Objective:To explore the effect of perioperative catheterization management strategy on postoperative restlessness during recovery and prognosis in patients undergoing thoracoscopic lobectomy.Methods:From April 2019 to April 2021, convenience sampling was used to select 102 patients with thoracoscopic lobectomy who were admitted to the Thoracic Department of the Second People's Hospital of Lianyungang as the research object. The patients were divided into the observation group and the control group by random number table method, 51 cases in each group. The control group was given routine nursing, and the observation group received perioperative catheterization management strategy on this basis. The incidence of postoperative complications and postoperative comfort scores were compared between the two groups.Results:The incidences of postoperative restlessness, urinary retention and urinary tract infection in the observation group were lower than those in the control group, and the differences were statistically significant ( P<0.05) . The General Comfort Questionnaire score after removal of the catheter in the observation group was higher than that in the control group, and the difference was statistically significant ( P<0.05) . Conclusions:Perioperative catheterization management strategy is beneficial to reduce the risk of restlessness during recovery in patients undergoing thoracoscopic lobectomy, decrease the incidence of urinary retention and urinary tract infection, and improve the comfort of patients after catheter removal.