Objective To analyzed the clinical characteristics of Klebsiella pneumoniae liver abscess as well as the characteristics and drug resistance situationof Klebsiella pneumoniae .Methods The clinical data in 110 cases of Klebsiella pneumoniae liver ab-scess were collected and divided into the other liver diseases group and non-other liver diseases group for conducting the study .The slime test was adopted to determine the high mucus character of Klebsiella pneumoniae .The PCR amplification was used to detect the virulence genes and capsular type and the drug susceptibility test was performed by using the disk diffusion method .Then the results were statistically analyzed .Results Klebsiella pneumoniae liver abscess was common in 40 -80 years old middle aged and elderly males .50 .00% patients had the diabetes base .In 110 strains of Klebsiella pneumoniae ,86 .36% strains had the high mucus phenotype ,the capsular types were dominated by serotype K1 and K2 .The detection rats of phenotype strains ,carrying virulence gene rmpA and aerocin in the non-other liver disease group were significantly higher than those in other liver diseases group ,the difference was statistically significant (P<0 .01) .The resistance rats of Klebsiella pneumoniae to 12 kinds of common antibacterials were lower .Conclusion Klebsiella pneumoniae liver abscess is common in middle aged and elderly males .High mucus and high vir-ulence Klebsiella pneumoniae carrying virulence gene empA and aerocin is main pathogenic bacterium of liver abscess ,w hich has lower resistance rate to common antibacterials .