provided a stable animal brain injury model for further study and treatment of brain injury.

Recent studies indicated that epigenetic abnormality is the important molecular mechanism in leukemia. The change of epigenetic modification occurs in most kinds of leukaemia. Based on the epigenetic modification, the therapies of leukemia with hypomethylating agents and histone deaeetylases inhibitors, which are different from traditional chemotherapy are applied in the treatment of leukemia at beginning. The aim of this article is to summarize the recent advances of DNA methylation and histone modification in leukaemia occurrence, treatment and prognosis.

Objective To reconstruct the three-dimensional(3D) image and to study on the virtual anatomy of the thigh part based on computed tomography(CT) data source. Methods Ten patients' contrast-enhanced light-speed CT images of the thigh part were chosen, “3D medical studio” was applied to read CT data, then to reconstruct and anatomize the thigh part. Results The reconstructed 3D images of the thigh part were realistically pseudocolored displayed, it was composed of four kinds of tissues(skin, muscle, skeleton and artery) and could be freely rotated and incised and restored for many times at any shape and depth on real time. Its' layers were distinct among tissues. Conclusion This research realizd partial function of virtual anatomy, it may play a definite role on regional anatomy and sectional image anatomy teaching and clinical radiology diagnosis.