1.The mediating effects of self-control and rumination between neuroticism and insomnia in college students
Jia YU ; Kezhi LIU ; Xiaojiao ZHENG ; Lidan CAI ; Hui WU ; Huaihong A ; Bin ZHANG ; Shuai LIU
Chinese Journal of Behavioral Medicine and Brain Science 2020;29(8):682-686
Objective:To explore the mediating effects of self-control and rumination between neuroticism and insomnia in college students.Methods:A cross-sectional survey was conducted among 767 college students from a university in Sichuan province with Chinese big five personality inventory-15, insomnia severity index, ruminative responses scale, and self-control scale.Results:The prevalence of insomnia was 36.6% among college students.The scores of neuroticism (9.63±3.41), rumination (22.27±5.44) and ISI (6.61±4.28) were positively correlated with each other ( r=0.281-0.389, P<0.01), while each of them was negatively correlated ( r=-0.453--0.194, all P<0.01) with self-control (60.71±9.41). Analysis of mediating effects revealed that neuroticism not only directly affected insomnia, but also indirectly affected insomnia through the mediating effects of rumination and self-control respectively. Conclusion:Self-control and rumination have mediating effects between neuroticism and insomnia in college students.
2.Erratum: Author correction to 'Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy' Acta Pharm Sin B 13 (2023) 1303-1317.
Xueqin HUANG ; Bingbing SHENG ; Hemi TIAN ; Qiuxia CHEN ; Yingqi YANG ; Brian BUI ; Jiang PI ; Huaihong CAI ; Shanze CHEN ; Jianglin ZHANG ; Wei CHEN ; Haibo ZHOU ; Pinghua SUN
Acta Pharmaceutica Sinica B 2023;13(10):4338-4340
[This corrects the article DOI: 10.1016/j.apsb.2022.08.024.].
3.Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy.
Xueqin HUANG ; Bingbing SHENG ; Hemi TIAN ; Qiuxia CHEN ; Yingqi YANG ; Brian BUI ; Jiang PI ; Huaihong CAI ; Shanze CHEN ; Jianglin ZHANG ; Wei CHEN ; Haibo ZHOU ; Pinghua SUN
Acta Pharmaceutica Sinica B 2023;13(3):1303-1317
In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy. In this study, a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). The Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) to form SERS probes (GO-Fe3O4@Au@Ag-MPBA). Furthermore, doxorubicin (DOX) is attached to SERS probes through a pH-responsive linker boronic ester (GO-Fe3O4@Au@Ag-MPBA-DOX), accompanying the 4-MPBA signal change in SERS. After the entry into tumor, the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal. Thus, the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra. Additionally, the strong T2 magnetic resonance (MR) signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy (PTT). Altogether, this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting, pH-sensitive drug release, SERS-traceable detection and MR imaging, endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment.