Patients with chronic renal failure (CRF) are often complicated by a variety of central nervous system and peripheral neuropathy, which are complex, varied, and with serious complications of kidney failure at the end stage. In recent years, due to the blood dialysis method, organ transplantation and other methods, some neurological compli-cations associated with these treatments. Therefore, analysis and identification of complications in CRF patients are of great significance and can improve the survival rate. Common complications were analyzed and evaluated in this pa-per, for which can provide the basis for improvement of the diagnosis and treatment for renal failure.

Objective To observe the clinical effect of atorvastatin in the treatment of acute cerebral infarction and observe the clinical impact of blood rheology. Methods 120 cases of patients with acute cerebral infarction were randomly divided into 60 cases of treatment group and 60 cases of control group. The control group got conventional treatment (compound Danshen injection, Edaravone Ozagrel injection and intravenous drip injection Note, oral enteric - coated aspirin tablets, etc. ). The pationts in treatment group were given atorvastatin calcium based on the conventional treatment. Patients in the two groups were treated for 3 months. The clinical efficacy and blood rheology indicators were observed. Results The total effective rate of the treatment group was significantly higher than that of the control group ( P

Four compounds have been isolated from Sargassum fusiforme(HaTv. ) Setch. collected in the south Zhejiang province of China. Among these compounds the structures of three have been deduced as mannitol, fucosterol and saringosterol on the basis of chemical and IR,NMR,MS spectral data.

Objective To analysis the serum levels of the Th1/Th2 cytokines interleukine-2 and interleukine-5 in patients with autoimmune thyroid disease(AITD) and investigate the relationship between the imbalance of Th1/Th2 cytokines and the pathogenesis of AITD.Methods 20 healthy as controls and 75 patients were studied.45 patients suffered from GD,30 patients suffered from HT.The serum concentrations of interleukine-2(IL-2) and interleukin-5(IL-5),representative cytokines of Th1 and Th2 cells respectively,were assayed by enzyme-linked immunosorbent assay(ELISA).Results(1)Compared with HT group and controls,the concentration of IL-5 in GD group was remarkably increased(P

The organic acidemia/aciduria is one of the most common inherited metabolic disorders in clinic,more than 50 species have been found until now.The illness is believed to be caused by gene mutation,leading to the reduction or loss of enzyme activity and the accumulation of carboxylic acid and its metabolites.The manifestations of increased blood organic acids include refractory metabolic acidosis,paroxysmal vomiting,feeding difficulties,hypotonia,convulsions and disturbance of consciousness.Most of the organic acidemia begins in neonatal period or infancy,accompanied by progressive neurological damages at most of the time.There are little specific clinical features can be found in this kind of diseases,therefore,early diagnosis and treatment must be initiated in order to decrease risk of neurological induries and damages or acute deaths.So application of the gas chromatography-mass spectrometry and tandem mass spectrometry is important to the early diagnosis,helpful for improving the outcomes and reducing child mortality.

Urea cycle disorder is a common inherited metabolic disorder,and it is the most common genetic cause of hyperammoniema in children.The illness is believed to be caused by gene mutation of six main enzymes in urea cycle,leading to ammonia,which is produced by amino acid catabolism,can't conver to urea through the urea cycle and be discharged through the urine.The manifestations of hyperammonemia turn out to be disorders of brain function (refusing to milk,vomiting,drowsiness,coma,convulsions,ataxia,aggressive behaviors).The incidence of this disease is 1/30 000.At the same time,the severity of the clinical symptoms is connected with the extent of the enzymes defects.More serious the enzymes defected,the earlier and worse the disease onsets.Some children with mild enzyme defects may intermittently attack or have a delay onset.Serious nervous system injuries can be found in hyperammonernia,therefore,early diagnosis and treatment must be ensured in order to decrease risk of mental injuries and damages or acute deaths.

Objective To investigate the correlation of homoeysteine (Hcy) and blood glucose level with type 2 diabetic fundus lesions.Methods Sixty patients with type 2 diabetic fundus lesions were selected and grouped as the diabetic fundus lesions group from February of 2011 to October of 2012,and 40 patients with type 2 diabetes were recruited as the diabetes group,40 healthy volunteer were recruited as the control group.Glycosylated hemoglobin Alc(HbAlc),fasting blood glucose(FBG),homocysteine(Hcy) and total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of the three groupwere measured and compared.Results Compared with the control group,Hcy in the diabetic fundus lesions group and the diabetic group were significantly higher than the control group ((17.6 ± 4.7) μmol/L,(13.3 ± 2.9) μmol/L vs.(7.3 ± 1.8) μmol/L),and as well as HbA1 c ((11.3 ±2.7)％,(9.2±1.4)％ vs.(4.0±1.1)％),FBG ((11.5 ±3.4) μmol/L,(10.1 ±2.1) μmol/Lvs.(4.2 ±1.7) μmol/L)and TC((6.7 ±1.1) mmol/L,(5.1 ±1.0) mmol/L vs.(4.4±0.8) mmol/L) (F=5.091,5.107,6.017,5.813,P =0.043,0.036,0.032,0.040 respectively).The Hcy,TC,TG,FBG and HbAlc of type 2 diabetic fundus lesions with I stage were the lowest,and the stage of type 2 diabetic fundus lesions was relevant with the level of Hcy,TC,TG,FBG and HbAlc,which were different significantly (F =5.418,5.524,4.971,5.713 respectively,P =0.038,0.041,0.042,0.040 respectively).Conclusion The serum Hcy and blood glucose are risk factors to type 2 diabetic nephropathy.Lowering Hcy concentration and reducing the glucose may be a new way to prevent the occurrence of type 2 diabetic nephropathy.

Oncolytic adenovirus is known to carry out the transformation of adenovirus,which has kill-ing role on tumor defective gene phenotypes,and Can be used as vector for tumor targeted tbempy drugs.At pres-ent,H101 and dl1520 and other biological products are gained from adenovirus type 5-specific gene fragments,which targeted tumor cell defects in the p53 gene expression,can specifically recognize tumor cells and Carry out proliferation and lysis of tumor cells.These biological products can be used as vectors to carry the anti-tumor genes and result in more powerful anti-tumor effects.

Objective To determine whether pancreatic ductal preservation(pancreatic ductal injection of sparing TIUW solution at the time of pancreas procurement)can improve islet yield and function after cold preservation of pancreas.Methods Pancreases were classified into five groups:fresh pancreases(group1 ,n= 10);preserved for 6 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group2, n=10 and group3, n = 10);preserved for 24 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group4 ,n= 10 and group5,n= 10).Dithizon(DTZ)staining was used to identify islet morphous and yield, trypan blue uptake(TBU)was used to assess the nonviability of islets, the insulin secretory response to glucose was used to evaluate islet function in vitro, islet transplantation was used to determine islet function in vivo.Results Islet yields per pancreas after purification in group 1 to 5 were 590± 127, 272 ± 50,454 ± 65, 253± 56, 447 ± 66(islet equivalent ± SD), respectively.Percentage of nonviable islets in grouplto5were(5.7±4.2)%,(18.3±6.5)%,(11.7±4.2)%,(26.3±5.6)%,(15.0±5.3)%.Stimulation index in group 1 to 5 were 7.32±2.32, 4.81±1.17, 7.56±2.44, 2.88±1.00, 5.71±1.90.Cure rates in group 1 to 5 were 100%, 0%, 100%, 0%, 70%.In this study, the differences were significant between control groups and experimental groups(P＜0.05, group 2 vs.group3 and group4 vs.group5).Conclusion The pancreatic ductal preservation can improve islet yield and function.

Objective: To investigate the risk factors of deep vein thrombosis after stroke. Methods: A retrospective analysis was made on the 420 cases patients with stroke in our hospital, according to the situation thrombosis were divided into thrombosis group and non-thrombosis group, compared two groups of patients with general information, and many factors with the significant indexes were retrospectively analyzed. Results: Age≥70 years old, bedridden, Wells score≥2 points lower limb NHSS score≥3, anticoagulant therapy, higher admission D-2 dimer, lower BI score and non-rehabilitation therapy were independent risk factor for stroke in patients with acute DVT. Age≥70 years old, bedridden, leg NHSS score≥3 points, the acute stage of DVT and BI score were the independent risk factor for stroke patients follow-up period of DVT. Conclusion:There are many related risk factors for stroke in patients with deep vein thrombosis, these factors should be used to carry out monitoring and preventing deep vein thrombosis, active rehabilitation and anticoagulant therapy should be taken to improve the prognosis of patients with stroke.