Objective:To observe effects of Cuttle-Bone on blood inorganic phosphorus and parathyroid hormone(PTH)in patients of uremia in hemodialysis.Methods:74 cases of uremia in hemodialysis were randomly divided into a control group,a cuttlefish bone treatment group and a calcium carbonate treatment group.The control group did not take any conjugation agent of phosphorus. The cuttlefish bone treatment group were treated with oral administration of cuttlefish bone powder 3.0g in each meal and the calcium carbonate treatment group with chewing calcium carbonate tablets 1.5g in each meal.They all were treated for 3 months. Results:After treatment,blood inorganic phosphorus and PTH decreased(P0.05),with less effect on blood calcium(P

Objective To investigate the relationship between the development of pancreatic cancer and inflammation, and the therapy strategy.Methods Related articles were reviewed.Results The pathogenesis of inflammation in pancreatic cancer development involves cytokines, NF ?B, COX 2, PPAR ?, DNA damage, gene changes,etc. Based on these mechanisms some medications are under developing.Conclusion Accumulative effects of pancreatic inflammation may lead to DNA changes, and even pancreatic cancer development. Medications aimed at suppressing pancreatic inflammation may help with prevention and treatment of pancreatic cancer.

Objective To observe the therapeutic effect of triclabendazole in patients with paragonimiasis skrjabini. Methods Four patients were treated with triclabendazole at dosage of 10 mg/kg bid for 3 days and were followed up for 6～10 months. The clinical symptoms, chest X ray, hemogram and liver function tests were observed before and after treatment. Results Migratory subcutaneous nodules in three patients all disappeared. Small amount of pleural effusion were absorbed in two patients. Severe headache subsided in a patient with cerebral lesion. MRI showed a bean sized calcified spot in the right frontal region. Chest X ray in 2 patients showed that pulmonary lesions were markedly absorbed and disappeared. There was no adverse effect of the drug.Conclusion Triclabendazole has marked therapeutic effect on paragonimiasis skrjabini. It is safe in administration and well tolerated.

Objective To explore the clinical effect of sodium hyaluronic acid on prevention of post-surgical pelvic and abdominal adhesion in gynecology.Methods 336 patients with pelvic and abdominal operation,using the double blind method for the patients and doctors,were randomly divided into the observation group (172 cases)and control group(164 cases).The experimental group was given hyaluronic acid in corresponding regions of the peritoneum,and the control group was not given any tissue adhesion prevention measures.Postoperative adhesions incidence and the change of serum CRP level of two groups were recorded.Results There was significant difference between the two groups in postoperative adhesions incidence (47.5％ vs 19.8％,x2 =13.10,P ＜ 0.01).The CRP level of the observation group changed significantly as compared with the control group after operation [(24.5 ±3.4)mg/L vs(12.7 ±3.9)mg/L(t =20.86,P＜0.01)].Conclusion Hyaluronic acid in prevention of postoperative adhesion of pelvic and abdominal operation is effective on improving the serum level of inflammatory factors.

Objective To study the protective effect and mechanism of SD rats′liver transplantation reperfusion ischemia‐reper‐fusion injury(IRI) after GW3965 activation of liver X receptor preprocessing .Methods Separated Male SD(Sprague‐Dawley) 70 rats into 3 groups which were sham operation group (SO group ,14 rats) ,orthotopic liver transplantation group (OLT group ,28 rats) ,and GW 3965 preprocessing group(GW 3965 group 28rats) .The levels of serum transaminase ,plasma inflammatory factors (TNF‐α、IL‐1) ,the changes of hepatic pathology and inflammatory factor mRNA ,and the activities as well as its expressions of NF‐κB in hepatic tissue were observed ,after the operation .Results After 6 and 24 hours perfusion ,the levels of plasma inflammatory factors was expression ,serum transaminase ,the liver pathological injury degree and the activities as well as its expressions of NF‐κB in OLT group and GW3965 group were higher than those in SO group .While after reperfusion for 6 and 24 hours ,the levels of ser‐um transaminase ,plasma inflammatory factors expression ,the liver pathological injury degree ,inflammatory factor and the activities as well as its expressions of NF‐κB in GW3965 group were much lower than those in OLT group ,there were obvious differences (P<0 .05) .Conclusion After GW3965 activation of liver X receptor preprocessing ,the activities of NF‐κB and the emerging of downstream inflammatory mediator factors are reduced effectively and protect the liver after the ischemia reperfusion .

Objective To investigate the clinical value of minimally invasive rotary resection in the treatment of mastitis with abscess formation. Methods A total of 93 cases with mastitis with abscess formation in our hospital from October 2010 to December 2014 were divided into two groups according to patients ’ willingness: one group was given ultrasound-guided Mammotome rotary surgery and drainage (minimally invasive group, n=45), the other underwent incision and drainage (control group, n=48).Surgical parameters, postoperative complications and patient satisfaction were compared between the two groups. Results The minimally invasive group was significantly superior to the control group in the operative time, blood loss, healing time, postoperative scar length and postoperative complications [(16.0 ±4.4) min vs.(30.6 ±6.8) min, t=-12.339, P=0.000;(8.5 ±2.3) ml vs.(12.7 ± 4.1) ml, t=-6.102, P=0.000;(10.1 ±1.9) d vs.(14.3 ±3.3) d, t=-7.595, P=0.000;(4.6 ±1.2) mm vs.(40.5 ± 11.8) mm, t=-20.913, P=0.000;8.9%(4/45) vs.25.0% (12/48), χ2 =4.232, P=0.040].Follow-up reviews at 3-6 postoperative months showed the comprehensive satisfaction of operation was significantly higher in the minimally invasive group (37/45, 82.2%) than that of control group (28/48, 58.3%) (χ2 =6.299, P=0.012). Conclusion For mastitis with abscess formation, minimally invasive rotary surgery has characteristics of minimal invasion, quick postoperative recovery, good cosmetic effects, few complications and high patients’ postoperative satisfaction.It deserves further clinical application.

Objective To investigate the protective effect of astragaloside on cardiomyocyte mitochoddria and inhibition effect on cardiomyocytes apoptosis of the rats with heart failure, and explore the treatment mechanism. Methods Sixty SD rats were randomly divided into control group, model group, astragaloside group, and trimetazidine group. The last three groups were injected subcutaneously with isoproterenol to make the heart failure model. Astragaloside group was given astragaloside 50 mg/(kg?d), and trimetazidine group was given trimetazidine 10 mg/(kg?d) orally for three consecutive weeks. At the end of the experiment, the myocardial tissue specimens of each group were made, inverted fluorescence microscope was utilized for measuring mitochondrial membrane potential (MMP), immunoblotting was utilized for detecting cardiomyocyte telomerase reverse transcriptase (TERT) expression, and flow cytometry was untilized for detecting cardiomyocyte apoptosis. Results The MMP ratio of astragaloside group was 3.226±0.371, significantly higher than the model group and trimetazidine group (P<0.01). The cardiomyocyte apoptosis rate of astragaloside group was 8.91±2.12, significantly lower than the model group and trimetazidine group (P<0.01), and the most obvious expression of TERT was found in astragaloside group. Conclusion Astragaloside can protect damaged mitochondria, promote TERT expression, inhibit cardiomyocyte apoptosis and protect cardiomyocytes.

Objective To summarize the key point of collaboration during the surgery of endoscopic guided vitrectomy for complicated ocular trauma.Methods From October 2010 to March 2013,a total of 25 cases(25 eyes) of complicated ocular trauma were treated by endoscopic guided vitrectomy.The the key point of collaboration was summarized.Results Surgeries of 25 cases (25 eyes) went smoothly,visual acuity improved,without enucleation cases.Postoperative complications were mainly secondary glaucoma and vitreous hemorrhage,and all were improved after treatment.Conclusions Endoscopic guided vitrectomy for the treatment of complicated ocular trauma is one of the effective means,and the advantage is that the surgery could be done when the refractive medium is opacity.

Hepatocellular carcinoma (HCC) is one of the most common cancers in the worldwide.In recent years,the development of imaging techniques has facilitated the detection of HCC at early stages.However,HCC has a high frequency of portal vein invasion,which is reportedly observed in 11％ to 42％ of patients with HCC.Portal vein tumor thrombus(PVTT) is a crucial factor that can worsen the prognosis of HCC because it can be wide dissemination of tumor throughout the liver and cause a marked deterioration of hepatic function.It was considered that is not appropriate with surgical treatment in the past,which is treatment conservative or even give up,most of the patients died within a few months.Even if the patients have a chance to surgical resection,and the most of patients combined with TACE,portal vein stent implantation or chemotherapy postoperative,some patients can be more prolonged survival,however,due to the small tumor thrombus and micro metastases have exist before the surgery and can not be checked out.it's difficult to clean up in the surgery,easily lead to HCC recurrence postoperative.However,with the constant awareness the PVTT formation mechanism and scientific technology progress,more and more new treatment techniques is applied to clinical.This view focuses on the portal vein tumor thrombus formation mechanisms and Classic Transcatheter Arterial Chemoembolization and new treatment methods such as:Helical tomotherapy,CIK cell therapy (cytokine-induced killer cell therapy),Chemoembolization and stent combined with iodine-125 seed.