1.Three cases of benign symmetric lipomatosis.
Yeol Oh SUNG ; Jeung Hoon LEE ; Kyung Hoon KIM ; Mu Kyu SUH ; Jang Kyu PARK
Korean Journal of Dermatology 1993;31(5):800-805
Benign symmetric lipomat,osis is a rare disease of undetermined cause characterized by symmetric deposits of adipose tissue o:n the neck, upper trunk and abdomen. We report three cases of kienign symmetric lipomatosis, one of which is associated with alcoholic liver disease and the patient complained of a diffieulties in neck motion, All of them are about sixty year old men with history of frequent alcohol consumption. In histopathologic findings, the reticular dermis was completcly replaced by mature fat cells and there was a slight increase in vascular and fibrous elements.
Abdomen
;
Adipocytes
;
Adipose Tissue
;
Alcohol Drinking
;
Dermis
;
Humans
;
Lipomatosis*
;
Liver Diseases, Alcoholic
;
Male
;
Neck
;
Rare Diseases
2.Two Cases of Seckel Syndrome.
Kyu Chang PARK ; Phil Soo OH ; Jeh Hoon SHIN
Journal of Korean Society of Pediatric Endocrinology 1998;3(2):228-230
Seckel syndrome is a rare, autosomal recessive disorder of severe growth retardation and distinct craniofacial, orodental, and skeletal anomalies. We report hereby the first two Korean cases of typical Seckel syndrome who had characteristic symptoms of intrauterine growth retardation, small head, large eyes, sharp facial features (beaked nose, dysplastic ears and narrow face) with underdeveloped chin, dwarfism, severe mental retardation, and other malformation. We report two cases of Seckel syndrome with a brief review of related literatures.
Chin
;
Dwarfism
;
Ear
;
Fetal Growth Retardation
;
Head
;
Intellectual Disability
;
Nose
3.Changes in Blood Superoxide Dismutase Activities after Alcohol Withdrawal.
Jin Sook CHEON ; Kyu Cheon LEE ; Byoung Hoon OH
Journal of the Korean Society of Biological Psychiatry 1999;6(2):219-226
OBJECTIVES: The aims of this study were to evaluate changes in plasma superoxide dismutase(SOD) activities in alcohol depedence, to fine out variables to influence on the SOD activities, and finally to identify the correlation of SOD activities with the alcohol-associated cognitive disorders. METHODS: For 24 male alcoholics and 21 healthy male controls, plasma SOD activities were measured by spectrophotometry on 1-2 wks after alcohol withdrawal. Structured interviews and laboratory tests were also performed. RESULTS: 1) Upon comparing SOD activities between controls and alcoholics, the SOD activities were significantly(p<0.01) lower in alcoholics(0.308+/-0.140 units/mL) than in healthy controls(0.313+/-0.086 units/mL). 2) Upon comparing SOD activities according to the presence of alcohol-related cognitive disorders, the SOD activities were significantly(p<0.05) lower in alcoholics with cognitive disorders(0.247+/-0.049 units/mL) than in alcoholics without cognitive disorders(0.317+/-0.148 units/mL). 3) Upon comparing SOD activities according to the presence of alcoholic polyneuropathy or alcohol withdrawal seizure, the SOD activities showed no significant differences between alcoholics with polyneuropathy or epilepsy and those without. 4) Upon analyzing variables influencing on the SOD activities in alcoholics, the SOD activities had the negative correlation with hemoglobin(gamma=-0.433) and severity of alcohol withdrawal symptoms(gamma=-0.375). 5) Upon comparing variables according to the presence of alcohol-related cognitive disorders, the occurrence of alcoholic polyneuropathy(p<0.05) and blood phosphorus concentrations(p<0.01) were significantly higher in alcoholics with cognitive disorders than those without. 6) Upon analyzing an association between SOD activities and variables in alcoholics with cognitive disorders, the SOD activities were positively correlated with the onset age(gamma=0.995), and negatively correlated with the severity of alcohol withdrawal symptoms(gamma=-0.996). CONCLUSIONS: Lower SOD activities in alcohol dependence suggested alcohol-associated cognitive disorders and alcohol withdrawal symptoms might be caused by oxidative stress.
Alcohol Withdrawal Seizures
;
Alcoholic Neuropathy
;
Alcoholics
;
Alcoholism
;
Epilepsy
;
Humans
;
Male
;
Oxidative Stress
;
Phosphorus
;
Plasma
;
Polyneuropathies
;
Spectrophotometry
;
Substance Withdrawal Syndrome
;
Superoxide Dismutase*
;
Superoxides*
4.Malignant Lymphoma of Mucosa-associated Lymphoid Tissue Arising in the Conjunctiva.
Tae Kyung KIM ; Jang Oh KIM ; Sang Won KIM ; Hoon Kyu OH ; Jae Bok PARK
Annals of Dermatology 1995;7(3):273-277
We report two cases of malignant lymphoma of mucosa-associated lymphoid tissue arising in the conjunctiva. Case 1, an 18-year-old girl, showed her left lower conjunctival swelling for four months and Case 2, a 29-year-old man, showed similar lesions on both his eyes for one year. Histologically, both cases revealed monomorphous dense lymphoid infiltrates invading the overlying conjunctival epithelium with diffuse patterns. The infiltrates were composed of small lymphocytes admixed with centrocyte-like cells within the conjunctival epithelium and stroma in association with B-cell lineage. No relapse was noted during the period of about 1½ years follow-up in case 1 treated by local excision only and in the follow-up period of 2 months in case 2 treated by local excision and subsequent chemotherapy.
Adolescent
;
Adult
;
B-Lymphocytes
;
Conjunctiva*
;
Drug Therapy
;
Epithelium
;
Female
;
Follow-Up Studies
;
Humans
;
Lymphocytes
;
Lymphoid Tissue*
;
Lymphoma*
;
Recurrence
5.The impact of beam angle configuration of intensity-modulated radiotherapy in the hepatocellular carcinoma.
Sung Hoon KIM ; Min Kyu KANG ; Ji Woon YEA ; Sung Kyu KIM ; Ji Hoon CHOI ; Se An OH
Radiation Oncology Journal 2012;30(3):146-151
PURPOSE: This treatment planning study was undertaken to evaluate the impact of beam angle configuration of intensity-modulated radiotherapy (IMRT) on the dose of the normal liver in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The computed tomography datasets of 25 patients treated with IMRT for HCC were selected. Two IMRT plans using five beams were made in each patient; beams with equidistance of 72degrees (Plan I), and beams with a 30degrees angle of separation entering the body near the tumor (Plan II). Both plans were generated using the same constraints in each patient. Conformity index (CI), homogeneity index (HI), gamma index, mean dose of the normal liver (Dmean_NL), Dmean_NL difference between the two plans, and percentage normal liver volumes receiving at least 10, 20, and 30 Gy (V10, V20, and V30) were evaluated and compared. RESULTS: Dmean_NL, V10, and V20 were significantly better for Plan II. The Dmean_NL was significantly lower for peripheral (p = 0.001) and central tumors (p = 0.034). Dmean_NL differences between the two plans increased in proportion to gross tumor volume to normal liver volume ratios (p = 0.002). CI, HI, and gamma indices were not significantly different for the two plans. CONCLUSION: The IMRT plan based on beams with narrow separations reduced the irradiated dose of the normal liver, which would allow radiation dose escalation for HCC.
Carcinoma, Hepatocellular
;
Humans
;
Liver
;
Radiotherapy, Intensity-Modulated
;
Tumor Burden
6.Lumbar Spinal Instability and Its Radiologic Findings.
Kyoung Hoon YANG ; Nam Kyu KIM ; Young Soo KIM ; Yong KO ; Seong Hoon OH ; Suck Jun OH ; Kwang Myung KIM
Journal of Korean Neurosurgical Society 2000;29(1):78-86
No abstract available.
7.Nasal Type NK/T Cell Lymphoma with Pseudoepitheliomatous Hyperplasia: A Case Report.
Hoon Kyu OH ; Jeong Kyu KIM ; Kwan Kyu PARK
Korean Journal of Pathology 2006;40(3):250-254
A case of prominent pseudoepitheliomatous hyperplasia (PEH), that was misdiagnosed as squamous cell carcinoma (SCC) on the frozen section occured in the nasal mucosa of a patient suffering with nasal type NK/T cell lymphoma. To prevent misdiagnosis of this lesion, pathologists should be aware that NK/T cell lymphoma may be associated with overlying mucosal PEH, and so the physician must adhere to strict diagnostic criteria for making the diagnosis of SCC. The pathogenesis of PEH associated with NK/T cell lymphoma is not still clear, but it may be related to the production of growth factors, especially epidermal growth factor and transforming growth factor, by the underlying tumors.
Carcinoma, Squamous Cell
;
Diagnosis
;
Diagnostic Errors
;
Epidermal Growth Factor
;
Frozen Sections
;
Herpesvirus 4, Human
;
Humans
;
Hyperplasia*
;
Intercellular Signaling Peptides and Proteins
;
Lymphoma*
;
Nasal Mucosa
;
Transforming Growth Factors
8.The Structural Properties of Israeli Carp ( Cyprinus carpio L. ) Immunoglobulin.
Sang Hoon CHOI ; Jong Kyu WOO ; Yong Suk JANG ; Chan Ho OH
Korean Journal of Immunology 1999;21(1):85-92
Serum immunoglobulins from Israeli carp (I. carp) were purified using affinity chromatography. Fish were immunized with purified mouse IgG, and the specific fish antibodies purified from the immune serum on a mouse IgG-immobilized agarose gel. Rabbit anti-carp Ig (Raclg) antibodies were produced following hyperimmunization with mlgG specific I. Carp Ab. SDS-PAGE analysis under reducing condition showed that I. carp Ig (clg) were composed of two u-like heavy chains with about 82 and 50 kD, respectively and one light chain with about 25 kD. On immunoblotting analysis, however, Raclg failed to react with light chain. When both protein A and protein G purified normal clg were compared with mlgG specific clg, no significant structural differences among them were observed. To investigate if there is any homology between other fish Ig molecules, cross-reactivity of Raclg against Ig molecules from 6 different fish sera and mouse control serum was checked on immunoblotting analysis. As a result, Raclg responded to only carp and tilapia Ig molecules, indicating that both tilapia and carp are very closely associated, especially, in the genetic basis of immunoglobulin structure. In flow cytometry study, Raclg appeared to recognize 45.8% of carp Ig+, 14.5% of catfish Ig+ and <5% of tilapia Ig+ cells. The result suggest the heterogeniety between receptor immunoglobulins on B-like lymphocytes and soluble immunoglobulins in serum. It is crucial to obtain pure fish immunoglobulins to produce reagent antibodies as tools for the study of their specific immune response.
Animals
;
Antibodies
;
Carps*
;
Catfishes
;
Chromatography, Affinity
;
Electrophoresis, Polyacrylamide Gel
;
Flow Cytometry
;
Immunoblotting
;
Immunoglobulin G
;
Immunoglobulins*
;
Lymphocytes
;
Mice
;
Sepharose
;
Staphylococcal Protein A
;
Tilapia
9.Analysis of Pulmonary Asbestos Body in Malignant Mesothelioma: A case report.
Hoon Kyu OH ; Jae Yoe RO ; Chul Jong YOON ; Je Geun CHI
Korean Journal of Pathology 1999;33(5):361-366
The association between occupational asbestos exposure and the subsequent development of malignant mesothelioma of pleura is well recognized. We analyzed an asbestos body by energy dispersive X-ray analyser in a case of malignant mesothelioma of pleura who had a history of asbestos exposure 30 years ago. In transmission electron microscope, the asbestos body was composed of a core of refractile thin asbestos fiber bundle and beaded masses of electron-dense iron and protein complex. The core fibers were analyzed as an amphibole type crocidolite fiber [(Na2Fe3Fe2(Si8O22)(OH)2] which composed of high content of silicon, iron and sodium.
Asbestos*
;
Asbestos, Crocidolite
;
Iron
;
Mesothelioma*
;
Pleura
;
Silicon
;
Sodium
10.A Case of Telangiectatic Osteosarcoma of the Skull Base.
Yeungnam University Journal of Medicine 1999;16(2):364-368
A rare case of telangiectatic osteosarcoma of the sphenoid bone was reported. The patient was a 27-year-old male and had suffered from left eye protrusion and diplopia for three months. Radiologically, a lobulated osteolytic lesion was located between sphenoid and left temporal bone. Pathologically, the tumor had multiloculated blood filled cystic vascular spaces and osteoid formation by malignant spindle osteoblast cells. The differential diagnosis of this rare entity from aneurysmal bone cyst was important radiologically and pathologically. This case is the second case of telangietatic osteosarcoma of the sphenoid bone followed by a case of Whitehead RE and Melhem ER in 1998.
Adult
;
Aneurysm
;
Bone Cysts
;
Diagnosis, Differential
;
Diplopia
;
Humans
;
Male
;
Osteoblasts
;
Osteosarcoma*
;
Pathology
;
Skull Base*
;
Skull*
;
Sphenoid Bone
;
Temporal Bone