1.Clinical Diagnostic Value of CT Scan and Serum Tumor Markers Determination for SCLC
Chunfeng HU ; Xu WANG ; Kai XU ; Xiuling WANG
Journal of Practical Radiology 1992;0(11):-
Objective To investigate the clinic diagnosis value of CT scan and the determination of serum NSE, Cyfra21-1 for SCLC. Methods ① The CT findings and pathologic basis of 220 cases with SCLC were analyzed retrospectively.② Between February 2000 and December 2001, 120 consecutive patients with pulmonary lesions by CT scan, which suspiciously suffered lung cancer, were studied prospectively. Serum samples were obtained by venous puncture from all patients 1 week prior to surgery or puncture biopsy. The serum concentration of NSE, Cyfra21-1 were determinated using ELISA. According to the pathologic result, the diagnostic value of CT scan, NSE and Cyfra21-1 were evaluated.Results ① Most CT findings of SCLC were central and spindly or eggplant-shape mass, hilar and/or mediastinal lymph nodes enlargement.The obstructive pulmonary lesions were found rarely.② Using CT scan, NSE and Cyfra21-1 alone, the sensitivity were 75%,72.5% and 32.5%,the specificity were 73.75%, 83.75% and 48.75%,the accuracy were 74.16%, 81.67% and 43.33% respectively. With combination of CT scan and NSE, the diagnostic accuracy was 78.3%, and the sensitivity was 87.5%. However, CT scan combined with Cyfra21-1 can not be improve the diagnostic value. Conclusion SCLC has specific CT findings. The sensitivity of CT scan was 75%, combinated with NSE, its accuracy was higher(78.3%), and the sensitivity was 87.5%.
2.Dynamic modeling and simulating of squatting-standing action of human body.
Jianhui WANG ; Xiulin XU ; Meijun AN ; Xiufang HU
Journal of Biomedical Engineering 2014;31(6):1250-1254
It is very difficult for stroke patients to complete the action of squatting-standing because their equilibrium function ability has been seriously declined. It was necessary, therefore, to do a deep research on the action of human squatting-standing and to set up an accurate model and simulation. In our modeling research, the movements of upper limbs and head was neglected, and a seven-segment model was developed to establish the coordinate system of human squatting-standing action. It calculated the knee joint moment and hip joint moment during squatting and standing by utilizing Lagrange method, and then simulated this mathematical model by utilizing Matlab. Geometric model of human squatting-standing was developed and simulated in ADAMS which proved that the established Lagrange model was reasonable. It would also provide significant theoretical references for further study and development of squatting-standing rehabilitation training equipment.
Biomechanical Phenomena
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Computer Simulation
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Hip Joint
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Humans
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Knee Joint
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Models, Theoretical
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Movement
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Posture
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Upper Extremity
3.Naringin reduced polymethylmethacrylate-induced osteolysis in the mouse air sacs model.
China Journal of Orthopaedics and Traumatology 2015;28(4):345-349
OBJECTIVETo evaluate the influence of naringin on PMMA-induced osteoclastic bone resorption using the mouse air sacs model.
METHODSTotal 48 female Balb/c mices with the age of 8 to 10 weeks were chosen in the study. Air were injected into the back in 32 mices and formed the air sacs, 6 d later, the skulls (originated from other 16 mices) were implanted to the air sacs. Thirty-two animals were divided into naringin treatment group (with 2 concentrations of 150 mg/kg and 30 mg/ kg) , DMSO group and PBS blank group, 8 animals in each group. Polymethylmethacrylate (PMMA) particles were injected into the air sacs in naringin treatment groups and DMSO group so as to irritate inflammatory reaction. Naringin with 2 concentrations of 150 mg/kg and 30 mg/kg were dissolved in DMSO of 0.2 ml, and were injected into air sacs, respectively. In PBS black group, no stimulation with PMMA particles, only injected PBS, and in DMSO group, injected DMSO without naringin. Tartrate resistant acid phosphatase (TRAP), Ca2+ release, modified Masson stain and histological analysis were performed on the 7th day after stimulation.
RESULTSCompared with DMSO group, naringin treatment group's cellular infiltration decreased (P < 0.01); concentration of 150 mg/kg was better than that of concentrations of 30 mg/kg (8.90 ± 1.75 vs 15.23 ± 1.86). Naringin can decrease calcium release in the lavage of the air sacs bone resorption model, especially obvious in naringin with concentration of 150 mg/kg. Naringin can ameliorate the inflammatory reaction and the subsequent bone resorption (including bone collagen loss, TRAP positive cells amount and so on) in air sacs with bone implant and PMMA particles. Naringin with concentration of 150 mg/kg appeared to be an optimal dosage to deliver the therapeutic effects.
CONCLUSIONNaringin inhibits PMMA-induced osteoclastogenesis and ameliorates the PMMA-associated inflammatory reaction and the subsequent bone resorption.
Animals ; Disease Models, Animal ; Female ; Flavanones ; therapeutic use ; Mice ; Mice, Inbred BALB C ; Osteoclasts ; drug effects ; physiology ; Osteolysis ; chemically induced ; prevention & control ; Polymethyl Methacrylate ; toxicity
4.Therapeutic effects of sodium cholate, lactulose and anisodamine on endotoxemia in patients with obstructive jaundice
Dezheng XU ; Mingrong HU ; Xiong WANG
Chinese Journal of Hepatobiliary Surgery 1998;0(06):-
0.05) while the level was significantly higher in the former 4 groups than in the control (P
5.Study on Dissolution Test Methods for Diclofenac Sodium Suppository
Chuhong XU ; Yongning LU ; Hu WANG
China Pharmacy 2001;0(07):-
OBJECTIVE:To establish a good method for determining the dissolution rates of diclofenac sodium suppository METHODS:The dissolution method Ⅰ and Ⅱ of ChP(2000) were compared,the first derivative spectrophotometry was used and the parameters(T50,Td,m) obtained from these samples were brought for correlation analysis RESULTS:The dissolution rate of diclofenac sodium suppository from the dissolution method Ⅰ and Ⅱ were remarkably different,and the dissolution method Ⅱ was better than Ⅰ CONCLUSION:The method established by this study is suitable for the quality control of diclofenac sodium suppository,and the percentage of dissolution of diclofenac sodium suppository in 45min more than 80% is the standard of quality control
6.Ethical consideration on the TWO average expense control
Jianyong HU ; Mingyuan WANG ; Linfeng XU
Chinese Medical Ethics 1994;0(06):-
TWO average expense control(TAEC) is the method that the hospital want to control the increasing breadth of medicine expense by limiting the total expense which include both clinic expense and hospitalize expense.TAEC will fake great help to improve the relationship of docfor and patient and to promote the hospital work.But the method of TAEC will also to be optimize further.
7.The Application of Distortion Product Otoacoustic Emission to Assessing Children with Otitis Media with Effusion
Yanling HU ; Zhinan WANG ; Zhongqiang XU
Journal of Audiology and Speech Pathology 1998;0(02):-
0.05),but the difference was significant at high frequency(P
8.Changes of plasma endotoxin on renal damage in patients with obstructive jaundice before and after operation
Mingrong HU ; Dezheng XU ; Xiong WANG
Chinese Journal of General Surgery 1993;0(02):-
Objective To study the relationship of plasma endotoxin (ET) level and renal function damage in patients with obstructive jaundice(OJ). Method The level of plasma ET、creatinine (Cr) or blood urea nitrogen ( BUN ) and endogenous creatinine clearance rate (Ccr ) were determined before and after operation in 30 patients with OJ(OJ group), and 21 cases of chronic cholelithiasis without jaundice (control group). Results The plasma ET level of peripheral blood was increased more significantly (P
9.Analysis the Parameter of the Peripheral Blood Cells of Patients with Cirrhosis of Liver
Yangqian HU ; Ziqiang WANG ; Zhang XU
Journal of Chinese Physician 2001;0(10):-
Objective To discuss the clinical relationship between changes of the parameter of the peripheral blood cells and liver cirrhosis.Methods The parameter of the peripheral blood cells of 321 patients with cirrhosis of liver was analyzed.Results Changes of the parameter of the peripheral blood cells of patients with liver cirrhosis were abnormal obviously.Changes of Hb,RBC,HCT and RDW were well correlate to the degree of impairment of liver function.With the progression of impairment of liver function,Hb RBC and HCT decreased,RDW increased gradually in patients with liver cirrhosis(P
10.Determination of myocardial enzymes to assess acute CO poisoning-induced myocardial damage.
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(6):469-470
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Carbon Monoxide Poisoning
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enzymology
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Case-Control Studies
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Female
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Humans
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Male
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Middle Aged
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Myocardium
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enzymology
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Young Adult