Objective To observe and investigate the effect of esomeprazol in the elderly patients with gastric ulcers and influence for the pepsinogen,cAMP and cGMP.Methods 86 elderly patients with gastric ulcers in our hospital from June 2015 to August 2016 were selected as the research object,and they were randomly divided into control group 43 cases and observation group 43 cases, the control group were treated with omeprazole,the observation group were treated with esomeprazol,the total effective rates,symptom score and pepsinogen, cAMP, cGMP levels before and after the treatment of two groups were compared.Results The total effective rates of observation group at different time after the treatment were higher than those of control group,the symptom scores after the treatment were all lower than those of control group ,the serum pepsinogen were all lower than those of control group,the plasma cAMP and cAMP /cGMP were lower than those of control group,the plasma cGMP were higher than those of control group, (P<0.05), the differences were all significant.Conclusion The clinical effect of esomeprazol in the elderly patients with gastric ulcers is better,and it can significantly improve the expression situation of pepsinogen, cAMP and cGMP of patients, so its application value in the elderly patients with gastric ulcers is higher.