The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6~31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.
Anastomosis, Surgical/veterinary ; Animals ; Benzamides/*pharmacology ; Cecum/*drug effects/physiology ; Electrophysiology ; Female ; Gastrointestinal Agents/*pharmacology ; Gastrointestinal Motility/*drug effects ; Horses/*physiology/surgery ; Intestine, Small/*drug effects/physiology/surgery ; Jejunostomy/veterinary ; Male ; Morpholines/*pharmacology