Proteomics is an emerging discipline which studies the composition of proteins and their transformation rules at the cellular level and the overall level.Recently,proteomics has been used in a variety of studies of tumors.And it has made some progresses in explaining the mechanisms of tumors' genesis and development,discovering new specific markers for tumors and new targets for drug treatment,and forecasting tumors' biological behaviors.

OBJECTIVE:To observe the therapeutic effects of compound glycyrrhizin(CG)combined with Radix Salviae Miltiorrhizae(RSM)on hepatic fibrosis.METHODS:154patients with chronic hepatitis were randomly divided into3groups:trial group(CG+RSM),CG group and RSM group.The serologic parameters of liver functions and hepatic fibrosis were com?pared between pretreatment and posttreatment.RESULTS:The parameters of hepatic fibrosis were decreased in trial group after treatment,in comparison with those of pretreatment,CG group and RSM group,the fifferences were significant(P

OBJECTIVE:To compare the bioequivalence between alfuzosin hydrochloride sustained release tablets and the imported alfuzosin common tablets.METHODS:20 health volunteers were assigned to receive oral single dose of 5mg sustained-release and imported tablets of alfuzosin by self crossover way,with alfuzosin concentration in serum determined by HPLC.The pharmacokinetic parameters were calculated;the statistical analysis was carried out and the bioequiavailability was evaluated.RESULTS:The main pharmacokinetic parameters of the sustained-release and the imported tablets of alfuzosin were as follows:Cmax:(28.92? 9.63) ?g? L-1 vs.(32.92? 10.23) ?g? L-1;tmax:(2.7? 0.6) h vs.(1.4? 1.0) h;AUC0～ ∞:(221.14? 59.46) ?g? h? L-1 vs.(245.68? 67.20) ?g? h? L-1;t1/2:(6.68? 0.85) vs.(4.73? 1.22) h;AUC0～ 24:(215.20? 49.63) vs.(226.30? 53.60) ?g? h? L-1.The relative bioavailability of alfuzosin hydrochloride sustained release tablets was(92.2? 13.2) %.CONCLUSION:The 2 preparations of alfuzosin are bioequivalent.

OBJECTIVE:To put forward suggestions on the standardization of indications for drug storage temperature.METHODS:Based on laws and regulations,the problems were pointed out and the causes were analyzed,and some countermeasures were put forward.RESULTS & CONCLUSIONS:The indications for drug storage temperature had problems in quantization,detailing,standardization and practicalities etc.The key of solving the problems is to establish a set of authori-tative standards and set up the specification for the indications of drug storage tailored for China's own condition and on the basis of safety and practicality.

OBJECTIVE:To provide reference for faciliating the standardization and development of "Clinical Pharmacist System".METHODS:The problems,the causes and the solutions were discussed in view of the basic national conditions and the status quo of clinical pharmacy.RESULTS & CONCLUSIONS:To set up "Clinical Pharmacist System" in China,the key problems such as the legal status of the system,its application scope,the classification(definition),authority and responsibility of clinical pharmacists must be addressed so as to create a clinical pharmacists system with Chinese characteristics that "drawing on collective wisdom and absorbing all useful ideas".

OBJECTIVE:To provide constructive suggestions for the substantial problems related to the warehousing acceptance and recording of drugs in medical institutions. METHODS: We studied the relevant problems, analyzed causes and seek for the countermeasures in accordance with the prevailing laws, codes and administrative rules of the state. RESULTS & CONCLUSIONS: The essential problem for the "recording" of drugs in medical institutions arose from the absence and incompleteness of corresponding laws, codes and administrative rules. The key for the problem is to "rely on and strictly carry out the laws and seriously punish those violating the laws".

OBJECTIVE:To study the extracting and purifying process of Achyranthes bidentata polysaccharides(ABP). METHODS:Crude polysaccharide was obtained by extracting ABP raw material by water decocting method.The Crude polysaccharide was purified(deproteinization,desalination and alcohol precipitation) to obtain ABP.The content of total polysaccharide was taken as an evaluation index to optimize the optimum conditions of extracting and purifying.RESULTS: The optimum water decoction conditions were as follows:ABP raw material was extracted three times (2 h/time) by adding 10 times amount of water.As for the deproteinization process,TCA(trichloracetic acid) method was superior to Sevage method and tannic acid method;Desalination by molecular sieve was superior to that by dialysis method; and alcohol precipitation was performed with 80% alcohol.CONCLUSION:ABP can be prepared by water decoction,deproteinization,desalination and alcohol precipitation of its raw material.

OBJECTIVE: To provide constructive suggestions aimed at the problems in the implementation of Prescription Administration Method(Method in short).METHODS: The problems were studied,the causes were analyzed and the countermeasures were discussed in light of the related state laws and codes as well as the present status and the basic national condition of prescription administration.RESULTS & CONCLUSIONS: The Method is insufficient in logic,standardization,rationality and compactness and lack in maneuverability.It is advisable to make explanations on the rules with the same legal effect or revise the rules according to the new conditions appeared after the implementation of the Method so as to achieve strict logic of certain contents,exactness in words,standardization,rationality,strictness,specific and maneuverability of clause and contents.

OBJECTIVE:To provide constructive suggestions on common problems appeared in the "compliance" illegal drugs in hospital pharmacy. METHODS: The problems, reasons and countermeasures related to the "compliance" illegal drugs in hospital pharmacy were studied in accordance to Drug Management Law and the relative rules of National Drug Supervision Department. RESULTS & CONCLUSIONS: Some "Compliance" illegal drugs exist in hospital pharmacy of China, and they have problems in storing temperature and expiration date, etc.; therefore, the government should take decisive measures to eliminate the production, circulation and use of the "Compliance" illegal drugs in the fields of drug manufacturing, business and medical institutions.

OBJECTIVE: To explore the arrangement of the Chinese medicine cabinet.METHODS: By using computer Excel program and combining the experiences in the cabinet arrangement of traditional Chinese medicine(TCM),we divided the factors need to be considered in TCM cabinet arrangement into three layers: zone,bucket and lattice.RESULTS: A new arrangement of the TCM cabinet was presented.CONCLUSION:The new cabinet arrangement method is scientific,reasonable,practical and helpful for the concerned parties.