Proteomics is an emerging discipline which studies the composition of proteins and their transformation rules at the cellular level and the overall level.Recently,proteomics has been used in a variety of studies of tumors.And it has made some progresses in explaining the mechanisms of tumors' genesis and development,discovering new specific markers for tumors and new targets for drug treatment,and forecasting tumors' biological behaviors.

Cerebral Palsy ; complications ; Child ; Child Nutrition Disorders ; complications ; Deglutition Disorders ; Equipment and Supplies ; Esophageal Motility Disorders ; etiology ; therapy ; Humans ; Speech Disorders ; etiology

Humans ; Purpura, Thrombocytopenic, Idiopathic

Diagnosis, Differential ; Genome ; Human Genome Project ; Humans ; Medicine, Chinese Traditional

Genome ; Human Genome Project ; Humans ; Medicine, Chinese Traditional ; trends

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors.To date,three isotypes of PPARs called PPARα,PPARγ and PPARβ/δ have been identified.The relationship between PPARγ and fibrosis disease has increasingly drawn people's attention.PPARγ is activated by its ligands or agonists plays an important role in the control of fibrosis through their effects on various cellular processes,including anti-inflammatory,inducing cellular apoptosis and differentiation,anti angiogenesis,antioxidative and anti-proliferative effects,which is expected to be a new way to treat ocular diseases.The role of PPAR-γ and its agonist in ocular diseases,including PPARs and its distribution,the structure and function of PPAR-γ,PPAR-γ ligands and agonist,activation of PPAR-γ,PPAR-γ in the expression of eye tissues,and the role of PPAR-γ and its agonist in ocular diseases were reviewed.

In a variety of pathological conditions,capillaries grow from corneal limbus to the central cornea area,to form corneal neovascularization (CNV).CNV destroys the normal corneal microenvironment, reduces the transparency of cornea, seriously affects visual acuity and leads to corneal transplantation immune rejection.Corneal microenvironment includes inflammatory mediators, cytokines and extracellular matrix (ECM).Studies showed that corneal microenvironment changes have a close relationship with CNV.This article reviewed the relationship of corneal microenvironment with CNV.

Neovascular glaucoma (NVG) is a kind of devastating secondary glaucoma characterized by neovascularization in iris and anterior chamber angle,which often results in loss of vision.The current standard of treatment includes retinal ablation and control of enhanced intraocular pressure with drugs and surgical therapy.There are a lot of surgical therapies of NVG,while the prognosis of these therapies are not satisfactory as most of them would be effected by different kinds of complications.Ahmed glaucoma valve implantation (AGVI) is one of the main treatments means being widely used with less postoperative complications,such as shallow anterior chamber,low intraocular pressure.Failure of AGVI mainly caused by fiber hyperplasia and neovascularization.AGVI combined with anti-fibrosis therapy and anti-vascular endothelial growth factor (VEGF) therapy might be a promising method to promote surgical outcomes.It has been shown that AGVI combined with anti-VEGF drugs can improve the success rate of surgery.Besides,some researchers found that AGVI with intraoperative application of anti-fibrosis drugs,such as mitomycin C,sustained-release anti-fibrosis drugs can improve the prognosis of surgery in neovascular glaucoma patients.The progress of research on anti-fibrosis and anti-VEGF treatment combined with Ahmed glaucoma valve implantation was discussed in this review.

As a Y-box transcdption factor,ZONAB performs biological functions of promoting the proliferation and inhibiting the differentiation of epithelial cells,regulating the function of tight junctions,as well as promoting the epithelial-mesenchymal transition.ZONAB plays its transcriptional activity by interacting with other tight junction elements and genes,proteins,enzymes and transcription factors which are enrolled in the cell cycle.Meanwhile,its transcriptional activity is also regulated by many other factors.ZONAB takes part in the proliferation,differentiation of epithelial cells,stress reaction,organogenesis and oncogenesis progress,which has been proved to be associated with the genesis and development of many diseases.The regulation mechanism and clinical significance of ZONAB has been the focus at home and abroad.

Aim To investigate the effects of xy9902 on the proliferation and differentiation in MC3T3-E1 cells and its mechanism.Methods Effects of xy9902 on the proliferation and differentiation of MC3T3-E1 cells was determined by MTT and ALP activity measurement.Competitive estrogen-receptor binding assay was used to investigate the affinity of xy9902 to ER.Results xy9902 induced cell proliferation and increased alkaline phosphatase(ALP) activity of MC3T3-E1 cells.Antiestrogen tamoxifen eliminated the stimulation of proliferation and ALP activity of MC3T3-E1 induced by xy9902.The relative binding affinity of xy9902 for ER? and ER? showed an IC_(50)of 8.45?10~(-6) mol?L~(-1) and 1.66?10~(-6) mol?L~(-1) respectively.Conclusion xy9902 directly stimulates cell proliferation and differentiation of MC3T3-E1 cells through ligand-receptor binding,which indicated that xy9902 behaves as an estrogen agonist in MC3T3-E1 cells.