Objective To compare the clinical effect of hypertensive intracerebral hemorrhage treated by small bone window craniotomy or craniotomy.Methods 192 cases of patients with hypertensive cerebral hemorrhage treated were selected and divided into minimally invasive group and flap group randomly.Small bone window craniotomy was used in minimally invasive group,while large trauma craniotomy was used in flap group.Complications,rebleeding and short and long term efficacy were recorded and compared.Results 6 cases(6.3％) of.incidence of complications in minimally invasive group,while 14 cases(14.56％) in flap group,the rate in the former group was lower than that in the latter group (x2 =51.308,P ＜ 0.05).There was no significant difference of rebleeding between the two groups (P ＞ 0.05).3 weeks later,GCS score was (10.9 ± 1.8),GOS score (3.3 ± 0.6),BI index (47.8 ±11.5) and 64 cases' nerve function improved (66.7 ％) in minimally invasive group,while GCS score (10.1 ± 2.5),GOS score(2.7 ±0.8),BI index (33.5 ± 15.4) and 31 cases' nerve function improved(32.3％) in flap group.The GOS score,BI index and the situation of nerve function improvement were better in minimally invasive group than that in flap group(t =15.758,56.529,x2 =72.149,P ＜0.05).None of the patients were dead,and there were no significant differences of GCS score between the two groups(P ＞0.05).6 months later,no significant difference of GCS score and mortality were found between the two groups (P ＞ 0.05).but the mean score of GOS and BI index were higher than those in flap group (t =11.647,32.990,P ＜ 0.05).Conclusions Both large trauma craniotomy and small bone window craniotomy could reach therapeutic purposes.However,intraoperative and postoperative complications could be deceased by small bone window craniotomy,and short and long term GOS score and BI are higher,the short term nerve function improvement is better.

Early detection of HCC is critical for a good prognosis. Therefore, the development of tumor markers that can detect HCC at even earlier stages is urgent. Recent researches show that the human cervical cancer oncogene, gamma-glutamyl transferase mRNA, human telomerase reverse transcriptase mRNA, the proteins such as glypican-3, golgi protein 73, vascular endothelial growth factor and transforming growth factor-β1 could serve as markers for early detection of HCC.

Colon carcinoma is one of the most common malignant neoplasms.The incidence of this disease has been increasing significantly in recent years in China.Ahhough diagnostic and therapeutic methods have been im proved greatly.carcinoma invasion and metastasis are considered to be the main causes of poor prognosis and death. Tumor metastasis is a complicated process with multiple steps and factors.Cell adhesion molecule(CAM)play a very impntant role in this process while it expresses exceptionally or loses its function.CAM is a kind of glycopro tein molecule by the cell synthesis which mediates the intereontact and intercombination between cell and cell or be tween cell and matrix.It takes part in a series of important physiologic and pathologic processes,such as cell signal conduction and activation,cell extension and migration,tumor metastasis and wound healing,and so on.

Biliary atresia(BA) is a serious digestive system disease caused by the obliteration of intrahepatic and extrahepatic biliary system of infancy.Without prompt treatment,BA can cause biliary cirrhosis,and ultimately cause liver failure,leading to death.The early diagnosis of BA is crucial to the early treatment.At present,liver biopsy is considered to be the gold standard of diagnosis of BA,but this method has some shortcomings such as invasive,repeated sampling and subjectivity.In contrast,ultrasonography (US),magnetic resonance imaging (MRI) and hepatobiliary scintigraphy(HBS) gradually play important roles in clinical diagnoses of BA and become the hotspot of BA diagnoses.This paper focuses on reviewing the clinical applications of BA imaging diagnoses and the latest research progress.

Objective To analyze post-traumatic growth of Chinese caregivers of dementia patients and to explore the caregivers′positive and potential energy, in order to formulate more perfect nursing intervention measures. Method Useing phenomenological method of qualitative research in selecting 6 dementia caregivers in-depth interviews to understand possible posttraumatic growth. Result Five major themes were found: changes in individual cognitive, changes in relations with others, promote their children′s education, reflections and concerns on status of pension-related changes in philosophy of life. Conclusions Dementia caregivers also have the positive performance of posttraumatic growth, in addition to the negative experience. Clinical nurses should actively explore the potential and power from the growth perspective. This is conducive to the caregivers with more health caring for life, so as to improve the quality of care, and ultimately improve the quality of life.

Objective To analyze the relationship between preoperative biochemical indexes and effect ofpostoperative first 131I internal irradiation for differentiated thyroid carcinoma. Methods One hundred and eighty patients of thyroid carcinoma within the first 131I internal irradiation postoperative. According to curative effect were divided into effective group (96 cases) and invalid group (84 cases) and their clinical data were retrospectively analyzed. Results The preoperative serum alkaline phosphatase (AKP) and thyroid-stimulating hormone (TSH) in effective group and invalid group were respectively (74.83 ± 19.77),(65.50 ± 11.84) U/L and (3.12 ±0.59), (2.57 ±0.56) mU/L. There were significant difference (t =3.77,6.39, P < 0.01) between two groups. Conclusion The levels of preoperative serum A KP and TSH are important factors to influence the effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma.

Objective In order to know the application effects of transcatheter hepatic artery chemoembolization for patients with liver cancer. Methods Divided 144 liver cancer patients into the experimental group and the control group randomly, there were 82 cases in each group. Routine nursing cares were used in the control group, humanized nursing were used in the experimental group in addition. Compared the curative effect, incidence rate of complication and scores of SAS and SDS between the two groups. Results The curative effect in the experimental group was significant better than in the control, the incidence rate of complications were lower in the experimental group than those of in the control group. Before out of hospital, the SAS and SDS level in the experimental group was better than in the control group. Conclusions Humanized nursing can enhance the curative effec4 avoid disputs between patients and nurses, and then promote nurses' working interesting.

Epstein-Barr virus infects widely, and has a powerful ability to transfrom into a number of malignant diseases. The infection is mostly latent, without any obvious clinical symptoms. At present, more and more researches have found that cell-mediated immunity,especially T lymphocyte response plays an important role in the control of Epstein-Barr virus infection.

Glutathione S-transferase kappa 1 (GSTK1) is a key regulator for adiponectin secretion and multimerization.In Caenorhabditis elegans,GSTK1 is involved in energy production and lipid metabolism.Meanwhile,the GSTK1 level is negatively correlated with obesity.It may alleviate the endoplasmic reticulum stress-mediated downregulation of adiponectin.Moreover,a polymorphism in human GSTK1 promoter is related with insulin secretion and fat deposition.Therefore,GSTK1 might be a novel target for the treatment of insulin resistance and the relevant metabolic diseases.

Hepatitis B virus (HBV) infection is a global public health issue,especially in the Asian-Pacific region.At present,entecavir,tenofovir,and pegylated interferon are the first-line antiviral drugs recommended by related guidelines for the prevention and treatment of hepatitis B;however,different national/regional policies,economic level,coverage of health insurance,and medical level have caused the difference in antiviral regimens.Therefore,we have established a long-term follow-up cohort of hepatitis B to evaluate the efficacy of different treatment regimens,in order to improve the cure rate of hepatitis B and reduce the incidence rates of liver cirrhosis,liver cancer,and end-stage liver disease.Real-world data from cohort study help to understand the differences between guidelines and clinical practice,provide a reference for HBV guidelines,and balance clinical effect and cost-effectiveness.