Ocular neovascularization is the primary cause of blindness in a wide range of ocular diseases.The common blinding diseases,including diabetic retinopathy,age-related macular degeneration,infectious keratitis,are all caused by neovascularization.Osteopontin (OPN) is a glycoprotein,which can promote angiogenesis and tissue repair.It is aboudantly expressed in corneal neovascularization,choroidal neovascularization and retinal neovascularization,and promotes angiogenesis.The relationship between OPN and ocular neovascularization provides a new direction in research and treatment of neovascular diseases.This paper reviewed the research progress of OPN and ocular neovascular diseases.

Metabotropic glutamate receptors (mGluRs) are a family of G protein coupled receptors linked to modulation of ion channel functions and multiple second messengers. These receptors are widely distributed throughout the basal ganglia (BG). Studies have demonstrated that these mGluRs subtypes located at various synapses in BG could modulate the release of dopamine and glutamate which correlates with brain area,the subtype selectivity and concentration of the ligands. Metab otropic glutamate receptors have been proposed as potentially new therapeutic targets for Parkinsons disease by providing a method of pharmacologically regulating neurotransmission in the BG.

This paper showed that levels of cAMP, PGE_2 in plasma and cAMP in spleen tissue and abdominal cavity macrophages in burned rats are increased (cAMP levels in plasma of the control groups were 24.65?4.59pmol/ml; PGE_2 levels were 309.38?77.64Pg/ml. cAMP levels in plasma of burned groups were 36.58?2.74pmol/ml: PGE_2 levels were 937.50+102.91Pg/ml; P

The purpose of this study was to investigate the effects of gypsum on LP-induced fever and the CSF levels of cAMP and cGMP in rabbits. It was found that gypsum could inhibit the rise of body temperature caused by LP injection, (△T of gypsum +LP group is 0.40?0.08℃, TRI_3 2.55; LP group 0.91?0.06℃, TRI_3 4.99 P

The compound of active ingredients of traditional Chinese medicine (TCM),whose material base is relatively clear,adheres to the concept and advantages of formula compatibility of TCM.Thus,it is an important approach to modern TCMresearch.The significance of research on compound of TCMcomponents/ingredients,as well as the research ideas,is sketched out,and the current research on compound of TCMcomponents for the prevention and treatment of liver diseases is reviewed.The research strategies for TCMcomposition/compound for the prevention and treatment of liver diseases are elucidated from the following two aspects:exploring the compound of TCM components based on clinical TCM compound and studying the composition aiming at the effective components or ingredients of TCM that have been known;it is pointed out that the compatibility of effective TCM components,which provides the method and technology system for innovative drug research,is an innovative research model for inheriting and developing the TCMtheory and is one of the important approaches to modern TCM research.

The effect of hydroxyprolpyl methylcelulose (HPMC) injected into anterior chamber on filtering angle tissues was studied. Twenty-four rabbits were randomly divided into two groups: the experimental group included 40 eyes receiving HPMC which was injected into anterior chamber and the control group included 8 eyes (one served as normal control and the remaining were injected with balanced salt solution). According to the intaocular pressure (IOP) was normal or elevated ,the experimental group was further divided into group A and B. The tissul specimen of filtering angle were collected to perform pathological examination at 5 days, 3 weeks ,and 10 weeks after injection.During the early period, in groupA,the trabecular meshwork dilated slightly, the vacuoles increased in endothelial cells of inner wall of Schlemm's canal. In group B, the space of trabeculum broadened, there were accumulation of collagen and intercellular fibrosis, the vacuoles significantly increased in endothelial cells of inner wall of Schlemm's canal. But the change mentioned above all recovered to normal appearance on the later stage of long term following observationHPMC injected into anterior chamber may cause temporary elevation of IOP and pathological change of filtering angle, but the change was reversible. HPMC is not toxic or destructive to the tissues of anterior chamb angle.

The treatment of myopic amblyopia and myopic anisometropic amblyopia is difficult and usually resultless and it has been the obstacle of amblyopic treatment. Corneal contact lens, corneal refractive surgery and phakic intraocular lens as new methods can significantly improve visual acuity of patients with high myopic amblopia and myopic anisometorpic ambyopia. For correcting myopia and myopic anisometropic amblyopia it provides a new method. This paper discusses the availibility and safty of above methods for the treatment of myopic amblyopia and myopic anisometropic amblyopia.

The purpose of this study was prospectively to research the relationship between EEG power spectrum and anesthesia depth. Twenty-four patients,aged 20 to 50 years , ASA grade ,scheduled for selected surgical operations, were randomly divided into two groups:enflurane and isoflurane groups. Anesthesia was induced by thiopental 5 mg/kg and atracurium 6-7 mg/kg intravenously and maintained by inhalation anesthetics. After intubation patients were ventilated mechanically to maintain the level of PETCO2 between 4. 27 and 4. 93 kpa. NIBP,HR,SpO2 , ECG and EEG were recorded during anesthesia. According to TOF stimulation test intravenous atracurium 10-15 mg was given intermittently to maintain the ratio of T4/T1 less than 25%. Two channels EEG monitor was applied with the filtration range from 0 to 30 Hz Anesthesia level, adjusted at 0. 5,0. 8, 1. 0, 1. 3, 1. 5, 1. 3, 1. 0, 0.8 or 0. 5 MAC in sequence ,was maintained for 10 to 15 minutes before SEF (spectral edge frequency)and MPF (median power frequency) were recorded. NIBP decreased and HR increased with the inhaled agent concentration (IAC) level rising. The lowest BPs were 13. 1 /9. 33 kPa and 12. 9/8. 1kpa in both groups. There were negative remarkable correlations between either SEF or MPF and IAC in both groups (=- 0. 94 and -0. 82,P

The effects of different concentrations of enflurane and enflurane/nitrous oxide on EEG in 20 patients (ASA grade Ⅰ) were studied during elective surgery. They were divided randomly into two groups:enflurane (E) group (n=10) and enflurane/nitrous oxide (EN) group (n= 10). Anesthesia was induced by inhaling enflurane or enflurane/60% nitrous oxide. After intubation patients were venti lated mechanically to maintain P_(ET)CO_2 4.27—4.93 kPa, Two-leads EEG monitor was used during operation. 95% spectral edge frequency (SEF),MAP and HR were recorded in group E at 0.5,0.8,1.0,1.3 and 1.5 MAC, and in group EN at 0.8,1, 0,1.3,1.5,1.8 and 2.0 MAC. SEF decreased in linear manner,but MAP insignificantly changed as enflurane level increased. SEF was smaller in group E than that in group EN under the same additive MAC value, In raw EEG,patients in group E had spike wave at more than Ⅰ.0 MAC,but there was no spike wave in group EN. So enflurane/nitrous oxide anesthesia is more proper because nitrous oxide diminishs the undesirable effects of enflurane on brain during deeper anesthesia. The simple additive MAC value may not reflect the exact anesthesia level when nitrous oxide is used in combination, but SRF can do it.

LOVO.PGZ significantly up-regulates the expression of PPAR? in MGC803 and LOVO cells,the expression of PPAR? was higher in combination group than PGZ alone(P