The serum suppressive activity on PHA-induced lymphocyte transformation of healthy individuals was evaluated in 76 serum samples from 55 patients with systemic lupus erythematousus(SLE).The serum suppressive activity seemed well correlated with the activity of SLE. The highest levels of suppressive rate (55.02+29.62％) and positive rate(88.33％)were found in patients with active disease. Once disease improved, both suppressive rate and positive rate were reduced (22.17?51.28％ and 51.85％ respectively), when the patients entered into stationary stage, the serum suppressive activity were not observed. The correlation between suppressive activity and lymphocyte transformation test, E-rosett inhibition factor, the levels of serum CIC, IgG, IgA, IgM. C3 and ANA titers were analysed. Stepwise discriminant analysis indicated that the serum suppressive activity was more closely related to disease activity than other immunological indexes. The nature of suppressive factor was discussed.

Objective To observe the efficacy of comprehensive strategies in treating diabetic foot.Methods Thirty five cases with diabetic foot were treated by comprehensive strategies,including antiinfection,strict blood sugar control,vasodilatation,improvement of microcirculation,never nutrition,debridement and supportive care,etc.Results Among the 35 patients with diabetic foot,24 were recovered satisfactorily,7 cases were recovered with improvement,2 cases underwent amputation and 2 cases gave up further treatment.Conclusion Diabetic foot can be treated by comprehensive measures satisfactorily,with improved cure rate and low amputation rate.

Background and purpose:Concurrent chemoradiotherapy followed by adjuvant chemotherapy have been administrated to locally advance nasopharyngeal carcinoma according to the NCCN guidelines.This study s pecifically evaluated the efficacy,toxicity and compliance of modified concurrent chemoradiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma(NPC).Methods:From Nov.2003 to Apr. 2005,67 patients with stageⅢandⅣlocally advanced nasopharyngeal carcinoma(NPC)were enrolled in this study.A total dosage of radiation,70-74 Gy,was given in 35-37 fractions in 5 fractions per week.Two cycles of chemotherapy, consisting of cisplatin 25 mg/m2?d-1 and 5-fluorouracil 300 mg/m2?d-1 were delivered simultaneously with radiotherapy on the day 1-3 during week 1 and 5.Three cycles of adjuvant chemotherapy,consisting of cisplatin 25 mg/m2?d-1 and fluorouracil 450 mg/m2?d-1,were also given,starting on day 1-3 during week 10,13 and 16.Results:The median follow-up was 20 months(ranged from 11 to 27 months).The 2-year overall survival rate and the 2-year diseasefree survival rate were 91.75%and 81.56%respectively.The 2-year overall survival rate was 96%for stageⅢand 87.65%for stageⅣ(P=0.334).The 2-year disease-free survival rate was 92.16%for stageⅢand 69.35%for stageⅣ respectively(P=0.2358).The compliance rates were 100%for radiotherapy,47 cases(70.1%)for all chemotherapy, 56 cases(83.6%)for concurrent chemotherapy and 48 cases(71.6%)for adjuvant chemotherapy.The main grade Ⅲ/Ⅳacute toxicity events during concurrent chemoradiotherapy were neutropenia in 15 patients(21.4%),vomitting and nausea in 2 patients(3%),mucositis in 56 patients(83.6%),and gradeⅢskin reaction in 10(15%),respectively. The main gradeⅢ/Ⅳacute toxicity events during adjuvant chemotherapy were neutropenia in 13 patients(19.4%), grade 3 anemia in 2 patients(1.5%)respectively.Conclusion:The primary result showed a good compliance,lower incidences of toxicity and improved early outcome of treatments for the patients with stageⅢand stageⅣ(M0)NPC. The ultimate therapeutic ratio will be updated according to longer follow-ups.

Lung cancer is the leading cause of morbidity and mortality of malignant tumor.Surgery,radiotherapy and chemotherapy remain the primary means of treatment for lung cancer,while the discoveries of molecular targets and targeted agents for lung cancer are making revolutionary changes and will almost certainly propel progress in this field into the foreseeable future.Biomarker-based individualized comprehensive treatment strategy is expected to benefit the lung cancer patients' survival.Meanwhile,chemotherapy remains the major treatment of advanced non-small cell lung cancer,which requires implementing the "three combinations" dialectical therapy principles,that is,systemic with local,conventional with personalized,eliminating with supporting.

Objective: To compare the ocular parameters of acute angle closure glaucoma (AACG) and chronic angle closure glaucoma (CACG). Methods: Totally 106 patients with primary angle closure glaucoma were recruited: 58 patients with AACG and 48 with CACG. All patients were divided into 3 groups: AACG attack eyes group, AACG uninvolved fellow eyes group and CACG group and underwent the same ophthalmic examinations, comprising optometry, keratometry, and A-scan ultrasonography. The lens/axial length factor (LAF) and relative lens position (RLP) were calculated. Results: The AACG attack eyes had a significant shallow anterior chamber depth, thick lens, short axial length and larger LAF. hTere tended to be a reduction in the percentage of LAF>0.20 in AACG attack eyes, CACG eyes and AACG uninvolved fellow eyes, though there were no statistically signiifcant difference in all groups (P>0.05). Conclusion: The eyes with AACG attack have a more crowded anterior chamber structure compared with uninvolved fellow eyes and eyes with CACG.

The paper analyzes the status of hospital websites construction in Jiangau province, which would provide useful evidence for further development. Surfing on the hospital wehaites covering both third and second class hospital in Jiangsu province, it reveals that the websites of third-class hospital are much better than the second-class ones. However, both of them have problems on contents, domain names and interactive parts. The paper suggests that we should constantly explore the methods and ways to solve those existing prob-lems, focus on strengthening informafization construction in hospital and play its advantages.

Recent studies about stem cells show that the formation of portal vein tumor thrombus(PVTT)is closely relative to the metastasis of liver cancer stem cells induced by portal vein microenvironment.Liver cancer stem cells first detach from the primary tumor,extravasate to extracellular matrix,stimulate angiogenesis or intravasate and migrate through the systemic circulation,evade host defense mechanisms,migrate to specific blood vessel sites through chemo-taxis and attach to blood vessel wall,then extravasate through blood vessel and home to specific microenvironment and to form PVTT.

Brachytherapy has become an important treatment for soft tissue sarcoma by its unique radio-biology and radiation physics characteristics, the treatment time is divided in accordance with preoperative brachytherapy, intraoperative brachytherapy, postoperative brachytherapy, brachytherapy alone, which in im-proving the rate of limb preservation and local control rate sarcoma has played an important role. However, the timing of treatment, treatment modalities, the choice of implantation dose is still in dispute.

Osteoporosis is a disease that threatens human health seriously.Orthopedics plays a very important role in the prevention and treatment of osteoporosis.Teachers of orthopedic department should pay more attention to the teaching of osteoporosis and establish specialized courses to make medical students to learn more about osteoporosis in clinical teaching process

[Objective]To propose new strategies on enhancing effectiveness of accidental damage and pioneer new realms for disease prevention strategy, this paper emphasized on analyzing the way and function of disease prevention strategy in therapeutic process of accidental damage.[Method]Literature review was applied to summarize and discuss the effect of some approaches guided by disease prevention strategy, including relieving the emotional tension and none-drug treatment.[Result]Three psychological defense lines were constructed during the therapeutic process which were under the guidance of disease prevention strategy, resulting in contribution to improve cognitive evaluation of patients, improve mood and relieve stress disorder. [Conclusion]Disease prevention strategy plays an important role in the psychosomatic recovery of injured students.