No abstract available.
Femur* ; Osteomyelitis*

No abstract available.
Carcinoma, Papillary* ; Mediastinum*

No abstract available.
Carcinoma, Papillary* ; Mediastinum*

Equinus deformity of ankle, adduction and flexion deformity of hip and flexion contracture of knee are most common deformities in spastic cerebral palsy. There were many surgical treatment methods according to its causes. Authors has analysed 115 patients(224 operation) who had been operated with three procedure (Modified Egger's op, Proximal hamstring elongation, Distal hamstring elongation) and compared the results of these procedure at Sam Yook Rehabilitation Center from Jan. 1980 to Dec. 1987. The following results are obtained: 1. The results of Modified Egger's operation were unsatisfied because of complicaLion and little angle correction ability of flexion contracture of knee joint. 2. Even though there was no differences in angle correction ability of flexion contracture of knee joint between two procedures, the results of proximal hamstring elongation were superior to them of distal elongtion because early walking ability is more easily improved.
Ankle ; Cerebral Palsy ; Congenital Abnormalities ; Contracture ; Equinus Deformity ; Hip ; Knee Joint ; Knee ; Muscle Spasticity ; Rehabilitation Centers ; Walking

No abstract available.
Myocardial Ischemia* ; Solitary Pulmonary Nodule*

No abstract available.
Child* ; Humans ; Hypertension, Portal*

No abstract available.
Adenoma, Pleomorphic* ; Neurilemmoma*

No abstract available.
Thyroid Gland* ; Thyroid Nodule*

OBJECT: Docetaxel(Taxol), which has been used for breast cancer and ovarian cancer and cisplatin were applied to KB and HOS cell lines. Relative cytotoxicity of each drug to cell lines and its efficiency was evaluated and analyzed for clinical application. METHOD AND METERIAL: Groups were defined by drugs and cell lines combination and were evaluated. We cultured cell line under routine environment and determined optimal cell number and drug concentration. Drugs were applied to cell lines and we measured the optical density with ELISA after MTT application. Statistical analysis was made and clinical availability was evaluated. IC50 and assay AUC could be calculated. Clinical availability was evaluated and comparisons of anti-tumor effect of each drug on cell lines were performed. RESULTS: 1. Anti-tumor effects of taxol and cisplatin on each cell lines showed time and dose dependent relations with significance statistically. 2. Assay AUC in IC50 was higher than clinically achievable AUC in all groups except cisplatin-KB group. Anti-tumor effect of taxol to KB cell line was higher than that of cisplatin in concentration calculated from the clinically achievable AUC. So, we could suggest that taxol could be also used as a antitumor durg for oral cancer. Further study that is, in vivo study, evaluation of combination therapy with other drug, and method of increasing of AUC would be necessary.
Area Under Curve ; Breast Neoplasms ; Carcinoma, Squamous Cell* ; Cell Count ; Cell Line* ; Cells, Cultured ; Cisplatin* ; Enzyme-Linked Immunosorbent Assay ; Humans ; Inhibitory Concentration 50 ; KB Cells ; Mouth Neoplasms ; Osteosarcoma* ; Ovarian Neoplasms ; Paclitaxel*

The p53 protein was discovered in 1979 as cellular 53-kD nuclear phosphoprotein bound to the large transforming antigen of SV40 virus. P21WAF1/CIP1, which has been described as the critical downstream mediator of p53, is known to suppress DNA replication and arrest the G1 cell cycle by quaternary complex with cyclin D, cyclin-dependent kinase(CDK) and proliferating cell nuclear antigen(PCNA). In these days, some studies shows that the p21 can be induced by independent pathways. There are various reports about the expression of p21 (67%.82.4%) in oral squamous cell carcinoma. But these studies are mostly done in malignant tumor not in benign tumor. So we decided to study the expression of p21 in ameloblastoma and the relationship between p53 and p21 as a downstream mediator of p53 in ameloblastoma. We investigated the expression of p21 and p53 with the method of immunohistochemistry. We selected 30 cases of ameloblastoma tissue blocks (acanthomatous type: 5 cases, follicular type: 8 cases, plexiform type: 17 cases) imbedded in paraffin. We used 30 cases of normal gingival tissues and 30 cases of squamous cell carcinoma tissues (SCC) respectively and compared their results with those of ameloblastoma. We made slides with the streptavidin-biotin methods and used monoclonal antibody DO-7 (Novocastra, Newcastle, United Kingdom) as p53 antibody and monoclonal antibody M7202 (DAKO, California, U.S.A.) as p21 antibody. We used Pearson's correlation coefficient to analyse the relationship. The results were as follows: 1. p21 was expressed in ameloblastoma about 30% and this is lower than that of normal gingiva and SCC. 2. In normal gingiva and ameloblastoma, p21 expression was correlated with p53 expression. 3. In SCC, p21 were expressed about 83.3% and this is more than that of p53. But there was no correlation between p21 and p53 expression. We confirmed p21 expression and relation with p53 in ameloblastoma. But, to confirm the function of p21, more studies about p21 expression in malignant ameloblastoma and ameloblastic carcinoma are needed.
Ameloblastoma* ; Ameloblasts ; California ; Carcinoma, Squamous Cell ; Cell Cycle ; Cyclin D ; DNA Replication ; Gingiva ; Immunohistochemistry ; Paraffin ; Simian virus 40