Process analysis technology(PAT)is of great significance to improve the process control and quality as-surance in the manufacture of dermal drug delivery products.This paper reviewed the application of PAT technology in the advanced manufacturing of dermal drug delivery products,introduced the basic situation of PAT and chemo-metrics,and summarized the commonly used PAT tools and their application examples in recent years.In the fu-ture,PAT will play a greater role in the process ofdermal drug delivery products,but the research in this area is still very scarce now.