Objective To evaluate the alteration of coagulogram in patients with polycystic ovary syn -drome(PCOS).Methods Coagulogram was compared between 48 patients with PCOS and 42 healthy women. Pre-and post-therapy coagulogram were also compared and the correlation of coagulogram alternation and endocrine indicators were analyzed in PCOS patients .Results The mean age of the 48 PCOS patients was 27.6 ±4.2. Compared to the healthy women , PCOS patients presented higher body mass index , testosterone , insulin and fast-ing blood glucose levels ( P＜0.05 ) .Refer to the coagulogram , PCOS patients showed shorter prothrombin time and activated partial thromboplastin time , lower international normalized ratio of prothrombin time ratio , and the activity of thrombin(P＜0.05), longer thrombin time and lower fibrinogen , D Dimer and fibrin degradation prod-uct levels(P＜0.05).After three circles of treatment, the above indicators of coagulogram were recovered (P＜0.05).Moreover, the alteration of international normalized ratio was associated with fasting blood glucose and in-sulin significantly(P＜0.05).The alteration of D Dimer and fibrin degradation product were associated with fast-ing blood glucose, insulin and testosterone significantly (P＜0.05).Conclusions PCOS patients showed relative hypercoagulatory and hypofibrinolytic status which may be induced by hyperglycemia , hyperinsulinemia and hyper androgenemia.Thus, coagulogram should be monitored and interfered in PCOS patients to prevent thrombosis .

Objective To investigate the related risk factors of hypertensive disorders complicating pregnancy (HDCP).Methods Data of 1265 cases of pregnant women were retrospectively analyzed,and the risk factors of HDCP were analyzed statistically.Results Among the total 1265 pregnant women,HDCP occurred in 124 cases,with an incidence of 9.8％.The incidence of HDCP was 14.6％ (37/254),11.3％ (94/829) and 11.2％ ( 101/903 ) respectively in women ＞35 years,women living in rural areas,and women without prenatal screening,which was significantly higher than that in women ＜ 35 years,women living in urban areas,and women receiving prenatal screening.The difference had statistical significance( P ＜0.05 ).Primipara and women who had abortion history also had higher incidence of HDCP than multipara and women without abortion history,however,the difference had no statistical significance ( P ＞0.05 ).Additionally,logistic regression analysis showed that age,location and prenatal examination were associated with incidence of HDCP.Conclusions Old age,rural residence and lack of prenatal screening were the risk factors of HDCP.In order to prevent HDCP,prenatal screening should be popularized for pregnant women,especially women in rural areas.More attention should be paid to the pregnant women who are over 35 years,living in rural area and lacking of prenatal screening.

[Objective]To review the effect of treatment in chronic kidney disease and its preparation of Cordyceps sinensis. [Methods] By searching and reading the literature, to study the therapeutic effects of Cordyceps sinensis and its preparation on chronic kidney disease.[Results] Cordyceps and its prepa-ration could significantly decrease the proteinuria in patients with chronic kidney disease, serum creatinine level, significant improvement in renal fibrosis, and delay the progression of renal function. [Conclusion] Cordyceps and its preparation have obvious curative effect on chronic kidney disease.

Objective To investigate the clinical application value of padded molars.Methods Totally 54 cases of malocclusions from Department of Orthodontics of West China Hospital of Stomatology were received occlusal pads by optiband ultra band bongding at the early stage of orthodontic treatment (1th -5thmonth).The lateral cephalometric radiographs before and after treatments were analyzed.The effects on vertical height of molars after using padded molars were observed.Results The padded molars did not affect the vertical height without statistical difference (P ＞ 0.05).Conclusions Temporary using padded molars were feasible in orthodontic treatment.Padded molars may be widely applied in clinical orthodontics.

Unit discharges of neurons of the hypothalamic ventromedial nucleus region (HVM) and its surrounding structures including paraventricular nucleus, anterior hypothalamic area,and hypolhalamic dorsomcdial nucleus, were recorded in the ureth-ane-anesthetized and flaxidel-immobilized rats. In HVM,8 of 82 units showed periodical fluctuations in discharge rate, which could be categorized into two types: (1) With alternating active and silent phases 5 (2) with gradually waxing and waning phases. The duration of cach cycle varied from 1 to 5 minutes in different neurons. The periodicity disappeared after intraperitoneal injection of nembutal, while the average discharge rate was raised somewhat. This result suggested that the depressing pha-s of periodical activity of the HVM neuron might probably result from the inhibitory action in certain neuronal circuit, rather than from the intrinsic property of the recorded neurons. The effect of picrotoxin was contradictory. No periodical activity was noted in the 47 recorded neurons outside of the HVM.

Objective To analyze the multiple factors for ankylosing spondylitis(AS)patients developing hip joint disease. Methods One hundred and two patients with AS complicated with hip joint damage (group A)were compared with 54 patients with AS without hip joint disease(group B). A univariate and multivariate unconditional-Logistic regression analysis was carried. Results The mean age at the time of disease onset was(17±8)years old in group A and(24±7)years in group B(P＜0.05). The course of disease onset was(5±4)years old in group A and(11±5)years in group B(P＜0.05). The childhood of disease onset was 37.3% in group A and 20.4% in group B(P＜0.05). The patients who had hip pain at the disease onset was 38.2% in group A and 25.9% in group B(P＜0.05).The incidence of peripheral arthritis was 39.2% and 20.4%(P＜0.05)in patients of group A and group B respectively. Laboratory and X-ray findings showed that ESR, CRP, IgG and IgM levels were higher in group A than those in group B. SASP and thalidomide dosage taken in group A was lower than that in group B(P＜0.01), the dosage of prednisone taken was higher in group A than in group B. A multivariate unconditional logistic regression analysis showed 5 factors, including the younger age of the time of disease onset, the short disease duration, the childhood of disease onset and hip joint involvement at the onset were associated with the occurrence of hip joint involvement. Conclusion The younger age, childhood and hip joint involvement at the time of disease onset, short disease duration may be the risk factors and SASP may be the protecting factor for patients developing hip joint lesion. More cases and factors analysis may be helpful to predict hip joint lesion in AS and to reduce the prevalence of disability.

Objective To explore the TCM syndrome of IgAN, and formulate standard scheme on differentiation of symptoms and sings. Methods Adopted epidemiological investigation of TCM syndrome, and analyzed the relativity of clinic and pathology with the TCM syndrome. Results Two schemes of TCM showed that the qiyinliangxu syndrome was primary pattern of IgAN. The TCM syndrome showed changes of single syndrome (qiyinliangxu) → bideminy syndrome (qiyinliangxu accompanied shenluoyubi or fengshineirao)→ trigeminy syndrome (qiyinliangxu accompanied shenluoyubi and fengshineirao) with the aggravation of IgAN.Conclusions The New Scheme was more predominant in differentiation of symptoms and sings than The Old Scheme, and The New Scheme was more easy to operat and master. It was worthy to spread and utilize The New Scheme in clinic.

[Objective]To discuss the clinical experiences and unique views of professor CHEN Hongyu in treating chronic kidney disease at the fifth stage (non-dialysis).[Method]To analyze the professor CHEN Hongyu's understanding about the pathogenesis of chronic kidney disease and her academic point of view that treating from spleen and kidney. To sum up the clinical experiences in treating CKD5 (non-dialysis) according to invigorating the spleen and kidney, and analyze typical clinical case. [Result] Professor CHEN Hongyu considers that the root cause of CKD is the spleen and kidney deficiency and often accompanied by pathogenic dampness or blood stasis or turbidity toxin. Also rheumatic is an important risk factor for prompting disease activity and protracted course, which is easy to cause kidney deficiency, renal bi and is usually poor for the prognosis. Professor CHEN Hongyu considers protecting spleen and stomach and invigorating the spleen and kidney as the fundamental law, making good use of application of modern technology, emphasizing the combination of macro and micro, treatment based on syndrome differentiation,which has obvious curative effect to remit or eliminate clinical symptoms in patients with chronic renal disease, beneficial to delay the progress of the renal function and improve life quality.[Conclusion] Professor CHEN Hongyu 's experience in treating chronic kidney disease fifth stage(non-dialysis) is worth learning and spreading.

Objective Taking medical cases in Lin Zheng Zhi Nan Yi An Shi as examples to analyze the network relationship between the syndromes and prescriptions through building a medical case model forecasting medication via artificial neural networks for the syndromes and prescriptions in medical cases. Methods The study screened medical cases in Lin Zheng Zhi Nan Yi An Shi, and standardized and entered the data with Python language programming. PyBrain module was used to build and train a network model. The MatPlotLib module drew the error curve and the predicted fit curve, and evaluated the sensitivity and specificity. NetworkX module realized the visual expression of the network relationship between the syndromes and prescriptions, and analyzed the medicine within the prescriptions and compatibility relationship and the relationship between the pathogenesis and pathology. Results The sensitivity of the constructed medical case network model was 96.15% and the specificity was 75.00%. The visual mapping of the network relationship between the syndromes and prescriptions and the analysis on single, single group, and multi-angle were realized. Conclusion Neural network is capable to simulate the relationship between syndromes and prescriptions of medical knowledge. The visual combination and manifestation of network can provide a feasible solution for the knowledge discovery in medical literature.

Objective]To summarize professor SHEN Hong’s clinical experience in treating ulcerative colitis with enema prescription.[Method] By following the teacher clinic and sorting out the related cases, the author summarizes professor SHEN Hong’s academic experience of treatment of ulcerative colitis with enema prescription, and for proven cases. [Result]On the base of disease stage, Professor SHEN Hong uses the advantages of external therapy of Chinese medicine, and combines the syndrome differentiation and disease differentiation by the reference to the treatment of abscess,carbuncle. On the acute stage, he uses the elimination method to relieve heat and toxic material, cool blood and eliminate carbuncle. On the remission stage, he uses reinforcing method to support sore and drainage of pus and heal wound and promote tissue regeneration in case of recrudescence. Meantime, he focuses on the different locations of lesions by reasonable enema ways. The medication he uses is concise and the prescription changes flexibly with permitted addition and subtraction. The clinical curative effect is satisfactory. [Conclusion] Professor SHEN Hong’s experience is effective and worthy of inheritance and promotion.