To promote the reasonable development of reference materials in the field of health care in China, on the basis of introducing reference materials and certified reference materials, we summarize the current management system and management norms of reference materials in our country, summarize the development status and trends of reference materials in the field of health care at home and abroad, analyze and discuss the development status, development trend and current challenges of standard materials in the fields of environmental health, medical sanitation and virus detection in China, and look forward to the major demand for reference materials in the field of health in China.