1.Progress in treatment of later period non-small cell lung cancer
Cancer Research and Clinic 2007;19(z1):142-143
The lung cancer outbreak takes the first place in the global malignant tumor outbreak,becoming mainly reason to make death.Non-small cell lung cancer accounts for 80% of lung cancer around,70%~80% has already belonged to a later period while diagnosing(Ⅲ~Ⅳ period),It is the recommendation mode for later period NSCLC that the chemotherapy and radio treatment to put.The solution of using DDP/CBP with taxanens/gemcitabine/vinorelbine can raise curative effect further.It is a new way to treat later period NSCLC that is to use targeted treatment drug.
2.Effect of thalidomide combined with PC regimen on efficacy/serum VEGF in patients with non-small cell lung cancer
Li ZHUANG ; Hongxuan REN ; Qing BI
China Oncology 2001;0(02):-
0.05),but significantly between VEGF levels before(261?135 pg/ml) and after(679?175 pg/ml) treatment in control group(P
3.Navelbine plus cisplatin in the treatment of advanced non-small cell lung cancer
Hongxuan REN ; Canzhen ZHANG ; Ling ZHAO ;
China Oncology 2001;0(03):-
Purpose:To evaluate the results of combination chemotherapy with navelbine (NVB) and cisplatin (DDP) in patients with stage Ⅲ b—IV non small cell lung cancer (NSCLC), as compared with MVP regimen. Methods:16 cases were treated with MVB+DDP, 20 cases were treated with MVP. Results:The response rate was 50.0% in patients with NVB plus DDP, 40% in those treated with MVP . The major toxic reactions in the two groups were tolerable,being myelo suppression and grstrointestinal reaction. Grade Ⅱ—Ⅳ phlebitis rate was 37.5% in patients with NVB puls DDP, 0.0% in those treated with MVP, respectively ( P 0.05). Conclusions:A higher response rate is attainable with stage Ⅲ b—IV NSCLS treated by navelbine and cisplatin with tolerable toxicity. [
4.Therapy experience in NHL patients with diabetics
Lida SHEN ; Canzhen ZHANG ; Hongxuan REN ; Yunxia LI ; Mingjia DENG
Cancer Research and Clinic 2000;0(06):-
Objective Discuss therapy problems in NHL patients with diabetics. Methods 40 NHL patients with diabetics are treated with chemotherapy containing prednisone. Compare the blood sugar before using prednisone with the one after that, regulate medicines of reducing glucose and at the same time observe the syndromes. Results Limosis blood sugar of patients just in hospital is (6.1?1.3) mmol/L, and after chemotherapy it becomes (6.5?1.2) mmol/L. There is no significant difference between them. Conclusions On the basis of controlling blood sugar effectively, patients with NHL combining diabetics can use prednisone as normal.
5.Psychosocial factors and lung cancer development.
Canzhen ZHANG ; Lida SHEN ; Yufeng WANG ; Hongxuan REN ; Yunxia LI ; Lin ZHAO ; Jigao HE
Chinese Journal of Lung Cancer 2002;5(2):92-94
BACKGROUNDTo study the association between psychosocial factors and the development of lung cancer.
METHODSCase-control matched study was employed in the study. A standardized life event, social support and defense mechanisms interview was administered respectively. Total 118 lung cancer patients who were diagnosed pathologically were chosen as case group, and 118 matched healthy people were as control group. The pair had the same gender, the same race, and the same occupation, and lived in the same area, and the age difference between the two groups was ±3 years.
RESULTSUnivariate analysis showed that smoking, defect of sleeping, alcohol consuming, smoking and drinking during meal, preserved food consuming, irregularity of life increased the risk of lung cancer development (P < 0.05). The scores of life events, social support had no significant difference between two groups (P > 0.05), but the scores of stress life events was higher in cancer group than that in control group. The immature factors of defense mechanisms in cancer group were higher than those in control group (P < 0.05). Multiple qualified logistic regression showed that smoking and defect of sleeping were the main risk factors of lung cancer genesis.
CONCLUSIONSThere is certain association between psychosocial factors and lung cancer development. The immature defensive factor is the psychosocial factor of lung cancer genesis, and smoking, defect of sleeping, alcohol consuming, smoking and drinking during meal, preserved food consuming, irregularity of life are the risk factors of lung cancer.