Objective To investigate the effects of thermosensitive moxibustion on psoriasis model rats'skin;To discuss its mechanism based on JAK3/STAT3 signaling pathway.Methods 5%imiquimod cream was used on the skin of rats back and along the route of the Sanjiao meridian of hand-shaoyang for psoriasis modeling.The SD rats were randomly divided into blank group,model group and treaament group.The treatment group received moxibustion therapy at"Waiguan"for 40 minutes each time for 7 consecutive days,and were divided into moxibustion group and thermosensitive moxibustion group according to sensitization state.HE staining was used to observe pathological changes in skin lesions,and ELISA was used to detect serum tumor necrosis factor(TNF)-α,interleukin(IL)-1 and IL-23 levels.Immunohistochemistry was used to detect the positive expressions of p-JAK3 and p-STAT3 in the skin lesion tissue,and RT-qPCR was used to detect the mRNA expressions of JAK3,STAT3,IL-17A and IL-17F in the skin lesion tissue.Results Compared with the normal group,model group rats were with protruding and thickened skin lesions accompanied by extensive infiltration of inflammatory cells,the contents of serum TNF-α,IL-1β and IL-23 significantly increased(P<0.01),and the positive expressions of p-JAK3 and p-STAT3 in the skin lesion tissue significantly increased(P<0.01),the mRNA expressions of JAK3,STAT3,IL-17A and IL-17F significantly increased(P<0.01).Compared with the model group,the thickness of the spinous layer in the skin lesions of rats in the thermosensitive moxibustion group was reduced,and there was no significant infiltration of inflammatory cells.The contents of serum TNF-α,IL-1β and IL-23 significantly decreased(P<0.01),and the positive expressions of p-JAK3 and p-STAT3 in skin lesion tissue significantly decreased(P<0.05,P<0.01),the mRNA expressions of JAK3,STAT3,IL-17A and IL-17F significantly decreased(P<0.05,P<0.01).Compared with the moxibustion group,the serum contents of TNF-α and IL-1β in the thermosensitive moxibustion group were significantly decreased(P<0.05,P<0.01),and the positive expression of p-JAK3 in the skin lesion tissue was significantly decreased(P<0.05).Conclusion Thermosensitive moxibustion can improve the pathological symptoms of psoriasis model rats.Its mechanism may be related to the inhibition of the JAK3/STAT3 signaling pathway,reduction of regulatory T cell-17 differentiation and secretion of pro-inflammatory cytokines.

In recent years， with the changes of population structure and the aggravation of aging， the prevalence of osteoporosis is increasing year by year. Osteoporosis poses great impacts on the body and family life of the patients and increases the burden on the society. Therefore， the research on osteoporosis is urgent and significant. The imbalance between osteoblasts， osteocytes， and osteoclasts causes abnormal bone metabolism， which destroys the fine structure of bone and increases bone fragility， thus increasing the risk of fracture. Although the pathogenesis of osteoporosis is complex， researchers have confirmed that the imbalance of the endocrine system directly or indirectly promotes the occurrence and development of osteoporosis. Traditional Chinese medicine （TCM） is a treasure of Chinese traditional culture and plays a key role in safeguarding the public health. With unique therapeutic effects and advantages， TCM has been widely accepted. Chinese medicines， moxibustion， acupuncture and other TCM therapies have play a unique role in the treatment of osteoporosis. Particularly， TCM prevention and treatment of osteoporosis by regulating the endocrine system has received extensive attention. By reviewing relevant literature， this paper introduces the research progress in the TCM modulation of bone metabolism and alleviation of bone loss by regulating estrogen， calcitonin， and parathyroid hormone in the endocrine system and affecting the hypothalamus capable of regulating these hormones， aiming to provide ideas for the TCM treatment of osteoporosis.

With the aging of population， osteoporosis has become one of the main diseases endangering the health of the elderly in China. Therefore， the research on osteoporosis has become a hot spot. Since Chinese medicines demonstrate significant therapeutic effects on osteoporosis， this issue is attracting increasing attention from researchers， especially in the deciphering of the molecular mechanism. This paper introduces the mechanism of the prevention and treatment of osteoporosis by Chinese medicines via the mitogen-activated protein kinase （MAPK） signaling pathway， aiming to provide a theoretical basis for deciphering the mechanism of Chinese medicines in the treatment of osteoporosis and promoting their clinical application. MAPK signaling pathway mainly involves p38 MAPK， extracellular signal-regulated kinase 1/2 （ERK1/2）， c-Jun N-terminal kinase （JNK）， and extracellular signal-regulated kinase 5 （ERK5）. Studies have shown that these proteins play a role in the progression of osteoporosis by regulating cell proliferation， differentiation， and apoptosis. Chinese medicines as a unique therapy with Chinese characteristics has definite efficacy， high safety， and mild side effects. Researchers have proved by experiments that the extracts or compounds of Chinese medicines can significantly mitigate osteoporosis by regulating the proteins involved in the MAPK signaling pathway. Therefore， this article reviews the relevant studies with focus on these proteins.