Objective To observe the performance of two-dimensional echocardiography and CDFI of metastatic cervical lymph nodes in nasopharyngeal carcinoma before and after induction chemotherapy,and to predict the short-term effect of the lymph nodes after sequential chemoradiotherapy.Methods Forty patients with sixty-five metastatic cervical lymph nodes which were confirmed as nasopharyngeal carcinoma by biopsy and CT were studied.CDFI was used to observe its size,the peak systolic velocity (PSV),resistivity index (RI),and record its classification of blood flow before and after induction chemotherapy,after radiotherapy 1 to 2 months for ultrasound,respectively,and the measured values and short-term effect in cervical lymph node metastasized were compared.Results According to the changes of blood supply after induction chemotherapy,lymph nodes were divided into three groups,the group of improve blood supply was given priority (55 ％),blood supply to reduce and no change groups were 23 ％,22％,respectively.After induction chemotherapy and sequential radiotherapy,all lymph nodes were narrow,regression rate after induction chemotherapy in blood supply to reduce,improve and no change groups were 52％,36％,25％,respectively,the regression rates of sequential chemoradiotherapy were 90％,81％,70％,respectively,among three groups are in degressive tendency,differences were significant (P ＜ 0.05).The blood supply changes after induction chemotherapy related well with the regression rate of chemotherapy(r =0.572,P =0.000) and sequential radiotherapy(r =0.553,P =0.000).The regression rate of chemotherapy related well with the regression rate of sequential chemoradiotherapy(r =0.621,P =0.000).After chemotherapy three groups of lymph node RI decreased,the difference was significant compared with that before treatment (P ＜ 0.05).After chemotherapy the groups to reduce and improve of PSV had significant differences compare with that before treatment (P ＜ 0.05),the group of blood supply no change of PSV had no significant difference (P ＞ 0.05).Conclusion Application of CDFI can clearly and accurately observe changes of metastatic cervical lymph nodes from nasopharyngeal carcinoma before and after induction chemotherapy,and the changes of blood supply and size after induction chemotherapy can predict the short-term effect after chemoradiotherapy.

OBJECTIVE: To compare the results of skin prick test with allergens of Allergopharma company or ALK company in Shanghai area. METHOD: The study included 9 233 patients diagnosed as allergic rhinitis. The patients were divided in to two groups (Allergopharma group and Alutard-SQ group) SPT was given from June, 2005 to Feb, 2013. The results of the positive rate using two reagents were analyzed and compared. RESULT: There were no significant differences between the two groups in age and gender (P > 0.05). The total positive rate in Allergopharma group was 62.90%, and 59.68% in Alutard-SQ group. The positive rate in Allergopharma group was significantly higher than that in Alutard-SQ group (P < 0.01). Dermatophagoides farinae (Der f) and Dermatophagoides pteronyssinus (Der p) were identified as the mostly responsible allergens. The positive rate of Der f in Allergopharma group and Alutard-SQ group was 55.23% and 45.57% respectively. The same rate were 54.83% and 47.89% of Der p. There were significant differences of the positive rate of two allergens in both groups (P < 0.01). CONCLUSION The total positive rate was different using different allergens for SPT among the patients diagnosed as allergic rhinitis of the same area. Dust mites were identified as main allergens. The positive rate was different when using different reagents, which needed more attention to make the decision of specific immune therapy.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Allergens ; immunology ; Antigens, Dermatophagoides ; immunology ; Child ; Child, Preschool ; China ; Female ; Humans ; Indicators and Reagents ; Male ; Middle Aged ; Rhinitis, Allergic ; diagnosis ; Skin Tests ; Young Adult

Objective To evaluate the cost-effectiveness of the comprehensive control measures carrying out in schistosomia-sis endemic inner embankment of marshland and lake regions from 2006 to 2010,so as to provide the reference for further rational allocation of limited health resources and ultimately speeding up the procedure of schistosomiasis elimination. Methods With ref-erence to the requirements of the national schistosomiasis transmission control and phase goals for schistosomiasis control in Hubei Province,Jiangling County,one schistosomiasis control pilot of Hubei Province combined with the National Health and Family Planning Commission and Ministry of Agriculture,was selected for the study. A definition of the infection rates of human and do- mestic animals was used for endemic villages stratified by different layers(i.e.,the village with the infection rates of human and domestic animals ≥3% belonged to the first layer,≥ 1% belonged to the second layer;<1% belonged to the third layer). By us- ing the stratification method and cost-effectiveness analysis,the endemic villages stratified with the different layers were investi- gated and all the data of schistosomiasis endemic situation,cost and effectiveness of schistosomiasis control were collected and comprehensively analyzed from 2006 to 2010. Results In the effectiveness of schistosomiasis control,by the end of 2010, there were no first layer villages,there were 114 second layer villages,and there were 18 third layer villages in Jiangling Coun- ty. In the former first layer villages,the schistosomiasis patients decreased year by year ultimately to 0;but in the second and third layer villages,the schistosomiasis patients increased. In the fecal treatment and management,the coverage rates of harm- less sanitary latrines were 27.45% in 2009 and 48.74% in 2010 respectively in the second layer villages,whereas there were no harmless sanitary latrines in the first and third layer villages. In the 5 years,the input of comprehensive control measures was 10 266 3900 Yuan,much higher than the human and buffalo examinations and treatments,Oncomelania hupensis snail investi- gation and elimination(4 183 000 Yuan)and other labor inputs(2 239 500Yuan). In the ratio of cost-effectiveness,the annual ratio of unit cost(1% reduction of human and buffalo infection and 1 hm2 reduction of snail areas)increased yearly. In addition, the semi-logarithmic stability trend analysis of health inputs and cost showed that there was a stable balance between inputs and cost in the different layers(logarithmic values of any two layers of pair-wise comparison were <1,and in the third layer villages, the annual average logarithmic values of 5 years were <1). Whereas,in the first and second layer villages,the annual average cost was fluctuated(the costs was higher than the inputs). Conclusion The schistosomiasis situation is reduced year by year in Jiangling County from 2006 to 2010. Whereas,the main infection source(buffaloes)still exists and the present control mea- sures including fecal management should be further strengthened. In the resource allocation,in the field of health,the annual distribution of key inputs and unit-cost control also has a further space of adjustment.

Cerebrospinal Fluid Leak ; surgery ; Endoscopy ; Humans ; Iatrogenic Disease ; Male ; Meningocele ; surgery ; Middle Aged ; Nose ; surgery

OBJECTIVE: The role of different local flaps in small external nasal skin defect reconstruction was discussed. METHOD: Forty-two cases of the small size nasal defects (diameter < 2 cm) were repaired with local external nose flap (includes the dorsal nasal flap, nasolabial flap and bilobed flap). The clinical and follow-up data were analyzed of patients with small external nasal skin defects, who accepted different local flaps reconstruction. Dorsal nasal flap, nasolabial flaps (includes island flap, slid flap and axial flap) and bilobed flap were tailored to reconstruct different external nasal defect. Twenty-seven patients were male and fifteen patients were female, the patients' age ranged from 28 to 74 years, the median age was 61 years. Thirty-eight cases resulted from resection of skin malignant tumor and four cases were benign lesions. The diameter of defects was 1-2 cm. The defects were reconstructed by single-stage dorsal nasal flap in 7 cases. There were 30 cases of caudolateral nasal defects were reconstructed by nasolabial flap, single-stage island nasolabial flap in 7 cases, axial flap in 18 cases and slid flap in 5 cases. Superior lateral defects were reconstructed by single-stage bilobed flap in 5 cases. RESULT: All defects were repaired successfully. All tissue flaps survived and had not necrosis. There was no tumor recurrence during 3 months to 2 years follow-up. CONCLUSION The dorsal nasal flap, nasolabial flap and bilobed flap can be used safely and effectively to repair the small external nasal defect and have satisfactory curative effect.
Adult ; Aged ; Dermatologic Surgical Procedures ; methods ; Face ; pathology ; surgery ; Female ; Humans ; Male ; Middle Aged ; Nose ; pathology ; surgery ; Reconstructive Surgical Procedures ; methods ; Skin ; pathology ; Surgical Flaps

Objective To evaluate the effect and safety of nicorandil on Coronary Slow Flow Phenomenon (CSFP) .Methods The CSFP patients(n=60) were randomly divided into the control group treated with placebo and the treatment group treated with nicorandil .The changes of the clinical symptoms ,the frequency and duration of pectoralgia ,the six-minute walk test ,and TIMI frame counts were observed before and after treatment .Results The treatment group had a better therapeutic effect than the con-trol group(P<0 .05) .There were significant differences in the frequency and duration of pectoralgia ,the six-minute walk test ,and TIMI frame counts in treatment group before and after treatment ,which were superior to those of control group (P<0 .05 ,P<0 .01) .The blood routine examinations and hepatorenal function were within the normal range before and after treatment .Conclusion Nicorandil has better therapeutic effect and safety on CSFP .

Objective To analyze the spatial-time distribution characteristics of schistosomiasis in Jiangling County ,Hubei Province from 2006 to 2011. Methods The surveillance data of schistosomiasis of Jiangling County from 2006 to 2011 were col-lected,and a spatial database was established. The spatial-time permutation cluster analysis was performed by SaTScan 9.1.1 to detect the spatial-time cluster areas of schistosomiasis,and a risk map was drawn by ArcGIS 10.0. Results Compared to 2006, the infection rates of human,cattle and Oncomelania hupensis snails decreased by 47.67%,93.34%and 52.41%,respectively in 2011. The space-time permutation clustering analysis of the infection rates of human,cattle and snails showed 4,3 and 4 clusters,respectively,and all the clustered areas were distributed in inner embankment areas. Conclusions From 2006 to 2011,the schistosomiasis endemic situation presents a decline trend in Jiangling County. The detected cluster areas are the im-portant areas for schistosomiasis control. The space-time permutation statistics could be used in the analysis of endemic situation of schistosomiasis.

Objective To investigate the preliminary experience of mechanical thrombectomy with a tri-axial system of the Solitaire AB stent through a Neuro delivery catheter to treat intracranial large artery occlusion. Methods A tri-axial system was used to deliver the Solitaire AB stent through a Neuro delivery catheter to provide intracranial aspiration in close proximity to the stent. This technique was used in 1 case of acute middle cerebral artery occlusion and 1 case of acute basilar artery occlusion. Results Successful revascularization was achieved in these 2 cases. Thrombolysis in cerebral infarction (TICI)score was 3. The clot length of acute middle cerebral artery occlusion was 3 cm and the modified Rankin Scale (mRS)score of this case was 3 at 90 days follow-up. Another patient with acute bilateral vertebral occlusion was revealed successful recanalization by angiography. Conclusion The results suggest that this technique of a tri-axial system used of the Solitaire stent through a Neuro delivery catheter can effectively retrieve clots from the occlusive artery and minimize the chance of antegrade blood flow dislodging the thrombus.

Objective: To analyze the effect of a new type of metal clip hemostat in bleeding under endoscopic colonic polypectomy. Methods: From January 2016 to December 2017, 298 cases of colonic polypectomy hemorrhage patients in the Third People's Hospital of Hangzhou were studied, and they were randomly divided into study group (149 cases) and control group (149 cases) according to the digital table.The control group was given general hemostat and hemostatics, and the study group was given new metal clips and hemostatic drugs under endoscopy.The hemostasis rate, the prognosis in the near and long term and the score of the severity of clinical symptoms at different treatment time points (T₀-before treatment, T₁-12h after treatment, T₂-24h after treatment and T₃-48h after treatment) were compared and analyzed in the two groups. Results: The immediate hemostasis rate (86.58%), effective hemostasis rate (73.15%) and complete hemostasis rate (66.44%) in the control group were significantly lower than those in the study group (100.00%, 93.29% and 89.93%), and there were statistically significant differences in bleeding rates between the two groups (χ²=21.439, 21.629, 24.104, all P<0.05). The fecal occult blood clearance time [(3.54±0.18)d], bowel sound recovery time [(5.21±0.45)d] and hospitalization time [(8.42±0.75)d] of the study group were significantly shorter than those of the control group [(4.16±0.27)d, (7.18±0.26)d and (9.65±1.27)d], the differences were statistically significant between the two groups(t=23.322, 46.270, 10.180, all P<0.05). The rebleeding rate[(6.71%)(10/149)], complication rate[(3.36%)(5/149)] and mortality[(0.00%)(0/149)] in the study group were all lower than those in the control group [26.85%(40/149), 8.05%(12/149), 6.71%(10/149), 2.01%(4/149)], the differences were statistically significant between the two groups (χ²=21.629, 3.057, 1.755, 3.031, all P<0.05). The difference of clinical symptom severity score of the two groups at T₀ was not obvious (P>0.05). The scores of clinical symptoms of the two groups at T₁, T₂ and T₃ were decreased in turn, and the scores in the study group were all lower than those in the control group(t=77.562, 54.816, all P<0.05). Conclusion After bleeding in patients with colonic polyp electrotomy, the hemostatic rate of the new metal clip after endoscopic hemostasis is significantly improved, the curative effect is stable, the recurrence rate of bleeding is low, and the clinical application value is high.

Objective: To explore the impact of five-flavor Sophora flavescens enteric-coated capsules (FSEC) on the intestinal flora of rats with ulcerative colitis (UC), so as to provide the reference for the mechanism of FSEC in treating UC. Methods: Forty SPF-grade Wistar rats were randomly divided into the control group, the model group, the mesalazine group and the FSEC group. Except the control group (0.9% sodium chloride solution), the other 3 groups used 3% dextran sulfate sodium (DSS) for 7 days to establish UC model. After successful modeling, the control group and the model group were given 2 mL/kgbw of 0.9% sodium chloride solution by gavage for 2 weeks, while the mesalazine group and the FSEC group were given 2 mL/kgbw of mesalazine suspension (0.2 g/kg) and FSEC granule suspension (2.16 g/kg), respectively. Pathological changes of colon tissue were observed after hematoxylin-eosin (HE) staining. Rat fecal samples were collected, and 16S rDNA high-throughput sequencing and bioinformatics analysis were performed on intestinal flora. The α and β diversity of intestinal flora among the four groups were compared, and the dominant flora was screened using LEfSe analysis. Results: Compared with the control group, the model group showed a significant loss of colonic crypts and a large infiltration of inflammatory cells. Compared with the model group, the mesalazine group and the FSEC group exhibited a slight loss of colonic crypts, a small amount or an absence inflammatory cell infiltration, and improved tissue damage. The α-diversity analysis showed that compared with the control group, the Chao1 and Shannon indices in the model group increased, while the Simpson index decreased; compared with the model group, the Chao1 and Shannon indices in the mesalazine group and the FSEC group decreased, and the Simpson index increased（all P<0.05）. The β-diversity analysis showed that the sample distance between the FSEC group and the control group were more closer than that between the model group and the control group. LEfSe analysis results showed that the dominant bacteria in the model group were mainly from the Alistipes and Oscillospira. In the FSEC group, the dominant bacteria were from the Ruminococcus and Prevotella. Conclusion FSEC can improve the structures of intestinal flora, increase the abundance of beneficial bacteria such as Ruminococcus and Prevotella, reduce the abundance of pathogenic bacteria such as Alistipes, and alleviate the inflammatory response in UC rats.