1.Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease
Jin cheol SEO ; Jin young WON ; Keon woo KIM ; Jung hyung PARK ; Hyeon-Gu YEO ; Yu Gyeong KIM ; Seung Ho BAEK ; Hoonwon LEE ; Chang-Yeop JEON ; Won Seok CHOI ; Sangil LEE ; Ki Jin KIM ; Sung-Hyun PARK ; Yeong hoon SON ; Kang Jin JEONG ; Kyung Seob LIM ; Philyong KANG ; Hwal-Yong LEE ; Hee-Chang SON ; Jae-Won HUH ; Young-Hyun KIM ; Dong-Seok LEE ; Sang-Rae LEE ; Ji-Woong CHOI ; Young jeon LEE
Experimental Neurobiology 2020;29(5):376-388
ymptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.
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