Objective To explore the variation of serum levels of FT3,FT4,TSH,T3 and T4,the diagnose accordance rate of several indices in assessing thyroid function and its clinical significance.Methods Sixty patients with hyperthyrosis,ten patients with hypothyrosis(disease group)and 50 healthy people(healthy control group)were enrolled in the investigation.Chemiluminescent immunoassay(CLIA)was applied to measuring the contents of FT3,FT4,TSH,T3 and T4,and then the result correlation was compared and analyzed.Results There were statistical differences of serum levels of FT3,FT4,TSH,T3 and T4 between disease group and healthy control group(P＜0.05);while there wasn't significant difference of diagnose accordance rate for combined detection of FT3,FT4,TSH,T3 and T4 between disease group and healthy control group(P＞0.05).Conclusion Combined detection of FT3,FT4,TSH,T3 and T4 plays an important role in the early diagnosis,differential diagnosis and prognosis evaluation.It may guide the rational administration,as well as raise of healing rate and improvement rate.

OBJECTIVE:To perfect public participation system of food and drug safety in China and establish“society multi-governance”of food and drug safety. METHODS:The problems of public participation in food and drug safety administration were analyzed in China. Referring to the experience of USA,Japan,South Korea and other developed countries in stage of food and drug safety legislative decision-making,regulation and enforcement and dispute settlement,the countermeasures were put forward to perfect public participation system of food and drug safety. RESULTS & CONCLUSIONS:The public is in a passive position and shows weak right of speech in legislative decision-making stage;the public is not active and shows weak awareness of partici-pating in management in regulation and enforcement stage;public interest litigation system in dispute settlement stage has not been established. Those problems impede the generation of“society multi-governance”of food and drug safety in China. In United States,Japan,South Korea and other developed countries,the position and right of the public participation can be guaranteed com-pletely through establishing complete legal system,strengthening government information transparency,improving complaints sys-tem and public interest litigation system,etc. Our country can perfect the system of public participation in the food and drug safety and promote the generation of“society multi-governance”of food and drug safety by detailing the regulations in legislative deci-sion-making,emphasizing the information opening and feedback,strengthening the propaganda of public responsibility conscious-ness,setting up scientific food and drug safety complaint and reparting system and establishing public interest litigation system.

Fifty systems of dural venous sinuses of the Chinese people were investigated with the purpose to clarify their anatomical patterns of confluence. Four types of patterns were classified.In the first type,“simple confluence” (22%),the superior longitudinal and rectal sinuses met in the mid-line to form a typical sinus confluence,from which the two transverse sinuses arose.In the second type,“double bifurcation”(26%),both the superior longitudinal and rectal sinuses bifurcated with the union of the right and left branches to form the corres- ponding transverse sinuses.In the third type,“rectal sinus deviation”(20%), the rectal sinus deviated to one side of the transverse sinus,while the superior longitudinal sinus bifurcated.In the fourth type,“superior longitudinal sinus deviation”(32%),the superior longitudinal sinus turned to one side of the trans- verse sinus,while the rectal sinus bifurcated or opened in one side of the trans- verse sinus. The third and fourth types were subdivided into 2 subtypes respectively,i.e., the rectal sinus turned to left(18%)and the rectal turned to right(2%)for the third;the superior longitudinal sinus turned to right(30%)and the superior longitudinal sinus turned to left(2%)transverse sinus for the fourth. The cross-sectional areas of superior longitudinal,rectal,right and left trans- verse sinuses were measured in 50 systems in order to find out the capacity of these sinuses.The capacities of both transverse sinuses of each system were com- pared.In 22%,the size of the right transverse sinuses was larger than that of the left one,while in 14%,the reverse obtained.Twenty per cent showed that the size of the right transverse sinuses,was three times larger than that of the left one,while 20% showed the contrary pattern only. The occipital sinus was studied in 44 specimens.It was noted that the occi- pital sinus was present as a single vessel or in the form of 2-4 branches.In 21 specimens occipital sinuses were measured more than 1mm,of these,3 sinus were 4-6mm in cross-section.The latter might play the role of collateral branches of the transverse sinus.

Objective To compare the clinical effects between simple debridement and debridement and interbody fusion and internal fixation for the treatment of children with spinal tuberculosis.Methods 120 cases of children with spinal tuberculosis,were divided into control group(n =60)and observation group(n =60)according to surgical treatment.The control group was administrated with conventional simple debridement treatment,the observation group was administrated with debridement and interbody fusion and internal fixation,the efficacy and quality of life level of two groups of children were compared after treatment.Results The total effective rate of the observation group was 93.3%,which was significantly higher than 73.3% of the control group(χ2 =7.69,P <0.01);The blood loss,operative time,postoperative complication rate of the observation group were (83.47 ±16.35)mL,(35.38 ± 12.34)min and 6.7%,respectively;which in the control group were (165.12 ±22.31)mL,(62.15 ±21.63)min and 21.7% respectively,the difference were statistically significant(t =19.95,20.34,χ2 =8.17,all P <0.05).The adverse reactions(loss of appetite,pain in the spine)rate of the observation group was 8.3%,which was significantly lower than 30.0% of the control group(χ2 =9.02,P <0.05).Conclusion The comparison with conventional simple debridement therapy,the use of debridement over interbody fusion and internal fixation is effective on treatment in children of spinal tuberculosis,children can speed up the recovery with fewer complications,which should be widely applied.

Objective:Evaluate the role of video-assisted thoracic surgery (VATS) in the treatment of bilateral synchronous multiple primary lung cancers.Methods and Results:Two paitents diagnosised as bilateral synchronous multiple primary lung cancers received one-stage treatment combined conventional thoracotomy with video-assisted thoracic surgery,performing open lobectomy to remove the larger tumor,performing wedge resection using thoracoscopy to excise the smaller one.The surgery time is short.Patients all recover smoothly without complications.To date,these two patients all alive without any sign of recurrence or metastasis of tumor,median follow-up time is 5 months (2 months+8 months).Conclusions:It is feasible to carry out one-stage treatment combined conventional thoracotomy with video-assisted thoracic surgery on patients with bilateral synchronous multiple prima-ry lung cancers,when one of the tumors of bilateral synchronous multiple primary lung cancers is classificated as T1N0M0.

Serum pepsinogen(PG)is an effective marker for evaluating gastric mucosa function and can be used as a supplement for screening and early diagnosis of gastric cancer. Recently,serum PG has become a hot spot of study in portal hypertensive gastropathy and functional dyspepsia. Serum PG detection is a noninvasive,simple and low cost investigation method with marked clinical value. This article reviewed the value of serum PG detection in warning gastric cancer and evaluating gastric mucosa function.

Objective To explore the feasibility and advantage of the small figure-L unilateral transternal incision for the treatment of anteri or mediastinal tumor. Methods Twenty-four patients with anteri or mediastinal tumor were enrolled in the study. Under general anesthesia, after a 6 to 10 cm midline skin incision was made, a unilateral figure-L partial ste rnotomy on the side occupied by the tumor was made in the second or third interc ostals space, taking into account the tumor size and location. Tumors were resec ted with excellent exposure. Results All tumors were completely resected during the operation. In 8 cases, tumors encroached on the adjacent lu ng tissue, and lung tissue was partially resected. In 6 cases, tumors invaded th e pericardium, and the pericardium was partially removed. Mean operating time wa s 106 minutes (80~125 minutes). The mean time of hospital stay was 5 days after the operation, and there was no complication. All patients were alive with a mea n follow-up period of 14 months (3~24 months). Conclusion The figure-L unilateral mini-sternotomy is considered as an effective and useful mi nimally invasive approach for anterior mediastinal tumors.

Objective To develop a rapid method based on ARMS, named four primers allele-specific PCR(4p-AS PCR), to detect the most common non-deletional ?-thalassemia mutation Hb Constant Spring(Hb CS) by PCR technique. Methods The 4p-ASPCR was used to detect the Hb CS mutation of ?-thalassemia in 38 DNA samples of Hb H disease patients and using PCR-RE and DNA sequencing to confirm the results. Results Among the 38 Hb H disease patients 15 cases was revealed to carry Hb CS, 16 cases were deletional Hb H, and 7 cases need to be defined.Conclusion A simple, rapid and reliable method, named 4P-ASPCR, to detect Hb CS mutation have been developed. It is also may be useful in screen other point mutations such as Hb Quong Sze.

The philosophical debate on "health" was examined based on three situations in immunology: the role of the immune system in cancer, maternal infant inheritance, and xenotransplantation. The concepts of "health" depicted by naturalism, dispositionalism inherited from naturalism, and constructivism are difficult to be well applied in the above three situations. Examining whether there is something "go wrong" in the organism on physiological and natural levels, and whether the occurrence of "wrong-goings" can bring "good" results, and then giving value judgments based on them, is a better approach to characterize "health". Conducting value judgments means arousing the imagination and expectation: there is a tension between the expectation that "health can be restored" through medical intervention and the inevitable uncertainty of actual medical knowledge. If expectation failed, patients’ well-being would be undermined. Therefore, in the clinical application and research of cutting-edge methods such as immunotherapy, it is still required to be cautious about statements such as "restoring health" that may bring excessive expectations to patients.

Background:Hepatic veno-occlusive disease( HVOD) is a disease characterized by hepatomegaly,jaundice, ascites,weight gain and lack of effective treatment currently. Our prophase research showed that ligustrazine had therapeutic effect on Sedum aizoon induced HVOD in mice. Aims:To investigate the mechanism of therapeutic effect of ligustrazine on Sedum aizoon induced HVOD in mice. Methods:A total of 115 mice were randomly divided into 4 groups:mice in group A were intragastrically administrated with 30 mg·kg-1 ·d-1 Sedum aizoon to induce HVOD and served as model group;mice in group B were given 30 mg·kg-1 ·d-1 Sedum aizoon + 100 mg·kg-1 ·d-1 ligustrazine and served as low dose ligustrazine intervention group;mice in group C were given 30 mg·kg-1 ·d-1 Sedum aizoon + 200 mg·kg-1 ·d-1 ligustrazine and served as high dose ligustrazine intervention group;mice in group D were given 30 mg·kg-1 ·d-1 PBS and served as normal control group. After 30 days,all the mice were sacrificed. HE staining and Masson staining were performed for histological examination. The mRNA and protein expressions of tissue factor(TF),nuclear factor(NF)-κBp65 and early growth response factor( Egr)-1 in liver tissue were determined by RT-PCR and Western blotting, respectively. Results:HE staining and Masson staining histological examination showed that ligustrazine could obviously ameliorate the pathological injury of liver tissue in HVOD mice. Compared with group D,the mRNA and protein expressions of TF,NF-κBp65,Egr-1 were significantly increased in group A( P < 0. 05). After intervention with ligustrazine,the mRNA and protein expressions of TF,NF-κBp65,Egr-1 were significantly decreased( P < 0. 05), especially in group C,and no significant differences were found between group C and group D(P > 0. 05). Conclusions:Ligustrazine has therapeutic effect on HVOD,the possible mechanism is that ligustrazine could interrupt the activation of coagulation system by reducing the expression of TF via down regulating the expressions of NF-κBp65 and Egr-1,especially in high dose ligustrazine group.