9-Nitrocamptothcin(9-NC)is an orally available new type camptothecinanalog with antineoplastic activity that results from inhibition of DNA topoisomerase Ⅰ.In the study we reviewed the feature of the drug,mechanism of action,update studies of preclinical and pancreas cancer clinical trial.

In recent years,nutritional support therapy has been increasingly paid attention to scientific and reasonable using for patients.Based on the recent researches,the hot topics on the nutritional risk screening,nutritional status assessment and preoperative and postoperative nutritional support therapy were analyzed,and the strategies and progresses of nutritional support therapy for the postoperative critically ill patients,obese patients and short bowel syndromes or bowel failure patients were summarized,meanwhile,hot issues on the standardized nutritional support therapy in the perioperative period were explored in this article.

Objective To identify the researchers' productivity,the citation states and the grant patterns of the Chinese Journal of Hepatobiliary Surgery through citation analysis.Methods Articles published in the Chinese Journal of Hepatobiliary Surgery between 2009 to 2012 were collected from the Chinese Science Citation Database.These articles were analyzed with statistics and bibliometrics.The indicators included cooperation degree,core authors,distribution of grant,authors' origin and citation states.Results Of the 1321 papers which were published by the journal during the study period,505 papers were cited 923 times.Of the 1111 first authors,957 (86.14％) published one paper only.There were 154 core authors (13.86％ of first authors),and they published 364 papers (27.55％).There were 14 high-productivity institutes,which published 299 papers (22.63％).According to the geographical distribution,Beijing ranked first with 190 (14.38％) papers.The second was Shanghai with 156 (11.81％),the third was Jiangshu province with 134 (10.14％),the fourth was Zhejiang province with 132 (9.99％),and the fifth was Guangdong province with 101 (7.65 ％) papers.1262 papers were completed by collaborate teams of more than one author.The cooperative rate was 95.53％ and the cooperative degree was 4.67.361 papers were funded by 553 supporting foundations.Conclusions The authors of the Chinese Journal of Hepatobiliary Surgery were geographically widely distributed.Some were core authors with high-productivity.They were highly cited and with good cooperation degree.Beijing,Shanghai,Jiangshu,Zhejiang and Guangdong provinces play important roles in research on hepatobiliary surgery.

The paper introduces the anesthetic journals indexed by SCI-E, moreover a quantitative analysis is performed on the data, instructs anesthetic researchers to submit, search references and subscribe to international anesthetic journals. 22 anesthetic journals have own distinctive characteristics. Anesthetic researchers could choose appropriate journals for submitting based on the quality of their papers and regions.

Objective To investigate the effect of electro‐acupuncture combined with sevoflurane anesthesia on the regula‐tion of acute stress response in docked tails rats .Methods Fifty male SD rats weighing 280-320 g were randomlsy divided into 5 groups(n=10 each):normal group (group Ⅰ) ,model group (group Ⅱ) ,sevoflurane group (group Ⅲ) ,sevoflurane inhalation com‐bined with body acupuncture group (group Ⅳ) and sevoflurane combined with auricular acupuncture group (group Ⅴ) .The groupⅠwas placed in a glass box containing mixture gas with oxygenflow of 30% (flow 2 L/min) without treatment ,the group Ⅱafter docking tail was placed in a glass box containing mixture gas with oxygenflow of 30% (flow 2 L/min) ,the group Ⅲ ,Ⅳ and Ⅴwere placed in the 2% sevoflurane anesthesia box (flow 2 L/min) ,the group Ⅳ was given continuous stimulation at Zusanli (stimu‐lation parameters :3 V ,3 Hz ,2 ms) for 30 min per time ,4 times at intervals of 30 min ,the groupⅤ was given the stimulation at Er‐jian with the same stimulation parameters as the groupⅣ .Rats in each group were killed after treatment and the blood at broken neck was collected for measuring serum corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels by ELISA .The c‐fos protein expression level in hypothalamic tissue was detected by Western blot .Results Compared with the group Ⅰ ,serum ACTH ,CORT levels ,hypothalamic expression of c‐fos protein in the group Ⅱwere significantly increased (P<0 .01) ,compared with the group Ⅱ ,the peripheral blood ACTH ,CORT levels were decreased with statistical difference (P< 0 .05);the ACTH , CORT levels had no statistical difference between the group Ⅲ and Ⅳ(P>0 .05);the ACTH level in the groupⅤ was significantly decreased compared with the groupⅢ(P<0 .05) and the CORT level in the group Ⅴ was also decreased when compared with the group Ⅳ(P<0 .05) .The c‐fos expression in the groupⅢ ,Ⅳ and Ⅴwere decreased compared with the groupⅡ (P<0 .05) ,there were significant difference among the group Ⅲ ,ⅣandⅤ(P<0 .05) .Conclusion In the treatment of sevoflurane inhalation anesthe‐sia combined with compound electrostimulation at Erjian ,its effect on stress response is superior to simple sevoflurane treatment and sevoflurane combined with compound electrostimulation at Zusanli .The regulation mechanism of electro‐acupuncture combined with inhalation general anesthesia on stress may be related with hypothalamus regulating paraventricular nucleus c‐fos protein se‐cretion and affecting the HPA axis .

Color pattern reversal visual evoked potential using black-white and black-red color checkerboard stimuli was performed on 11 eyes with contusion and their opposite normal eyes. The peak time and the amplitude of P1 wave in the eyes with ocular contusion were significantly different from those in the opposite normal eyes, especially stimulated by the black-red checkerboards (P

OBJECTIVE:To evaluate the status quo and the trend of the clinical utilization of antineoplastic assistant drugs in our hospital.METHODS:The utilization of antineoplastic assistant drugs in our hospital between 2001 and 2006 was analyzed statistically in respect of the drug kinds,dosage form,consumption sum and DDDs etc.RESULTS:Both the number of kinds and the consumption sum of antineoplastic assistant drugs increased year on year from 2002 to 2006(except in 2001). Chinese traditional drugs,western medicines and biological products were the top three categories of all the antineoplastic assistant drugs used in our hospital.In terms of consumption sum,Chinese traditional drugs had dominated the first place over the five consecutive years.In terms of DDDs,traditional Chinese antineoplastic drugs,other kinds of antineoplastic adjuvant drugs,antivomit drugs,Shengbaiyao(increasing the number of leucocytes) took the lead.Of all the antineoplastic assistant drugs used,domestic injections took the lead.CONCLUSION:The utilization of the antineoplastic assistant drugs in our hospital was rational on the whole yet the consumption of which increased rapidly,thus strengthened management on which is still needed.

Objective To provide outline for the Research & Development department of hospitals making research strategy by analyzing the quantity of publications and their cited status for the top 20 hospitals in SCI,and top 100 hospitals in domestic publications in 2010.Methods The number of publications and their cited times for the first 20 hospitals in SCI,and the top 100 hospitals in domestic publications in 2010.Results Compared with 2009,the increased number and ratio of publications in SCI for top 20 hospitals were 1061 and 28.35％,respectively.For top 100 hospitals,the average reduced number and the increased number of domestic publications was 20.36.Conclusions The SCI publications from top 20 hospitals increased sharply.The negative growth was showed in the number of domestic articles for top 70 hospitals.The hospitals after the top 70 still maintain a certain growth.In addition,the increase of cited articles was slowly and disproportion.

By searching relevant data from the PubMed database, Chinese National Knowledge Infrastructure (CNKI) database and Wanfang database, a comprehensive analysis and review regarding acupuncture for cerebral ischemia reperfusion injury (CIRI) in recent 10 years were performed. The results showed that acupuncture could inhibit the inflammatory reaction, reduce oxidative stress injury, restrain brain edema formation, inhibit apoptosis, promote neural and vascular regeneration, etc. Acupuncture methods used included electroacupuncture, scalp acupuncture, eye acupuncture and "consciousness-restoring resuscitation needling", etc. The existing problem was that the intervention action of acupuncture was mainly focused on inhibiting inflammatory reaction and oxidative stress injury, and the study on apoptosis and neural and vascular regeneration was needed. It is suggested that from the aspect of multiple target points, the intervention mechanism of acupuncture for CIRI should be systemically studied in the future, which could provide new idea for clinical diagnosis and treatment on ischemic cerebrovascular diseases.
Acupuncture Therapy ; history ; Animals ; Apoptosis ; Brain Ischemia ; history ; surgery ; History, 21st Century ; Humans ; Oxidative Stress ; PubMed ; Reperfusion Injury ; etiology ; history ; physiopathology ; therapy

Stenosis or occlusion of vertebral artery origin is one of important reasons of posterior circulation ischemia. Vertebral artery stenting can reduce posterior circulation ischemia in patients with vertebral artery origin stenosis. Restenosis after stenting is an important reason influencing the long-term efficacy.This article reviews treatment approaches of vertebral artery origin stenosis, restenosis after stenting and the related factors.