ObjectiveTo study a standardization to establish data element in medical data resource share.MethodsThe library of data element's structural glossary items was established frist, then whole data element was established by selecting structural glossary items, finally, the input of data element's character was executed.ResultsA standardization method to establish data element was desigened based on definition, structure and national standard of data element.ConclusionIt's a important work to share medical data resource that establish data element by standardization, and it must be followed correlative standard and select logical method.

ObjectiveTo study the application of Metadata in search and find data with different structue in medical data resources share.MethodsStudy the definition and character of metadata, establish the metadata standard and directory service system to execute the data search service.ResultsThe Directory Service System based on the method of metadata has been developed, in which the data search service can be realized. ConclusionThe Directory Service System based on the method of metadata has been developed, in which the data search service can be realized. Conclusions It's a effective way to search and find data with different structue using method of metadata, and it is a important way to realize medical data resource share.

Acupuncture manipulation is an important part of the theory of acupuncture and moxibustion, and it is a basic skill for acupuncture physicians. In order to further disclose the essence and character of acupuncture manipulation, the scholars collect in time acupuncture manipulations by the multi-subject crossing methods for qualitative, quantitative analysis and study, and make its analysis of dynamics and kinematics with the riper engineering. However, the current study and analysis on acupuncture manipulation is not deep and not systemic, so the thesis proposes a research way which should create a database of the acupuncture manipulation, so as to provide reliable evidences for studies of correlativity between acupuncture manipulation and acupuncture effects, and establish the theoretical basis for the study of the quantification and standardization of acupuncture manipulation.
Acupuncture Therapy ; instrumentation ; methods ; Humans

This paper introduces the technology of recognizing CD4 cell by a computer, which successfully segments the objects from the background through image processing and analyses the four features including geometric features, optical density, color and texture features. The method based on Principal Component Analysis algorithm is used for feature extraction, and a Back Propagation neural network classifier is constructed, from which the CD4 cell can be well recognized. CD4 cell, image segmentation, feature analysis, Principal Component Analysis (PCA), Back Propagation (BP) neural network classifier is constructed, from which the CD4 cell can be well recognized.
Algorithms ; CD4-Positive T-Lymphocytes ; cytology ; Image Processing, Computer-Assisted ; Microscopy ; methods ; Neural Networks (Computer) ; Principal Component Analysis

Powder X-ray diffraction (PXRD) technology combined with cluster analysis method was used to classify 75 batches of crystalline ceftriaxone sodium into subtypes, the crystalline characteristics of each subtype were measured with scanning electron microscope (SEM). By comparing some parameters of these subtypes correlated to crystallization process of ceftriaxone sodium, such as salification rate, water content in different subtypes, as well as by studying different lattice stabilities, different compatibilities with rubber closures during accelerated stability tests, the key point to improve the quality of domestic ceftriaxone sodium was disclosed. The results of this paper indicated that the fine structure of the products could be controlled well by improving the salification and crystallization process. As a result, the subtype II of ceftriaxone sodium with high stability can be produced.
Ceftriaxone ; chemistry ; classification ; Crystallization ; Microscopy, Electron, Scanning ; Powders ; Water ; X-Ray Diffraction

In order to screen the inhibitors of GAT1 protein, the effects of synthetic N-acylglucosamines on the GABA uptake activity of GAT1 were examined in the HEK-293 cell model stably expressing GAT1 by performing GABA uptake assay. And since the N-linked oligosaccharides, especially their terminal sialic acid of GAT1 are necessary for the function of GAT1, their effects on the modification of N-glycans of GAT1 were also determined by the quantitative analysis of the sialic acid of GAT1. The results showed that 10 mmol /L 3-O-methyl-N-acetylglucosamine(3-O-Met-GlcNAc)reduced the GABA uptake activity of GAT1 to 53%(P< 0. 01)through inhibiting the sialylation of GAT1(66. 8%). And the GABA uptake activities were decreased to 54%, 63%, 63% and 67%(P< 0. 01), respectively, by the treatments of 10 mmol /L N-propionylglucosamine(GlcNProp), N-hexanoylglucosamine(GlcNHex), N-cycloproylgormylglucosamine(GlcNCyclo)and N-acetamidoacetylglucosamine(GlcNAc-acetamido)through inhibiting N-glycan trimming. These results indicate that the analogues of glucosamines have great potential in the development of inhibitors of GAT1 activity or sialic acid biosynthesis.

Abstract: Objective To understand the prevalence and influencing factors of major chronic diseases among Kirgiz residents in Aheqi County, Xinjiang, and to provide theoretical basis for the prevention and control of chronic diseases in this area. Methods　The data of residents in Aheqi County, Kizilsu Kirgiz Autonomous Prefecture, Xinjiang in 2020 for health checkup were selected, and the permanent residents of Kirgiz nationality aged ≥18 were selected as the survey objects, and the prevalence of major chronic diseases and their influencing factors were analyzed by Logistic regression model. Results　A total of 21 935 patients were enrolled, and 10 602 patients suffered from chronic diseases with a prevalence rate of 48.33%, including 4 929 cases of hypertension with a prevalence rate of 22.47%, 4 238 cases of obesity with a prevalence rate of 19.32%, 3 610 cases of dyslipidemia with a prevalence rate of 16.46%, 1 632 cases of anemia with a prevalence of 7.44%, and 1 236 cases of type 2 diabetes with a prevalence of 5.63%. The prevalence of hypertension, obesity, dyslipidemia and type 2 diabetes increased with age, while the prevalence of anemia decreased with age (P<0.01). The prevalence of hypertension dyslipidemia and type 2 diabetes was higher in males than in females, and the prevalence of obesity and anemia was higher in females than in males, with statistical significance (P<0.01). Logistic regression analysis showed that 30-<40 years old (OR=1.836, 95%CI: 1.565-2.034), 40-<50 years old (OR=2.916, 95%CI: 2.613-3.255), 50-<60 years old (OR=5.244, 95%CI: 4.651-5.913), 60 years old and above (OR=10.866, 95%CI: 9.533-12.385), government personnel (OR=1.789, 95%CI: 1.405~2.279), professional and technical personnel (OR=1.774, 95%CI:1.372-2.295), the office staff (OR=1.923, 95%CI: 1.418-2.607) occasional alcohol consumption (OR=1.157, 95%CI: 1.055-1.270) and occasional exercise (OR=1.498, 95%CI: 1.238-1.812) were risk factors for chronic disease. Conclusion　The prevalence of chronic diseases among residents in Aheqi County of Xinjiang is at a low level. Local health institutions have strengthened health education and publicity on multiple chronic diseases and the prevention and control of anemia among young and middle-aged women.

OBJECTIVEThe present study is concerning qualitative and quantitative detection of Poria cocos quality based on FT-near infrared (FT-NIR) spectroscopy combined with chemometrics.

METHODThe Poria cocos polysaccharides contents were determined by UV. Transmission mode was used in the collection of NIR spectral samples. The pretreatment method was first derivation and vector normalization. Then principal component analysis (PCA) was used to build classification model and partial least square (PLS) to build the calibration model.

RESULTThe results showed that conventional criteria such as the R, root mean square error of calibration (RMSEC), and the root mean square error of prediction (RMSEP) are 0.944 0, 0.072 1 and 0.076 2, respectively. The misclassified sample is 0 using the qualitative model built by PCA.

CONCLUSIONThe prediction models based on NIR have a better performance with high precision, good stability and adaptability and can be used to predict the polysaccharose content of Poria cocos rapidly, which can provide a fast approach to discriminate the different parts of Poria cocos.

OBJECTIVETo probe into the selection of parameters of electroacupuncture and analyze some problems.

METHODSAnalyze and study on the relevant literature about the application of electroacupuncture in the past 5 years and analyze the parameters of electroacupuncture in the literature in detail.

RESULTSMost of literature paid greater attention to the selection of parameters of electroacupuncture, but different electroacupuncture apparatuses were used with different electroacupuncture parameters.

CONCLUSIONThe selection of the electroacupuncture apparatus and electroacupuncture parameters does not have an unified standard, influencing comparability and reference of experimental and clinical results.

In order to study on the definition domain and their correlated influencing factors about the acupuncture and moxibustion stimulation quantity, electroacupuncture (EA) stimulation quality and intensity, and to probe into the project of quantification of EA stimulation quantity. The authors reviewed the standardization work of EA, summed up the current state of the application of EA and the problems in quantification of the stimulation quantity in clinically control studies, expounded the different opinions and misunderstanding in acupuncture and moxibustion stimulation quantity and analyzed the definition domain and associated factors about acupuncture and moxibustion stimulation quantity and EA stimulation quantity and intensity. After the technical analysis, the calculation methods and formulas of pulse energy, quantity and intensity of EA stimulation were derived. On this basis, several schemes for the quantification of EA stimulation quantity with a certain feasibility and strong maneuverability are proposed.
Electric Stimulation ; methods ; Electric Stimulation Therapy ; methods ; standards ; Electroacupuncture ; methods ; standards ; Humans