The recent development of process analytical chemistry(PAC) in the past years is reviewed. The content includes process measurement, sensor, chemometrics etc. The future of PAC is also discussed. 62 references are cited

Objective To explore the application of multilevel growth model in community intervention research. Methods The data a-bout blood pressure collected through questionnaire at baseline and 6 months, 12 months after intervention were analysed through multilevel growth model to evaluate the effectiveness of hypertension self-management. Results The blood pressures between the two groups were statistical significance at baseline,and the changing trends also were different. Age could affect diastolic blood pressure (DBP) changing after controlling the other factors. Conclusion Multilevel growth model can analyze the longitudinal data acquired from intervention research flexibly,and the result is more reliable.

Objective To discuss an effective and practicable mode of health management service by preventing the dangerous factors from causing diseases for 149 sufferer of chronic metabolic diseases and analyzing the results of such prevention.Methods Set standard examining items for collecting health information,which will be input the health information managing system and then be quantitatively assessed.The number of those who have isolated systolic hypertension and chronic metabolic disturbance disease,including hyperlipemia,hyperglycemia,hyperuricemia and fatty liver is 149.These people will be divided into 5 groups and preventions will be conducted against those dangerous factors which could lead to diseases.The results of such prevention will be assessed later.Results Significant changes have been shown in the observation indexes including blood pressure,total cholesterol(CT),triglycerides(TG),low density lipoprotein cholesterol(HDL-ch),fasting blood glucose(FBG),uric acid(UA),alanine aminotransferase(ALT)and ultrasound scan after the abovementioned preventions.Conclusion The mode of health management service mentioned in this article iS effective and practicable.

To establish a new method for the determination of chondroitin sulfate. The method was based on the interaction of sodium chondroitin sulfate with 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole to yield a violet product, 6-mercapto-3-substituted-s-triazolo-\[4,3-b\]-s-tetrzaine derivatives. Absorbance at 540 nm obeyed Beer's Law within the concentration range from 0.1 to 1.0 g?L~(-1)and the results were precise and accurate. The method was operationally simple and had a good precision and sensitivity.

BACKGROUND: In the process of bone defect repair, as their respective shortcomings, both autograft and al ograft cannot obtain satisfactory outcomes. OBJECTIVE: To observe the effect of soft composite materials for bone regeneration established in vitro in skul defect repair. METHODS: Soft composite materials for bone regeneration (bone morphogenetic protein 7-derived polypeptide, chitosan, nano hydroxyapatite and col agen) were established in vitro. Twenty-four Sprague-Dwley rats were enrol ed to prepare skul defect models, and were randomly equivalently divided into two groups. The rats were repaired with chitosan/nano hydroxyapatite/col agen composite materials as control group, and those repaired with soft composite materials of bone regeneration as experimental group. RESULTS AND CONCLUSION: The soft composite material of bone regeneration exhibited a loose and porous structure and bone morphogenetic protein 7-derived polypeptide was released in a gradual y rising trend. Compared with the control group, bone mineral density of the defect region in the experimental group was higher, which was similar with that of the normal bone tissue, and additional y numerous newborn bones could be found. These results show that the soft bone regeneration composite material exerts a better repair effect in skul defect.

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumors of the diges-tive tract. Along with histology progress, the people have made the new progress regarding the mesenchy-moma understanding, also proposed the new viewpoint to its treatment, the therapy of GIST has changed from surgical resection alone to surgery after the application of tyrosine kinase inhibitor. The article reviews the therapy of GIST and proposes possible therapeutic regimen.

Goal To promote the university student to foster the civilized behavior.Method From September to October,2007,investigate the 615 students of Nursing Department in Our college,in order to know the situations of civilization and manners on campus.Result Amorg the ten big uncivilized behaviors,in the first place is: uncivilized languge,that is,speaking obscene words.The above is the view of 324 students 167 students think that humiliating the small and weak and fighting are the most disgusting behaviors.So how to foster the university student's civilized behavior turns to be a society problem now.Conclusion The coordination of the autonomy and the heternomy can play a better effect during the process of fostering the civilized behaviors.But the autonomy may play a main role in the process.

Objective To compare the effects of continuous veno-venous hemofiltration (CVVH) and intermittent hemofiltration (IHF) on the hemodynamics and clinical outcomes of patients with type 1 cardiorenal syndrome. Methods From May 2008 to June 2011, 34 patients diagnosed with type 1 cardiorenal syndrome were admitted to our hospital and received CVVHQ9 cases) or IHF (15 cases). The general data, acute hemodynamic changes before and after hemofiltration and clinical outcomes at 28 days after hemofiltration were evaluated. Results There were no significant differences in the heart rates, diastolic blood pressure between the two groups before and after hemofiltration (P>0.05). The systolic pressure was similar between the two groups before hemofiltration (P>0.05), but that in the IHF group was significantly lower than that in the CVVH group after hemofiltration (P<0.05). No significant difference was found in the maximal mean pressure or blood pressure changes between the two groups at 48 h after hemofiltration(P>0.05), but the minimal mean pressure in IHF group was significantly lower than that in the CVVH group (P<0.05). The improvement of cardiac function and the mortality rates at 28 d after hemofiltration were not significantly different between the two groups(P>0.05). Multivariate analysis suggested that APACHE II was the main influence factor of 28-day mortality of patients, and APACHE II and net ultrafiltration were the main influence factor of the minimal mean pressure. Conclusion Compared with IHF, CVVH fails to greatly reduce the mortality of patients with type 1 cardiorenal syndrome. The severity of the disease is the main influence factor for the hemodynamic changes and the 28-day mortality of patients with type 1 cardiorenal syndrome.

ObjectiveTo investigate the mentation of the female in mammography examination. Methods292 female patients (over 35 years old) from the out-patient department accepted the psychological questionnaire survey.ResultsMost female patients showed some mental problems, include angst, discomposure, tension or funk for examination. They worried about examination result and the damage being exposed to the X-ray irradiation.ConclusionTechnicians should pay attention to the mentation of the female in mammography examination to win their trust and cooperation.

Objective To investigate the clinical value of Color Doppler Ultrasound in diagnosis of lymph node diseases. Methods We observed the ultrasound features of the 93 cases of swelled lymph nodes with Color Doppler ultrasound. The ultrasound features included pseudokidney sign, assessment on blood flow distribution, the Doppler resistive Index (RI), maximal flow rate (Vmax),the longitudinal axis compared to the diameter of a node (L/D ratio) . Results Out of 93 cases of clinically confirmed swelled lymph nodes,the concordance rate of Color Doppler Ultrasound was 86%and 88%in diagnosis of malignant lymph node disease and benign lymph node disease, respectively. 4 cases of lymph tuberculosis were misdiagnosed as lymphoma due to the similar ultrasound characteristics found in malignant lymph group,the rate of misdiagnosis was 8%. In the cases of proliferative lymph node diseases with Pseudokidney sign, 93% of the blood flow distribution was classified as grade 0-I. 90% of lymphadenitis were found with Pseudokidney sign,and 95%of those cases with blood flow distribution was classified as grade II-III. Malignant lymph diseases had no Pseudokidney sign, and 86%of blood flow distribution grade was as III. There was statistically significant difference in the L/D ratio and RI between benign lymph group and malignant lymph group (P<0.01) . There was statistically significant difference in Vmax between lymphoproliferative group and other groups (P<0.01) . Conclusions Pathological characteristics on different lymph node disease determin the ultrasound characteristics. Combined clinical data based on Pseudokidney sign, Blood Flow Distribution, RI value,Vmax value and L/D ratio can enhance the accuracy of various lymph node disease diagnosis.