ADP receptors on platelets are mainly divided into two categories: P2X and P2Y. The activation of P2Y receptor is closely related to the occurrence and development of cardiovascular diseases. It plays an important role in regulating platelet activation and aggregation, vascular inflammation, thrombosis and so on. It is the target of ADP receptor blockers. This kind of drugs is also a hot spot in the research and development of antiplatelet drugs. This article reviews the role of P2Y receptor in the occurrence and development of cardiovascular diseases, in order to provide new ideas and reference for the application of P2Y receptor antagonists in the treatment of cardiovascular diseases.