BACKGROUND AND OBJECTIVES: Tumor angiogenesis is an essential process required for growth and metastasis of cancer. Basic fibroblast growth factor (bFGF) is one of angiogenetic factors, and platelet endothelial cell adhesion molecule (CD-31) is the commonly used marker to identify the vessel. It is unclear that the degree of angiogenesis and expression of bFGF are related to the growth and metastasis in laryngeal squamous cell carcinoma. We examined the expression of bFGF and degree of angiogenesis in laryngeal squamous cell carcinoma and compared them to normal larynx. Relationship between bFGF and angiogenesis to growth and nodal metastasis in laryngeal squamous cell carcinoma was also evaluated. MATERIAL AND METHODS: Immunohistochemical study for bFGF and CD-31 were performed to detect the angiogenetic factor and degree of angiogenesis in 24 squamous cell carcinoma of larynx and 6 normal laryngeal tissue. Relationship of bFGF expression and degree of angiogenesis in laryngeal squamous cell carcinoma were compared to that in normal larynx. We evaluated relationship of expression of bFGF and degree of angiogenesis to primary stage and nodal stage in laryngeal squamous cell carcinoma. RESULTS: These expression of bFGF and degree of angiogenesis in laryngeal squamous cell carcinoma were significantly higher than in the normal control (p<0.05). The degree of angiogensis were significantly correlated with bFGF expression (p<0.05): the bFGF expression and degree of angiogenesis were not correlated to the nodal stage, but to the primary stage in laryngeal squamous cell carcinoma (p<0.05). CONCLUSION: These results indicate that bFGF and angiogenesis may play an important role in the growth of larygeal squamous cell carcinoma.
Blood Platelets ; Carcinoma, Squamous Cell* ; Endothelial Cells ; Fibroblast Growth Factor 2 ; Larynx ; Neoplasm Metastasis

BACKGROUND: Mucosa-associated lymphoid tissue(MALT) lymphoma has an indolent natural course. However, extra-gastric MALT lymphoma has been reported to have more frequent relapses and shorter time to progress than gastric MALT lymphoma. We performed this study to analyze clinical features of extra-gastric MALT lymphoma. METHODS: We retrospectively reviewed the medical records of the patients who were diagnosed as extra-gastric MALT lymphoma at the Samsung Medical Center from March 1995 to January 1999. The survival was analyzed by Kaplan-Meier method. RESULTS: During the study period, extra-gastric MALT lymphoma was diagnosed in 50 patients. The median age was 51(28-87)yaers. The male to female ratio was 22:28. Commonly involved sites were conjunctiva (25/50, 50%), lung (6/50, 12%) and intestine(6/50, 12%). Histopathologically, low to high grade ratio of extra-gastric MALT lymphoma was 47:3. Among 41 patients who were staged, 32 patients(78%) had stage I or II and 9 patients(22%)had stage IV. B symptoms were seen in only 3 patients. Bone marrow involvement was observed in 4 patients. The duration of median follow up was 22 months. The 1-year and 2-year survival rates were 95.1% and 91.4% retrospectively. CONCLUSION: Majoity of our cases with extra-gastric MALT lymphoma had low grade, early stage, good treatement reponse and good prognosis.
Bone Marrow ; Conjunctiva ; Female ; Follow-Up Studies ; Humans ; Lung ; Lymphoma ; Lymphoma, B-Cell, Marginal Zone* ; Male ; Medical Records ; Prognosis ; Recurrence ; Retrospective Studies ; Survival Rate