Objective:To investigate the prognostic value of preoperative peripheral blood albumin-to-globulin ratio (AGR) for patients with non-metastatic clear cell renal cell carcinoma (NMCCRCC).Methods:The clinicopathological and postoperative follow-up data of 61 patients with NMCCRCC confirmed by postoperative pathology who were admitted to Zhongshan Hospital of Dalian University from January 2012 to December 2014 was retrospectively analyzed. According to the receiver operating characteristic curve (ROC), the optimal cut-off value of AGR was determined. According to the cut-off value, the patients were divided into high AGR group (AGR≥1.59) and low AGR group (AGR<1.59). The factors affecting the prognosis of NMCCRCC patients were analyzed by using univariate and multivariate analyses.Results:Among 61 patients with NMCCRCC, 38 cases (62.3%) were in high AGR group and 23 cases (37.7%) were in low AGR group. The differences in age, globulin level, clinical staging, and recurrence status between the two groups were statistically significant (all P < 0.05). The overall survival time and disease-free survival time in low AGR group were shorter than those in high AGR group, and the differences were statistically significant (both P < 0.05). Multivariate Cox regression analysis showed that AGR < 1.59 was the independent influencing factor for overall survival and recurrence ( HR = 0.233, 95% CI 0.073-0.742, P = 0.014; HR = 0.343, 95% CI 0.134-0.873, P = 0.025). Conclusion:Preoperative AGR is valuable in predicting the prognosis of NMCCRCC patients.