Objective To evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) with 355～500?m polyvinyl alcohol (PVA) particles for treatment of larger hepatocellular carcinoma (HCC). Methods Seventy-three patients with larger HCC had been undergone TACE. Median tumor size was 12.3 (range 8.4～20.4) cm with Child-Pugh class A in all patients. The chemotherapy agents, Lipiodol and PVA were injected into tumor artery for each patient, with dose of PVA 100mg for 71 patients, 200mg and 50mg for each of another cases, respectively. The changes and responses of liver function and tumor size were noted. Results The tumor size decreased with an average of 3cm (P

For interventional therapy of hepatic carcinoma, the anatomical pathway and the variation of complex vessels often cause difficulties in performing super-selective catheterization, or even result in catheterization failure. Understanding of the vascular variations and finding out the effective technique of catheterization can surely reduce the radiation exposure dose to both the operators and patients, and in the same time, can increase the successful rate of super-selective catheterization, which will undoubtedly improve the curative effect. More than 30 thousand times of interventional managements for hepatic carcinoma have been performed in our hospital, from which the author has selected some successful cases as well as some unsuccessful cases to make a technical analysis in order to sum up the experience of super-selective catheterization for clinical physicians' reference.

Interventional treatment has become the first-line therapeutic method for intermediate-stage hepatocellular carcinoma (HCC). With the development of related techniques,drug-loaded microparticles and radioactive microspheres have been applied in clinical prac-tice,with good therapeutic effect achieved.This paper analyzes and summarizes the existing interventional treatment methods and problems, and points out that HCC patients can achieve great benefits from combination therapy,and that standardized interventional therapy is a direc-tion for future development.

Seven cases exhibited segmental bile duct dilation with filling defects. One case only showed dilatation of lobar bile ducts. Conclusion MRI features of IPNB are helpful for distinguishing IPNB from other hepatic lesions.

Hepatocellular carcinoma (HCC) has a high fatality rate and most patients are in advanced stage when diagnosed with routine methods.As a molecular imaging method, positron emission tomography/computed tomography (PET/CT) has become more and more important.However, it also has certain limitations, since it always has false-negative results for well-differentiated HCC and small HCC.Therefore, a combination of various tracers can improve the sensitivity and specificity of PET/CT in the diagnosis of HCC.This article reviews the role of PET/CT in the therapeutic effect evaluation, recurrence monitoring, and prognosis of HCC.

Objective To evaluate the value of liver acquisition with volume acceleration(LAVA) in the diagnosis of hepatic outflow abnormalities.Methods LAVA was performed in 78 patients with suspected hepatic outflow abnormalities,thrombosis,stenosis,occlusion,or compression,including 71 hepatocellular carcinomas and 7 Budd-Chiari syndrome.Image quality and the presence of venous abnormalities and collaterals were evaluated.Results LAVA images were of diagnostic quality and without artifact in all patients.LAVA clearly showed the vascular anatomy and various disorders.The site,extent,cause of venous obstruction,and collateral pathways were well depicted.Conclusion LAVA is simple to perform and accurate in detecting hepatic outflow abnormalities.

10 mm)were showed by DSA.On nonenhanced CT,there were 3-4 low density nodules and 4 isodensity nodules.Thirty-two nodules was high density and 8 nodules was low density in arterial phase,33 and 7 nodules were low density and isodensity respectively in portal venous phase,39 and 1 nodule were low density and isodensity respectively in delayed phase.Conclusion The MSCT is excelled DSA in detection satellite nodule of HCC,especially smaller than 10 mm nodule.

Objective To improve health care workers’(HCWs)infection prevention and control consciousness through carrying out catheter-associated urinary tract infection(CAUTI)prevention and control project,and imple-ment prevention and control measures in practical work.Methods Diagnostic criteria of CAUTI issued by the U.S. Centers for Disease Prevention and Control/National Healthcare Safety Network were adopted,from October 2013 to September 2014,monitoring was conducted on CAUTI in patients with indwelling urinary catheters for >2 con-secutive days at different types of ICUs in hospitals participated in the project .Results A total of 14 124 CAUTI cases were collected,410 patients developed CAUTI,urinary catheter usage rate was 79.33%(203 114/256 042), incidence of CAUTI was 2.02‰(410/203 114),urine specimen detection rate was 46.52%(6 570 /14 124).The detection rate of urine specimens increased from 37.24% (the fourth quarter of 2013)to 49.76% (the third quarter of 2014).Of prevention measures,the difference in the indication of catheterization was significantly different(P <0.01).Conclusion Through the development of competence building project of healthcare-associated infection pre-vention and control,prevention and control of CAUTI has achieved good intervention effect.

Objective To explore the differences of blood biochemical indicators between normal and kidney Yang deficient rats administered orally different doses of white prepared lateral root of aconite.Method Eighty Sprague-Dawley(SD) male rats were divided randomly into normal group and kidney Yang deficient model group,forty rats in each group.After producing kidney Yang deficient model by injecting hydrocortisoni natrii succinas in intramuscular,normal and model rats were respectively and randomly divided into little,low,medium,great dose group and blank group,eight rats in each group.Those rats were administered orally with different concentrations of white prepared lateral root of aconite every day for two weeks.Twenty-four hours after the last oral administration,the blood were obtained and used for testing adrenocorticotrophic hormone(ACTH),cyclic adenosine monophosphate(cAMP),cyclic guanosine monophosphate(cGMP),glucose(GLU),cholesterol(CHO),alanine aminotransferase(ALT),urea nitrogen(BUN).Results Before taking medicine,model rats' cAMP/cGMP and ACTH were lower than normal rats',and they showed a trend of rise with adding dose.Before taking medicine,model rats' GLU was lower than normal rats'.With adding dose,model rats' GLU increased,however,normal rats' GLU reduced.When taken medium dose white prepared lateral root of aconite,model rats' CHO was higher than normal rats'.Taking medicine made both groups ALT rise,but normal rats' went up more quickly than model rats'.Model rats' BUN was higher than normal rats',and taking low dose or little dose medicine could lead to incline of reduction.Conclusion White prepared lateral root of aconite caused different blood biochemical effects on normal and kidney Yang deficient rats,and more remarkable toxicity effect on normal rats.

ObjectiveTo analyze the polymorphism of HLA-A,B,and DRB1 alleles and their haplotypes in Chinese Man population.Methods Frequencies of HLA-A,B and DRB1 alleles and haplotypes were estimated by maximum-likelihood estimation method based on the genotypes of 2183 Chinese Man bone marrow donors.ResultsA total of 18 HLA-A alleles,44 HLA-B alleles and 15 HLA-DRB1 alleles were detected in Man population,and the most frequent alleles were A*02,A*11,A*24,A*30,A*33,B*13,B*35,B*46,B*51,B*40(B60),B*40(B61),B*15(B62),DRB1*04,DRB1*07,DRB1*08,DRB1*09,DRB1*11,DRB1*12,DRB1*13,DRB1*14 and DRB1*15.A*30-B*13,A*02-DRB1*15,B*13-DRB1*07 and A*30-B*13-DRB1*07 were the most frequent haplotypes in Man population for A-B,A-DRB1,B-DRB1 and A-B-DRB1 haplotype,respectively.The number of haplotypes with frequency ≥ 0.01 for A-B,A-DRB1 and B-DRB1 haplotype was 31,24 and 27,respectively,and ≥ 0.005 for A-B-DRB1 haplotype was 32.There were 14 in A-B,3 in A-DRB1,14 in B-DRB1 and 38 in A-B-DRB1 haploypes that showed strong linkage disequilibrium with ALD≥0.40.ConclusionsThe distribution of HLA-A,B and DRB1 alleles and haplotypes in Man population was similar to that in Northern Chinese Han population.