Cardiovascular disease(CVD) is a common fingding in paitients with chronic renal failure(CRF),its pathogenesis is not clear.In the past decade,the relation reduce of EPO,malnutrition and inflammation,endothelial dysfunctin and angiodysplasia with pathogenesis of CVD had been investigated,These risk factors inducing CVD were reviewed.

The role of the microvascular disease in progressive renal disease is not well understood .This review presents evidence that progressive renal disease is characterized by a progressive lose of the microvasulature. And presents the factors that induce the lose of the microvasculature. Try to find out (agents) which may represent a novel therpeatic approach for slowing the renal disease.

There are a number of serum biomarkers related with the process of the pathogenesis,destabilization and rupture of the atherosclerotic plaque.And thus,it is fairly important in clinical practice to identify vulnerable plaque and predict plaque rupture by detecting the expression of the serum biomarkers.This review aims at giving an overview on recent emerging biomarkers that are related to vulnerable plaque.

Nerve growth factor, a kind of neurotrophic factor, plays an important role in neuronal development, differentiation, survival and neurogenesis, and is considered as a link between neuroendocrine system and immune system in asthma attack. The possible mechanism of effects of nerve growth factor on asthma is as follows: (1) nerve growth factor changes airway innervation, and facilitates the synthesis and release of neurotransmitter in nerve terminal, which will contribute to airway remodeling; (2) nerve growth factor induces eosinophils aggregation, proliferation and releasing inflammatory factor, which will lead to the abnormality of immunologic response; (3) nerve growth factor triggers the redundancy of adrenal medullary cells, which results in adrenal medullary cell to nerve cell transition, and then the impairment of chromaffin cell endocrine secretion function. As a result, the concentrations of adrenaline in circulation are not competent to relieve the bronchoconstriction in asthmatic attack.

Dermcidin (DCD) was found in isolated human skin sweat glands with antimicrobial effect, and was defined as a kind of new small molecule antimicrobial peptide. It was a part of human sweat glands in the skin as the immune system's innate defense. With the studies of DCD, its extensive biological functions are gradually discovered. Since 2010, a number of studies have shown that DCD may be a new risk factor for atherosclerosis. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis and hypertension, platelet aggregation and acute myocardial infarction (AMI). In those experiments, it was also confirmed that aspirin had antagonistic and reverse effects on various biological functions of DCD. Further research on the role of DCD in cardiovascular and cerebrovascular diseases may lead to the prevention, early warning, prognosis evaluation and treatment breakthrough of cardiovascular and cerebrovascular events.

Objective To evaluate the curative effect of dydrogesterone and luteosterone in the treatment of threatened abortion.Methods PubMed,Chinese CNKI,Wanfang database were searched by computer.The randomized controlled trials (RCT) of dydrogesterone and luteosterone in the treatment of threatened abortion(RCT) were collected.Retrieval time was January 2011-March 2016.According to the inclusion and exclusion criteria,the two reviewers independently screened the literature,extracted data and evaluated the quality of themethod,the Rev Man 5.3 software was used for Meta analysis.Results In the final 8 RCT,a total of 1 438 patients were selected.Meta analysis showed:676 cases of 719 patients had clinically effective in the dydrogesterone group,and 605 cases of 719 patients had clinically effective in the luteosterone group(OR =2.94,95％ CI =2.04 ～ 4.24).The clinical effect of the dydrogesterone group was significantly higher than that of the luteosterone group(P ＜ 0.01).The funnel plot was basically symmetrical,and the publication bias was small.The occurrence incidence rate of adverse reactions of the dydrogesterone group was lower than that of the luteosterone group (OR =0.57,95％ CI =0.36 ～ 0.89,P =0.01).The backache relief time of the dydrogesterone group was significantly lower than that of the luteosterone group(MD =-4.96,95％CI =-5.18 ～-4.73,P ＜ 0.01).The relief time of abdominal pain of the dydrogesterone group was significantly lower than that of the luteosterone group (M D =-0.85,95 ％ CI =-1.23 ～-0.46,P ＜ 0.01).The hemostasis time of the dydrogesterone group was significantly lower than that of the luteosterone group (MD =-2.87,95％ CI =-3.52 ～-2.22,P ＜ 0.01).Conclusion Compared with the oral luteosterone,dydrogesterone in the treatment of threatened abortion has higher effective rate,less adverse reactions,and the relief time of backache and abdominal pain,hemostasis time is shorter,so dydrogesterone for threatened abortion is obviously better than luteosterone capsules,and it is worthy of clinical reference.

Objective To analyze and discuss the clinical effect of montelukast in the treatment of children with mycoplasma pneumoniae infection.Methods 21 7 children with mycoplasma pneumoniae infection were collect-ed,98 cases of airway height response after infection were selected as the research subjects in this observation,who were randomly divided into control group and observation group,among them 49 patients in the control group received conventional treatment,while 49 cases in the observation group added montelukast treatment based on the control group.The clinical effect and the occurrence of adverse reaction after 1 week of treatment were compared,at the same time,compared and discussed irritating cough onset,continue time,decrease time of cough and treatment time in the two groups.Results There were no adverse reactions in the two groups of children after treatment,98 cases were all cured,which suggested that the test was a complete success.The clinical efficacy of the control group after 1 week was 71 .43%,which was 97.96% in the observation group;In the control group,the duration of the stimulus onset,dura-tion,duration of treatment,treatment time and time of treatment were (5.20 ±2.64)d,(1 2.50 ±3.82)d,(1 3.1 0 ± 4.1 5)d,(20.80 ±1 0.65)d,which of the observation group were (4.1 0 ±0.27)d,(7.40 ±2.43)d,(8.90 ± 0.36)d,(1 6.40 ±8.32)d,the differences were statistically significant (t =2.901 ,7.885,7.057,2.279,all P <0.05).Conclusion Montelukast can promote and consolidate the curative effect in the treatment of airway hyper responsiveness in children with mycoplasma pneumoniae infection,it is recommended to promote in clinical because it has no serious side effects.

Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary of in vitro selection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery.

BACKGROUND:The essence of cell differentiation is a selectively intra-cellular gene expression,which results in specific proteinic synthesis and causes changes in biochemistry,structure and function.Thus,original proteomics and a single protein analysis can not meet the requirement in study.Proteomics technology provides a powerful tool due to the large scale,systemical study of protein transformation and interaction,which can be used for exploring molecular mechanism of bone mesenchymal stem cells(BMSCs)during directional differentiation.OBJECTIVE:To introduce proteomics,to summarize the research of proteomics in directional differentiation of BMSCs,and to forecast the development of proteomics research methods.METHODS:To search articles highly related with BMSCs,cell differentiation,and proteomics published on CNKI (www.cnki.net/index.htm),Sciencedirect(http://www.Sciencedirect.com),I.S.I(http://www.isiwebofknowledge.com)were searched,and the key achievements were included in the analysis.RESULTS AND CONCLUSION:A total of 29 documents were reviewed,and the experiences in the application of proteomics technology in the directional differentiation of BMSCs were summarized.With the innovation and development in methodology and technology,proteomics will become a powerful tool for us to study the potential mechanisms of BMSCs directional differentiation.

As the subject of educational scientific research work,teachers are the first driving force of curriculum reform and specialty building in school.The deployment and quality of teachers are closely related to scientific research achievement.In order to ascertain their relationship the situation of articles published papers and scientific projects have been analysed combined with the age professional titles and educational background of teachers in our college,which may provide preferences for the sustainable development of the school.