Sepsis,a common clinical syndrome,comparing to septicaemia or bacteremia,has a more comprehensive pathophysiological process.Its pathogenesis is complex,including pro-inflammatory/anti-inflammatory cytokine imbalance,intestinal bacterial translocation,immunosuppression,signal pathway activation,etc.Further study on the pathogenesis of sepsis is the theory foundation to explore the new method of sepsis.The diagnosis of sepsis pathogenesis,treatment principles and common virus infection induced sepsis are reviewed in this paper.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; therapy ; Humans ; Medicine, Chinese Traditional ; Phytotherapy

OBJECTIVE:To provide reference for choosing appropriate methods of health outcome measurement in phar?macoeconomic evaluation.METHODS:To compare different outcome measurement methods and introduce the standards in varied pharmacoeconomic guidelines.RESULTS&CONCLUSION:We should choose those methods according to different health systems,angles of research and disease specialities.

OBJECTIVE: To provide reference information for formulating drug policies in China.METHODS: To introduce the development and application of pharmacoeconomics in drug pricing and reimbursement process in Asia - Pacific region. RESULTS & CONCLUSION:Pharmacoeconomics can aid for drug policy decision.

During 1920-30s,under the push of Kuomintang,Communist Party and social personage,the Chinese village launched a cooperation movement. Although they failed to renew rural areas in China,the farmer autonomy spirit, policy practicality,the educational principles,and the spirit of evidence-based demonstration research embodied in the movement still have an enlightening significance to the construction of the new rural cooperative healthcare system and construction of new-type villages.

Obesity is a major risk factor for the generation and development of diabetes, atherosclerosis, hyperlipidemia and cancer. Obesity is accompanied with remodeling of adipose tis-sue, such as changed cell component and function, angiogene-sis, extracellular matrix remodeling and infiltration of inflamma-tory cells. It is important for the prevention of obesity to study adipose tissue remodeling. This review summarizes recent ad-vances in adipose tissue remodeling.

Induced pluripotent stem (iPS) cell based on recently developed stem cell reprogramming technique holds great hope for regenerative medicine,in vitro disease modeling and drug evaluation.Recent progress on clinical hematology includes in vitro generation of hematopoietic progenitors and mature blood cells from somatic cells,iPS cells derived from chronic myeloid leukemia cells for the better understanding of the resistance mechanisms of bcr-abl inhibitor imatinib,and moreover,correction the monogenic inherited disease using gene-targeted strategies.However,whether the iPS cells can fully replace human embryonic stem cells still needs further investigation.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B ; complications ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy ; etiology ; Medicine, Chinese Traditional ; Phytotherapy

The pericarp (1), aleurone layer (2), scutellum (3) (including the epiblast), embryo (4) (including radicle and plumule), and the outer (5) and inner (6) endosperm of two samples of kaoliang grain were separated by dissection. The ratio of the weight between the outer and the inner portions of endosperm is about 1:2.4. The contents of thiamin, riboflavin, nicotinic acid, total protein and xylose and the weight were determined separately for each part as well as for the whole grain.The results of analysis are given in Table 1 and the percentage distribution of the weight and the content of different nutrients of the whole grain in each part are shown in Table 2.More than 90％ of thiamin is present in scutellum and embryo, although the sum of their weights represents only about 10％ of the whole grain. The amount of this vitamin in the endosperm, the main portion of the polished grain, is only about 3％. Similar to the results obtained from other grains, the content of vitamin B_1 in the outer portion of the endosperm is higher than that in the inner part.The riboflavin content in the endosperm is about one fifth to one eighth of the other parts of the grain; owing to the high proportion of its weight, the percentage of riboflavin in the whole grain present in endosperm is about 30％. Thus the distribution of this vitamin is comparatively more even than that of thiamin and nicotinic acid.Nicotinic acid is largely concentrated in the aleurone layer. It is interesting to note that the content of this vitamin in the two samples of kaoliang is not the same, sample Ⅱ containing only about 70％ of that in sample Ⅰ. This difference can be almost entirely attributed to the difference in the quantity present in the aleurone layer. The content of nicotinic acid in other parts of the grain is similar in both samples tested.The total nitrogen content in the embryo is much higher than that in other parts of the grain. The amount present in the inner part of the endosperm is considerably lower than that in the outer part.Xylose is largely concentrated in the pericarp and the aleurone layer, which together represent about 70％ of the xylose content in the whole grain.

OBJECTIVE:This article discusses the development of a new commodity flow pattern,acting delivery,in Chi?nese pharmaceutical circulation.METHODS:Using comparative method to analyze the reasons,the operating framework and the present strategies on developing acting delivery.RESULTS&CONCLUSION:The new pattern of acting delivery is con?ducive to reduce pharmaceutical circulation cost,to strengthen enterprises'competitiveness and to use social resources more rationally.That is an inevitable development tendency for Chinese pharmaceutical circulation market and for following inter?national practice.