1.Clinical observation of toothpaste containing zanthoxylum nitidum extract on dental plaque and gingivitis.
Hu-chun WAN ; De-yu HU ; Hong-chun LIU
Chinese Journal of Integrated Traditional and Western Medicine 2005;25(11):1024-1026
OBJECTIVETo observe the clinical efficacy of drug toothpaste containing 2% Zanthoxylum Nitidum extract in reducing accumulation of dental plaque and occurrence of gingivitis in adults.
METHODSAdopting double-blind, stratified and parallel design, the status of dental plaque and gingivitis in 200 healthy adults enrolled in the trial (100 in the treated group took the drug toothpaste to clean teeth, and 100 in the control group use common toothpaste instead) were assessed at before experiment, 3 months and 6 months after experiment.
RESULTSAt the end of the 3rd month and the 6th month, as compared with the control group, the L e-Silness Gingival Index (GI) in the treated group was decreased by 9.1% (P > 0.05) and 13.9 % (P< 0.5), in the same period, the Quigley-Hein(Turesky Modification) Plaque Index (PlI) decreased by 18.7% and 22.6% (P<0.05), respectively.
CONCLUSIONToothpaste containing Zanthoxylum Nitidum extract can obviously decrease the incidence of dental plaque and enhance gingival health.
Adolescent ; Adult ; Aged ; Dental Plaque ; drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gingivitis ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy ; Toothpastes ; chemistry ; Zanthoxylum ; chemistry
2.Effect of Postoperative Continuous Epidural Analgesia with Sufentanil in Different Concentrations and Combined with Bupivacaine on Pain after Thoracotomy
Chun WANG ; Yue SU ; Wan-ming GENG ; Hui ZHENG ; Wei LIU ; Guangkuo GAO ; Zhengfang HU
Chinese Journal of Rehabilitation Theory and Practice 2006;12(4):352-354
ObjectiveTo observe the effect and safety of continuous epidural analgesia with sufentanil in different concentrations combined with 0.125% bupivacaine on pain after thoracotomy.Methods30 patients with ASA grade Ⅱ~Ⅲ and underwent thoracotomy were randomly divided into 3 groups treated with 0.125% bupivacaine combined with sufentanil 0.25 μg/ml (group A), 0.50 μg/ml (group B) and 0.75 μg/ml (group C) respectively. Before operation starting, epidural puncture was performed at T7~T8 and a catheter was put in. After operation, continuous epidural analgesia was performed by connecting the catheter and a analgesic pump. Analgesia effect was evaluated by visual analogous score (VAS) at sixth, twelfth, twenty-fourth and forty-eighth hours after operation. Dosage of assistant drug and side effects such as calmness, nausea, vomiting, skin pruritus and respiratory inhibition were also recorded.ResultsVAS scores and dosage of assistant drug of group B and group C were not different, but they were all lower than that of group A (P<0.05). Scores of skin pruritus of group A and group B were lower than that of group C (P<0.05), but there was no significant difference between group A and group B. No respiratory inhibition occurred in patients of all three groups.ConclusionContinuous epidural analgesia of 0.50 μg/ml sufentanil combined with 0.125% bupivacaine is safe and effective for patients after thoracotomy.
3.Analysis on disease burden of occupational coal workers′ pneumoconiosis in Anhui Province
HU Qiong CHEN Bao chun HU Xun jia XIE Qiao mei ZHA Wan sheng SONG Yuan chao
China Occupational Medicine 2022;49(06):635-639
Objective
To analyze the disease burden caused by occupational coal workers' pneumoconiosis (CWP) in Anhui
Methods
Province. A total of 1 649 patients with occupational CWP diagnosed in Anhui Province from 1950 to 2019 were
selected as the study subjects using a retrospective study method. Age, gender, survival time, location, working age of disease
onset, age of death, stage and date of diagnosis of CWP, comorbidities at the time of investigation, hospitalization and outpatient
expenses in the past year, cost of absence from work, cost of absence from work of caregivers, and cost of nutrition and
transportation were investigated. The years of life lost, years lived with disability (YLDs), disability adjusted life years (DALYs)
Results
and economic losses were calculated. Among these patients, 1 405 cases survived and 244 cases died. In the age range
- - -
of 20.0 70.0 years, the YLDs of surviving patients were 2.12 22.20 (8.19±3.59) person years. The YLDs of patients with disease
vs - P
complications was higher than that of patients without complications [(8.55±3.95) (7.87±3.21) person years, <0.01]. The total
- -
DALYs of the patients was 14 031.59 person years, and the average per capita DALYs was 8.51 person years. Its YLDs
accounted for 82.0 % of the total DALYs. The total economic loss caused by CWP in the 1 405 surviving patients was 354.903 0
Conclusion
million yuan, and the average per capita economic loss was 252 600 yuan. The disease burden caused by CWP is
relatively high in Anhui Province. In addition to early detection, diagnosis and treatment, it is necessary to focus on prevention
and treatment of CWP complications to reduce the disease burden.
4.Stomatological disaster medicine in earthquake rescue.
Hu-chun WAN ; Qian LIU ; Min WANG ; Xue-dong ZHOU
West China Journal of Stomatology 2008;26(4):343-357
This article is to explore how to participate disaster medical rescue. Specific cases, concerned experiences and effects obtained from the big earthquake occurred in Wenchuan, Sichuan Province May 12, 2008 were presented for researching consideration. According to conclusion of this report, it is urgently necessary and vitally important for stomatologists to study disaster medicine rescue.
Disaster Medicine
;
Disasters
;
Earthquakes
;
Humans
;
Oral Medicine
5.Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia.
Chun-Lian LIU ; Hai-Yan JIAO ; Qiang MA ; Xing WU ; Shao-Tong JIA ; Wan-hong JING ; Qing-Hu YANG
National Journal of Andrology 2014;20(5):419-422
OBJECTIVETo explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.
METHODSUsing MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.
RESULTSThe ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).
CONCLUSIONThe ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.
Adult ; Case-Control Studies ; China ; DNA Repair ; Genotype ; Humans ; Infertility, Male ; genetics ; Male ; Polymorphism, Single Nucleotide ; Xeroderma Pigmentosum Group D Protein ; genetics
6.Atraumatic restorative treatment restorations placed in school children.
De-Yu HU ; Hu-Chun WAN ; Hong-Chun LIU ; Xue LI ; Xu FAN ; Edward C M LO
Chinese Journal of Stomatology 2004;39(1):34-37
OBJECTIVETo assess the long effect of atraumatic restorative treatment (ART) restorations in a school environment.
METHODSFive middle-level dentists placed 294 ART restorations in the permanent teeth of 197 children. Standard instruments and procedures for ART were used. The restorative material used was a high-strength glass-ionomer. The restorations were evaluated annually by the same examiner who was not involved in the placement of the restorations. Occlusal wear of the restoration was assessed using a standard rheinberger scale. At the 5th year examination an independent external examiner evaluated the restorations using USPHS criteria.
RESULTSThe cumulative survival rates of small class I restorations in the sixth year it was 75%. The corresponding figures for large class I restorations were 61% (P < 0.05). The net wear rate for both the small and large class I restorations in the first year was about 48 microm, which was significantly higher than those of the later years, which were about 20 - 25 micro m (P < 0.05). In the fifth year 93% of the small restorations were assessed as being satisfactory for marginal integrity, as against 80% for the large ones by using USPHS criteria.
CONCLUSIONSThe ART approach for treating tooth decay in school children was appropriate, effective and acceptable. The 6-year survival rates of the restorations are high but are related to the size and type of the restoration.
Adolescent ; Child ; Dental Restoration, Permanent ; Glass Ionomer Cements ; Humans ; Prospective Studies
7.Effect of decoction of Radix glycyrrhizae on the growth and acid-production of Streptococcus mutans in vitro.
Fei-fei ZHANG ; Yong-hong HE ; Yan-li WEN ; Qin-rui MA ; Guo LIU ; Hu-chun WAN
West China Journal of Stomatology 2009;27(5):542-544
OBJECTIVETo investigate the antibacterial activity of decoction of Radix glycyrrhizae against Streptococcus mutans (S. mutans) in vitro.
METHODSThe decoction of Radix glycyrrhizae was prepared by boiling particles of Radix glycyrrhizae, the diameter was 0.2-3.2 mm. In distilled water and filtered, the filtrate was collected for study. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of the decoction against S. mutans were detected using double dilution. The effect of decoction on growth and acidogenic profile of S. mutans were investigated by detecting the Abs of bacteria suspension and the pH value of medium at definite time intervals(0, 3, 7, 12, 23, 40 h) during cultured.
RESULTSThe MIC determined for decoction was 50 mg x mL(-1) and there was no bactericidal effect when concentration of decoction lower than 100 mg x mL(-1). The decoction inhibitted multiplication of bacteria significantly and the effects became stronger with concentration increasing. The decoction also inhibitted S. mutans producing acid and the effect became stronger with concentration increasing. The most efficient inhibition were observed when incubated 12 hours.
CONCLUSIONThe decoction of Radix glycyrrhizae can inhibite the growth and acid-production of S. mutans in vitro.
Anti-Bacterial Agents ; Bacteria ; In Vitro Techniques ; Microbial Sensitivity Tests ; Plant Extracts ; Streptococcus mutans
8.Study on protein extraction methods for Streptococcus mutans.
Yong-hong HE ; Xiao-bei TIAN ; Hu-chun WAN ; Yan-li WEN ; Fei-fei ZHANG ; Qin-rui MA
West China Journal of Stomatology 2009;27(1):100-103
OBJECTIVETo establish an efficient and stable method for protein extraction of Streptococcus mutans.
METHODSThe collected bacteria were treated by freeze-thaw and ultrasonic (method 1), ultrasonic (method 2), boiling (method 3), boiling and ultrasonic (method 4), respectively. The index such as state of bacteria broken, concentration of extracted protein and SDS-PAGE of protein were employed to evaluate the effects of above four methods.
RESULTSBeside the method 3, the other three methods could break the bacteria effectively, of which ultrasonic was the key factor. The pattern of SDS-PAGE which treated by method 1, method 2 and method 4 was almost same, but method 1 resulted in the best abundance. There was significantly difference among the four protein concentration extracted by four methods (P < 0.05). All methods exhibited good stability and reproducibility.
CONCLUSIONMethod of freeze-thaw and ultrasonic resulted in an efficient proteins extraction of Streptococcus mutans which demonstrated good stability and reproducibility and easy to handle.
Bacterial Proteins ; Reproducibility of Results ; Streptococcus mutans
9.Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression.
Qing MENG ; Hyoung Chun KIM ; Seikwan OH ; Yong Moon LEE ; Zhenzhen HU ; Ki Wan OH
Biomolecules & Therapeutics 2018;26(5):425-431
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and γ-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an anti-depressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.
Central Nervous System
;
Depression*
;
Dopamine
;
Drug-Seeking Behavior
;
Microinjections
;
Motor Activity
;
Neurotransmitter Agents
;
Phosphotransferases
;
Receptors, Dopamine
;
Receptors, Glutamate
;
Receptors, Neurotransmitter
;
Transcription Factors
10.A survey on knowledge and habits of oral health in freshmen of Sichuan University.
Shu MENG ; Ya-fei WU ; Hu-chun WAN ; Chun TAN ; Jiao HUANG ; Yong-hua GUO ; Lei ZHAO
West China Journal of Stomatology 2004;22(6):519-520
OBJECTIVETo investigate the oral health knowledge and habits of freshmen of Sichuan University and promote the prophylactic therapy of dental diseases in the university.
METHODSThe table and the standard on oral health survey authorized by WHO were employed in this study.
RESULTSOnly 13.1% of all the investigated freshmen had periodic oral health examination. 74.4% brush teeth twice per day, only 7.7% brush teeth over 3 minutes, 16.6% insist in fluoridated toothpaste, and only 6% had applied dental floss. 51.9% do not often take snack food and 94.7% are non-smokers; (4) Tests of prophylactic therapy of dental caries and periodontal diseases and oral health knowledge have poor results.
CONCLUSIONThe freshmen have limited knowledge of oral health and lack serious attitude toward oral cleaning behaviors.
Health Knowledge, Attitudes, Practice ; Humans ; Oral Health ; statistics & numerical data ; Oral Hygiene ; statistics & numerical data ; Students ; Universities