1.STUDIES ON THE CHEMICAL CONSTITUENTS FROM THE SOUTH CHINA SEA HARD CORALPAVONA FRONDIFERA
Songzhi DENG ; Fengying LI ; Houming WU
Chinese Journal of Marine Drugs 1994;0(04):-
Two compounds were isolated from the hard coral Pavona frondifera Lamarck collected from the South China Sea by chromatographied on gel colum and recrystallization. Their structures were determined by UV,IR,MS,1HNMR and 13CNMR data. It first reported about the chemical compounds of the hard coral Pavona frondifera Lamarck.
2.The relationship of CYP2C19 gene polymorphism with clopidogrel responsiveness and the level of EETs in patients with acute coronary syndrome
Houming LI ; Yanxian FENG ; Yuli HUANG ; Miaonan LI ; Hongju WANG
The Journal of Practical Medicine 2017;33(6):912-916
Objective To assess the relationship of CYP2C19 gene polymorphism with clopidogrel respon-siveness and the level of EETs in patients with ACS. Methods A total of 123 patients with ACS receiving aspirin combined with clopidogrel dual antiplatelet were enrolled. According to the results of CYP2C19 genotype,patients were divided into three groups:fast metabolic type ,medium metabolic type ,and slow metabolism type. The concentration of EETs and PAIR were compared between three groups. Logistic analysis was used to analyze the risk factors of LCR. Results There were differences statistically in level of EETs and PAIR among the three groups(P<0.05). Logistic analysis showed that the slow metabolism of CYP2C19 gene and lower EETs level were risk factors for LCR. The area under the ROC curve was 0.893(P < 0.05)by EETs level to predict the CYP2C19 genotype. Conclusion The slow metabolism of CYP2C19 gene was an independent risk factor for LCR,while the increase of plasma EETs level was a protective factor.
3.Management of key diseases at emergency department of general hospitals
Yang LI ; Qing SHAN ; Kejie MA ; Houming QIAN
Chinese Journal of Hospital Administration 2014;30(11):832-834
This paper analyzed the main problems confronting support-type emergency management in general hospitals,introduced the experience and effect to strengthen the management of emergency key diseases in the hospital.The efficiency and success can be improved by implementation of institutionalized and routing management,emergency plan management based on the key diseases and strengthening the information construction and management.
4.Research progress in mitochondrial quality control in schizophrenia
Haoran CHU ; Cuicui CUI ; Xianbiao SU ; Hongchang ZHANG ; Jiashu MA ; Houming ZHU ; Ludong BAI ; Ranran LI
Journal of Central South University(Medical Sciences) 2024;49(1):128-134
Mitochondria are the main site of energy metabolism within cells,generating a substantial amount of ATP to supply energy to the human body.Research has shown that alterations in mitochondrial structure and function exist in individuals with schizophrenia,suggesting their potential impact on the onset of psychiatric disorders and clinical treatment efficacy.Therefore,understanding the research progress on the genetic mechanisms,pathological processes,image manifestations of schizophrenia and mitochondrial quality control,and summarizing the relevant evidence of mitochondrial-related targets as potential therapeutic targets for schizophrenia,can provide references for further research.