Background:Gastroesophageal reflux disease(GERD)is a common disease,its incidence is related to geographic environment and race. Studies reported on epidemiology of GERD in minority groups are rare. Aims:To investigate the prevalence and related risk factors of GERD in She population in Ningde. Methods:Three natural villages of She population in Ningde were selected for undergoing the cluster random sampling method. GERD was diagnosed by gastroesophageal reflux disease questionnaire(GerdQ)with score ≥8,and questionnaire was used to detect the prevalence and risk factors of GERD. Results:A total of 936 residents completed the questionnaire,and 89 were diagnosed as GERD, the prevalence was 9. 50% . Univariate analysis showed that the risk of GERD was significantly increased in She population with body mass index(BMI)≥24 kg/ m2 ,intake of strong tea or oily diet(P all < 0. 01). Multivariate analysis showed that BMI ≥24 kg/ m2(OR = 3. 022,95% CI:1. 917-4. 765),intake of strong tea(OR = 2. 145,95% CI:1. 338-3. 438) and oily diet(OR = 2. 016,95% CI:1. 208-3. 318)were the risk factors of GERD. Conclusions:The prevalence of GERD is high in She population in Fujian Province,and the etiology may be related to overweight and diet habit.

Aim To investigate the protective effect of non-mitogenic human acidic fibroblast growth factor (nm-haFGF) on cerebral ischemia-reperfusion injury in mice. Methods Cerebral ischemia-reperfusion model was made by ligating bilateral carotid for 20 minutes in mice. These mice were randomly divided into model group( iv NS), two doses of nm-haFGF (iv 25、50 ?g?kg-1) groups, rhaFGF group(iv 50 ?g?kg-1) and sham- operated group. Step down test and Y-type electric maze were used to examine the effect of nm-haFGF on learning and memory of mice, then Even′s Blue(EB) level and NO level in brain of these mice were measured. Results The nm-haFGF significantly decreased numbers of errors of mice in 5 min in step down test and in Y-type electric maze test; EB and NO levels in brain of these mice were lower than those of model group respectively. Conclusion The nm-haFGF can protect cerebral ischemia-reperfusion injury in mice.

Objective To explore the effects of low tube voltage and contrast dose on the prospective ECG gating coronary artery imaging in overweight patients.Methods A total of 80 overweight patients were randomly divided into control group (traditional tube voltage and contrast medium dose) and observation group (low tube voltage and contrast medium dose),and effect of prospective ECG gating coronary artery imaging was compared.Results In the observation group,the excellent rate of imaging quality was 90％,and which in the control group was 92.5％ (P ＞ 0.05).There were significant differences in values of CT coronary artery imaging,image noise,image signal-tonoise ratio and radiation dose between two groups (P ＜ 0.05).Conclusion Low tube voltage and contrast dose can significantly reduce the patient's radiation dose.

Objective To explore the effects of low tube voltage and contrast dose on the prospective ECG gating coronary artery imaging in overweight patients.Methods A total of 80 overweight patients were randomly divided into control group (traditional tube voltage and contrast medium dose) and observation group (low tube voltage and contrast medium dose),and effect of prospective ECG gating coronary artery imaging was compared.Results In the observation group,the excellent rate of imaging quality was 90％,and which in the control group was 92.5％ (P ＞ 0.05).There were significant differences in values of CT coronary artery imaging,image noise,image signal-tonoise ratio and radiation dose between two groups (P ＜ 0.05).Conclusion Low tube voltage and contrast dose can significantly reduce the patient's radiation dose.

The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological functions. Therefore, the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases. Here, we identified a novel TEAD1/3 covalent inhibitor (DC-TEADin1072) with biochemical IC