1.Challenges and countermeasures for reproductive health of migrant population in communities
Hongyan SHOU ; Zhefang XU ; Zhenglian LIU
Chinese Journal of Hospital Administration 2010;26(10):754-756
Acceleration of social and economic growth in China is raising China's migrant population to 160 million in 2010.Their reproductive health has a close bearing on the overall national quality of the Chinese people.This reveals the significance of studying the health status for continuous improvement of such a population in China.This study is based in communities to review the challenges faced in reproductive health of migrant population,with five recommendations for upgrading quality reproductive health in communities.
2.Effect of SNP-induced hypotension on gastric intramucosal pH
Xurzhong XU ; Xutong ZHANG ; Hongyan SHOU
Chinese Journal of Anesthesiology 1996;0(08):-
Objective To assess the effect of sodium nitroprusside (SNP)-induced hypotension on gastric intramucosal pH (pHi), gastric intramucosal PCO2 ( PgCO2 ) and the difference between PgCO2 and PaCO2 (PgCO2-PaCO2) .Methods Fifteen ASA I patients (11 male, 4 female) aged 22-43 yr8, weighing 51-68 kg undergoing laminectomy for decompression of spinal cord in prone position were enrolled in this study. The patients were intubated and mechanically ventilated with 100% O2 after induction of general anesthesia. Anesthesia was maintained with isoflurane (1.2-1.4%) . Radial artery was cannulated for BP monitoring and boood sampling. TRIP tonometry catheter 14 F was inserted into stomach and connected to Tonocap ( Datex-Ohmeda, Finland) . Controlled hypotension was induced with SNP infusion at 1-5 ?g kg-1 min-1 . MAP was reduced to (60 ?5) mm Hg in 5-7 min and maintained for 60 min. Blood samples were taken before induced hypotension (T, ) , at 30 min (T2 ) and 60 min of hypotension (T3) and 30 min after hypotension (T4) for blood gas analysis. pHi, PgCO2 -PaCO2 and PETCO2 were also determined.Results MAP decreased by 35% and 33% at T2 and T3 as compared with the baseline (T, ) . pHi decreased significantly and PgCO2, PgCO2-PaCO2 increased significantly at T, as compared with those at T( ( P 0.05). pH at T2 ,T3 and T4 and BE at T3 and T4 were significantly lower than the baseline value (T1). PaCO2 and PET CO2 were significantly higher at T4 than those at T, (P
3.Strategy of hospital logistics support to the battle against COVID-19 by a hospital
Changgui CHEN ; Junfang XUAN ; Xiaohua HUANG ; Hongyan SHOU ; Jinhong FU ; Gongyi WANG ; Zhaobin CAI
Chinese Journal of Hospital Administration 2020;36(4):341-344
Public hospitals in the face of COVID-19, should prioritize medical services of patients as the topmost task. In order to ensure the smooth progress of diagnosis and treatment, and prevent the occurrence of nosocomial infection, the hospital took an overall response strategy featuring " logistics support mode 3+ 1" . This strategy requires to make facilities ready by transforming isolation wards, overall management and deployment of protection supplies, optimizing logistics service flow, strict sterilization and isolation of medical wastes and environment, optimizing catering service within the hospital to reduce the gathering and flow of personnel. It also enhanced personnel training, to eliminate staff panic and to stabilize the logistics support team. Meanwhile, the logistics department took over the hospital access screening work for tight access control, which maximize the safety and reliability of the logistics support within the hospital, and ensure the smooth progress of the epidemic prevention work.
4. Strategy of hospital logistic support to the battle against novel coronavirus pneumonia
Changgui CHEN ; Junfang XUAN ; Xiaohua HUANG ; Hongyan SHOU ; Jinhong FU ; Gongyi WANG ; Zhaobin CAI
Chinese Journal of Hospital Administration 2020;36(0):E002-E002
Nowadays hospitals have been at the forefront fighting against novel coronavirus pneumonia, with diagnosing and treating of patients as a top priority. In order to ensure the smooth progress of diagnosis and treatment, and prevent the occurrence of nosocomial infection, logistics support needs to make allowances for the isolation ward in time from the perspectives of logistics, facilities and equipment, and to transform the in-and-out double channels of ward access as required, thus setting up the partition of the three zones. Secondly, logistics support needs to optimize the logistics service workflow, including the medical waste management, the environmental disinfection isolation, and to optimize the catering service within hospitals to reduce the gathering and flow of personnel. Thirdly, logistics support needs to increase personnel training, and to eliminate psychological panic as well as to stabilize the logistics support team by putting logistics management cadres on the front line. Meanwhile, the logistics department needs to take over the hospital access screening work, strictly manage those who enter the hospital, maximize the safety and reliability of the logistics support within the hospital, and ensure the smooth progress of the epidemic prevention work.
5.Long-term hypomethylating agents in patients with myelodysplastic syndromes: a multi-center retrospective study
Xiaozhen LIU ; Shujuan ZHOU ; Jian HUANG ; Caifang ZHAO ; Lingxu JIANG ; Yudi ZHANG ; Chen MEI ; Liya MA ; Xinping ZHOU ; Yanping SHAO ; Gongqiang WU ; Xibin XIAO ; Rongxin YAO ; Xiaohong DU ; Tonglin HU ; Shenxian QIAN ; Yuan LI ; Xuefen YAN ; Li HUANG ; Manling WANG ; Jiaping FU ; Lihong SHOU ; Wenhua JIANG ; Weimei JIN ; Linjie LI ; Jing LE ; Wenji LUO ; Yun ZHANG ; Xiujie ZHOU ; Hao ZHANG ; Xianghua LANG ; Mei ZHOU ; Jie JIN ; Huifang JIANG ; Jin ZHANG ; Guifang OUYANG ; Hongyan TONG
Chinese Journal of Hematology 2024;45(8):738-747
Objective:To evaluate the efficacy and safety of hypomethylating agents (HMA) in patients with myelodysplastic syndromes (MDS) .Methods:A total of 409 MDS patients from 45 hospitals in Zhejiang province who received at least four consecutive cycles of HMA monotherapy as initial therapy were enrolled to evaluate the efficacy and safety of HMA. Mann-Whitney U or Chi-square tests were used to compare the differences in the clinical data. Logistic regression and Cox regression were used to analyze the factors affecting efficacy and survival. Kaplan-Meier was used for survival analysis. Results:Patients received HMA treatment for a median of 6 cycles (range, 4-25 cycles) . The complete remission (CR) rate was 33.98% and the overall response rate (ORR) was 77.02%. Multivariate analysis revealed that complex karyotype ( P=0.02, OR=0.39, 95% CI 0.18-0.84) was an independent favorable factor for CR rate. TP53 mutation ( P=0.02, OR=0.22, 95% CI 0.06-0.77) was a predictive factor for a higher ORR. The median OS for the HMA-treated patients was 25.67 (95% CI 21.14-30.19) months. HMA response ( P=0.036, HR=0.47, 95% CI 0.23-0.95) was an independent favorable prognostic factor, whereas complex karyotype ( P=0.024, HR=2.14, 95% CI 1.10-4.15) , leukemia transformation ( P<0.001, HR=2.839, 95% CI 1.64-4.92) , and TP53 mutation ( P=0.012, HR=2.19, 95% CI 1.19-4.07) were independent adverse prognostic factors. There was no significant difference in efficacy and survival between the reduced and standard doses of HMA. The CR rate and ORR of MDS patients treated with decitabine and azacitidine were not significantly different. The median OS of patients treated with decitabine was longer compared with that of patients treated with azacitidine (29.53 months vs 20.17 months, P=0.007) . The incidence of bone marrow suppression and pneumonia in the decitabine group was higher compared with that in the azacitidine group. Conclusion:Continuous and regular use of appropriate doses of hypomethylating agents may benefit MDS patients to the greatest extent if it is tolerated.