The use ofYang transforming Qi, Yin constituting the bodycan be used in the treatment of metastasis of breast cancer from pathogenesis transformation view. Based on literature, this article analyzed the theory of Yang transforming Qi, Yin constituting the body and its possible guidance to clinical practice. Then the article illustrated the application cases of this theory in the treatment of breast cancer metastasis.

Celecoxib ; Cell Proliferation ; drug effects ; Drug Resistance, Multiple ; Humans ; Interferon-alpha ; pharmacology ; K562 Cells ; Pyrazoles ; pharmacology ; Sulfonamides ; pharmacology

Cardiac Pacing, Artificial ; Electrodes, Implanted ; Female ; Humans ; Middle Aged ; Postoperative Complications ; etiology ; Subclavian Artery ; injuries ; Treatment Outcome

Adult ; Catheter Ablation ; methods ; Humans ; Male ; Sinus of Valsalva

Adolescent ; Defibrillators, Implantable ; Female ; Humans ; Long QT Syndrome ; therapy

Breast cancer is called "Ruyan" in literature of traditional Chinese medicine. We synthesized the ancient and contemporary discussions and raised the theory that "Duxie" (poisonous pathogenic factor) is the etiological factor and pathologic product through the whole course of breast cancer. "Liuyin Fudu" (latent poison of six exogenous pathogenic factors) and "Qiqing Yudu" (stagnant poison of seven emotions) are the main etiological factors affecting the breast cancer occurrence. "Aidu Neisheng" (internal product of cancer poison) is the essential change in breast cancer occurrence. "Tandu Yujie" (stagnation of phlegm, poison and blood stasis) is the essential pathogenesis of the breast cancer's development. "Yudu Weiqing" (vestigial poison) is the main pathogenesis of breast cancer after operation. "Yudu Pangcuan" (vestigial poison invasion elsewhere) is the key pathogenesis of recurrence and metastasis after operation. "Sanjie Jiedu" (dispersing accumulation and detoxification) is an important therapeutic principle in breast cancer's treatment after operation. The "Tandu Yujie" pathogenesis theory and "Sanjie Jiedu" therapeutic principle developed the theory about breast cancer in traditional Chinese medicine, and have some clinical application value.

OBJECTIVE: To observe the effect of Ruyiping, a traditional Chinese compound herbal medicine composed of 5 Chinese herbs for removing toxic materials and dissipating nodules from Runing II, another traditional Chinese compound herbal medicine for treating breast cancer, in preventing recidivation and metastasis in breast cancer patients after operation. METHODS: Eighty patients with breast cancer after operation were randomly divided into Ruyiping group and Runing II group, and prescribed Ruyiping and Runing II on the basis of chemotherapy, radiotherapy and endocrine therapy respectively for two years. RESULTS: There were two patients with metastasis and three patients lost to follow-up in Ruyiping group and three and two in Runing II group. The recidivation and metastasis rates were 5.41% and 7.89% respectively. The difference between the two groups was not statistically significant (P>0.05). The difference of disease-free survival time between the two groups was also not statistically significant. CONCLUSIONS: The effect of Ruyiping in preventing recidivation and metastasis is similar to that of Runing II. Ruyiping is the essential component of Runing II for preventing recidivation and metastasis. The result provides some clinical evidences for the theory that "Yudu Pangcuan" (vestigial poison invasion elsewhere) is the essential pathogenesis of breast cancer's recidivation and metastasis and the utilization of "Sanjie Jiedu" (dispersing accumulation and detoxification) is the therapeutic principle in preventing recidivation and metastasis after operation.

BACKGROUND: Flatfoot is a commonly seen disease in foot and ankle surgery, and stage II adult acquired flatfoot is mostly seen in clinic, so this stage is a key to treatment. However, medial column instability occurs in stage II adult acquired flatfoot, which is an important cause for arch collapse. Medial column stabilization can correct the deformity to great extent, but there is a lack of biomechanical study to assess the effect of medial column stabilization on the whole foot. OBJECTIVE: To investigate the biomechanical effects of medial column stabilization on stage II adult acquired flatfoot. METHODS: A three-dimensional finite element model of stage IIa and IIb adult acquired flatfoot was established. Geomagic software, Solidwork software and Abaqus software were used to simulate medial column stabilization operation (naviculocuniform joint fusion, tarsometatarsal joint fusion, and both fusion). The maximum pressure of plantar soft tissue, medial column bone and medial ligaments was compared before and after simulated single-foot weight loading. Meanwhile, the related parameters were measured to carry out a comprehensive comparison. RESULTS AND CONCLUSION: (1) The maximum plantar stress was located under the first metatarsal head after the simulated medial column stabilization operation. The maximum plantar stress increased significantly after the medial column stabilization in stage IIa flatfoot model, but did not change significantly after the medial column stabilization in stage IIb model. (2) After medial column fusion, the stress of the corresponding joint was reduced, but increased for the other joints of the first metatarsal column. (3) The stress of medial ligament and plantar fascia was not alleviated after medial column fusion. (4) These results indicate that simple medial column stabilization surgery cannot reduce the pressure of medial column of flatfoot in stage II acquired flatfoot adults. It can only be used as a combined surgery to stabilize joints with excessive motion and correct the deformity of supination of forefoot.

50Gy gave better survivals.Conclusion Age,tumor histology,ex- tent of resection,interval time of postoperative radiotherapy and the dosage of target were related to survival.

24 hours) and versus control group(