1.A case report of intracranial infection caused by Aggregatibacter aphrophilus
Siyu YU ; Yuhua SUN ; Yabo WANG ; Xin JIANG ; Xiangshu CHENG ; Houting ZHENG ; Chen LI ; Yalin LIU
Chinese Journal of Neurology 2022;55(5):506-510
Aggregatibacter aphrophilus is a member of the normal flora of the human oral cavity and pharynx, a Gram-negative fastidous bacteria, belonging to agglomerates, which is a normal mixed oropharyngeal flora in humans, most commonly colonized on the surface of oral mucosa. This bacterial infection is rare in clinical practice, and it is difficult to culture and identify the bacteria, which is easy to be missed. A patient with intracranial infection was admitted to Huaihe Hospital, who showed fever and headache as the main clinical manifestations, and Aggregatibacter aphrophilus was detected by the metagenomic next-generation sequencing of cerebrospinal fluid. The patient′s symptoms were significantly improved after anti-infection treatment.
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