1.Effects of Nutrition Consultation on Nutritional Status in Critically Ill Surgical Patients.
Hee Sook HWANG ; Seung Hwan LEE ; Hosun LEE ; Kyung Sik KIM ; Seo Jin CHUNG ; Jae Gil LEE
Journal of Clinical Nutrition 2015;7(1):28-34
PURPOSE: The aim of this study was to investigate nutritional support status and effects of nutrition consultation in critically ill surgical patients. METHODS: The medical records of 76 patients, admitted between June 1 and November 30, 2013, were reviewed retrospectively. Patients were divided into 2 groups: the nutrition consultation group (n=17) and the no consultation group (n=59). Patients were also divided into 3 groups: the enteral nutrition (EN) group (n=8), the parenteral nutrition (PN) group (n=25), and the enteral and parenteral mixed nutrition (ENPN) group. Total delivered/required caloric ratio and serum albumin, serum total protein, hemoglobin and other biochemical variables were compared in each group. RESULTS: Mean daily required and delivered caloric/protein amount were EN group 60.0%, PN group 64.6%, and ENPN group 86.9%. ENPN group showed statistically significant difference when compared with EN group, PN group (P=0.005). When the proportion of patients who were fed more than 75% of the daily required calories was calculated, EN, PN, and ENPN showed 37.5%, 25.0% and 81.8%, respectively. ENPN group were significantly more supplied (P=0.007). Although neither the nutrition consultation group nor the non-consultation group received more than 80% of the daily required calories, the nutrition consultation group received 73% of the daily required calories whereas the no consultation group only received 46% (P=0.007). The total delivered/required protein ratio was approximately 69% of the nutrition consultation group and approximately 42% of the no consultation group (P=0.006). CONCLUSION: The results of providing nutritional consultation to intensive care unit patients showed an increase in the nutrition support. Nutrition education, continuous monitoring and management for nutritional support by systemic administration of a nutritional support team should be considered in order to achieve effective clinical outcomes in critically ill surgical patients.
Critical Illness*
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Education
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Enteral Nutrition
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Humans
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Intensive Care Units
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Medical Records
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Nutritional Status*
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Nutritional Support
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Parenteral Nutrition
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Retrospective Studies
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Serum Albumin
2.Points to consider when developing drugs for dry eye syndrome
Suyoung BAE ; Hosun SEUNG ; Ho Jung OH
Osong Public Health and Research Perspectives 2023;14(2):70-75
Changes in both the social environment (e.g., the increased use of electronic media) and the atmospheric environment (e.g., air pollution and dust) have contributed to an increasing incidence of eye disease and an increased need for eye care. Notably, the signs and symptoms of dry eye syndrome can impact the daily quality of life for various age groups, including the elderly, and usually requires active treatment. The symptoms of dry eye syndrome include tear film instability, hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities. As treatments for dry eye are being developed, a standardized guideline is needed to increase the efficiency of drug development and improve the quality of clinical trial data. In this paper, we present general considerations for the pharmaceutical industry and clinical trial investigators designing clinical trials focused on the development of drugs to treat dry eye syndrome.
3.Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea.
Jung Hye HWANG ; Jeong Wook KIM ; Ji Young HWANG ; Kyung Min LEE ; Hye Min SHIM ; Young Kyung BAE ; Seung Sam PAIK ; Hosun PARK
Yonsei Medical Journal 2014;55(6):1562-1567
PURPOSE: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS AND METHODS: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR. RESULTS: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. CONCLUSION: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
Abortion, Missed/*etiology
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Adult
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Coxsackievirus Infections/complications/*diagnosis/virology
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Enterovirus B, Human/genetics/*isolation & purification
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Female
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Humans
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Immunohistochemistry
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Placenta/virology
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Pregnancy
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Pregnancy Complications, Infectious/*virology
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Pregnancy Trimester, First
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Prevalence
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Prospective Studies
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Republic of Korea
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Analysis, DNA
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Uterus/*virology
4.Real-world effectiveness and safety of adalimumab in Korean patients with intestinal Behcet’s disease: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter study
Seung Bum LEE ; Hee Seung HONG ; Chang Kyun LEE ; Bo-In LEE ; Sol KIM ; Seong-Joon KOH ; Hosun YU ; Jung-Bin PARK ; Sung Wook HWANG ; Byong Duk YE ; Suk-Kyun YANG ; Sang Hyoung PARK ;
The Korean Journal of Internal Medicine 2023;38(5):661-671
Background/Aims:
The short- and long-term effects of adalimumab (ADA) on Korean patients with intestinal Behcet’s disease (BD) for remain unclear. Therefore, a multicenter study was performed to evaluate the efficacy and safety of ADA in Korean patients with intestinal BD in a real-world setting.
Methods:
The medical records of 67 patients with BD prescribed ADA between January 2012 and December 2020 at five referral centers in Korea were retrospectively analyzed and the safety and efficacy of ADA within 52 weeks were assessed. To evaluate the clinical efficacy of ADA, the Disease Activity Index for Intestinal BD (DAIBD) and representative blood biochemical markers were compared at 0, 12, 24, and 52 weeks of ADA treatment.
Results:
During the follow-up period of 52 weeks, 46 patients continued ADA treatment. The cumulative drug survival rate was 83.5%. The DAIBD score decreased over the study period (p < 0.001). Moreover, the erythrocyte sedimentation rate, serum C-reactive protein levels, and serum albumin levels significantly improved at 12, 24, and 52 weeks of ADA treatment (all, p <0.05).
Conclusions
As ADA is effective for refractory intestinal BD with few safety concerns in real-world situations, it is a potential treatment option for Korean patients with intestinal BD.
5.The Use of Health Functional Foods in Gastrointestinal Cancer Patients.
Hwa Pyoung KANG ; Hosun LEE ; Tak Geun OH ; Kyong Joo LEE ; Soo Jung PARK ; Moon Jae CHUNG ; Seung Up KIM ; Hyuk LEE ; Jun Chul PARK ; Sung Pil HONG ; Jun Yong PARK ; Jeong Youp PARK ; Seungmin BANG ; Do Young KIM ; Jae Hee CHEON ; Sang Hoon AHN ; Tae Il KIM ; Seung Woo PARK ; Si Young SONG
Clinical Nutrition Research 2013;2(1):19-25
As an adjunct to cancer treatment, the use of health functional foods (HFFs) seems to be increasing. However, little is known for the use of HFFs among cancer patients in Korea. The aims of this study were to investigate the exposure rate of HFF use among gastrointestinal (GI) cancer patients and to examine the relationship of socio-demographic and disease-related characteristics with the use of HFFs. A total of 126 patients diagnosed with GI cancer participated in the study. A cross-sectional survey was conducted using a questionnaire. Over a half of all the patients surveyed (n = 67; 53.2%) used HFFs. Patients who were younger, had higher income, or longer duration of disease showed a trend to use HFFs more frequently, even though the tendency was not statistically significant. The most commonly used HFF was vitamin complex (n = 20; 16%), followed by red ginseng (n = 15; 12%), and sweet wormwood (Artemisia annua) (n = 11; 8.8%). About 26% of all responders expressed concerns for using HFFs. The primary concern was 'going against physician's recommendations' (36.8%). About 63% of respondents expressed a desire to consult with their physicians and follow their recommendations. More basic scientific data and educational materials regarding HFFs are required for both health-care professionals and cancer patients. A larger sample and size-controlled groups representing each cancer type will continue to be recruited for participation in this survey.
Artemisia
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Cross-Sectional Studies
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Surveys and Questionnaires
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Functional Food*
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Gastrointestinal Neoplasms*
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Humans
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Korea
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Panax
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Vitamins