OBJECTIVE:To compare the clinical efficacy and safety of Shexiang baoxin pills and Shensong yangsin capsules in the treatment of coronary heart disease complicated with chronic heart failure and premature ventricular contractions. METHODS:129 patients with chronic heart failure and premature ventricular contractions were randomly divided into blank group(n=43),ob-servation group(n=43)and control group(n=43). All groups received routine treatment as oxygen inhalation,diuretics. Control group additionally received Shensong yangsin capsules 4 pills for 3 times per day. Observation group additionally received Shexiang baoxin pills 2 pills for 3 times per day. Treatment course of 2 groups lasted for 3 months. Clinical efficacies of 2 groups were ob-served,and heart function,cardiovascular autonomic nervous function and vascular endothelial function were observed before and after treatment. RESULTS:Total effective rate of observation group was significantly higher than that of control group(P<0.05). SDNN,SDANN,RMSSD,QTd was no statistical significance between control group and observation group(P>0.05). LVEF, NO of observation group were significantly higher than that of control group(P<0.05),IVST,LVDd,LVPWT,ET of observation group were significantly lower than that of control group(P<0.05). But control group and observation group were better than the blank group,and no obvious adverse reaction. CONCLUSIONS:Shexiang baoxin pills is more effective than Shensong yangsin cap-sules in the treatment of coronary heart disease complicated with chronic heart failure and premature ventricular contractions.

OBJECTIVE:To observe the clinical efficacy and safety of Mailuoning injection in the treatment of acute bronchial asthma. METHODS:92 patients with acute bronchial asthma were randomly divided into control group and observation group. Pa-tients in control groups were received routine treatment,including oxygen inhalation,glucocorticoid,β2 agonists,aminophylline and anti-infection,etc. Patients in observation group were added Mailuoning injection 20 ml adding into 5% glucose injection or 0.9% sodium chloride injection 500 ml by intravenous infusion,once a day,based on the treatment of control group. The course was 14 d. The clinical data was observed,including clinical efficacy,hemorheology indicators,pulmonary function,6-keto-PGF1αlevel and incidence of adverse reactions before and after treatment. RESULTS:The total effective rate in observation group was sig-nificantly higher than control group,with significant difference(P<0.05). After treatment,the hemorheology indicators,lung func-tion indicators and 6-keto-PGF1α level in 2 groups were significantly better than before,and observation group was better than con-trol group,with significant difference(P<0.05). There were no obvious adverse reactions. CONCLUSIONS:Routine treatment combined with Mailuoning injection can effectively improve the efficacy of acute bronchial asthma with good safety.

Cancer cachexia is a common syndrome in advanced cancer patients.It is the interactive re-sult between tissue of tumor and organism.Tissue of tumor affects organism by producing cytokines and special tumor agents,meanwhile the reaction of acute phase and aeuroendocrine reaction happen in all over the body.Age,physical activity level and abnormal metabolism of muscle protein of patients are also correlated to cancer cachexia.Now clinical strategy to cancer cachexia is to improve symptoms of patients,such as anorexia,and So on.Along with elucidating the nosogenesis of cancer cachexia,the research of drugs having identified targets becomes focus.

OBJECTIVE:To observe the efficacy and safety of Children resuqing oral lipid in the treatment of acute suppurative tonsillitis. METHODS:112 children with acute suppurative tonsillitis were randomly divided into control group and observation group. Control group was treated with Amoxicillin clavulanate potassium for injection 30 mg/kg,twice a day;based on the treat-ment of control group,observation group was treated with Children resuqing oral lipid,1/4-1/2 bag for <1 year old,1/2-1 bag for 1-3 year(s)old,1-1.5 bag(s)for 3-7 years old,1.5-2 bags for 7-12 years old,3-4 times a day. The treatment course was 5 d. The clinic data was observed,including clinical efficacy,average cooling time and throat disappear time,WBC,CRP level,and CD4+/CD3+,CD4+/CD8+and CD8+/CD3+in vivo before and after treatment and incidence of adverse reactions in 2 groups. RESULTS:The to-tal effective rate in observation group was significantly higher than control group,average cooling time and throat disappear time were significantly shorter than control group(P<0.05). After treatment,WBC and CRP level were significantly lower than before, and observation group was lower than control group;CD4+/CD3+ was significantly higher than before,and observation group was higher than control group;CD4+/CD8+in observation group was significantly higher than before and control group,CD8+/CD3+in con-trol group was significantly higher than before(P<0.05);however,there were no significant differences in the CD8+/CD3+ in obser-vation group before and after treatment,and incidence of adverse reactions between 2 groups (P>0.05). CONCLUSIONS:Based on the treatment of Amoxicillin clavulanate potassium for injection,Children resuqing oral lipid has better efficacy and safety in the treatment of acute suppurative tonsillitis.

Objective To observe the influence of Wenxin Capsules on mean platelet volume (MPV) and platelet distribution width (PDW) in rats with coronary heart disease classified as heart-yang deficiency.Methods Rat model with coronary heart disease classified as heart-yang deficiency were established by gavage of high fat diet,subcutaneous injection of pitutrin and cold stimulation. Effects of Wenxin Capsules on the morphology of MPV and PDW were observed. Results MPV and PDW were decreased in Wenxin Capsules group (P

AIM:To study the effects of isoproterenol (Iso) on cardiac fibrosis and related cytokines in rats. METHODS:20 SD rats were divided into control and Iso group in random, with 10 rats each group. After injected Iso, cardiac histology was observed and cardiac function, collagen volume fraction (CVF), content of collagen protein and the concentrations of Angiotensin Ⅱ (Angll) and nitrogen monoxide (NO) were measured in the two groups. RESULTS:Compared with control group, microscopic examination showed that fibrosis increased in Iso group. Iso did decrease cardiac function and NO levels and increase CVF, content of collagen protein and AngII levels. Left ventricular pressure maximal rate of rise (+ dp/dt_(max)) and left ventricular systolic pressure (LVSP) were not significantly different from that of control group. CONCLUSIONS:Iso can induce myocardial fibrosis and change levels of related cytokines in rats.

Objective To compare the early curative effects of arthroscopic modified suture bridge and single-row modified Mason-Allen suture in repair of supraspinatus tendon tears.Methods A retrospective case-control analysis was made on 28 patients with supraspinatus tendon tears admitted between June 2012 and June 2015.There were 16 males and 12 females,aged 43-63 years (mean,54.2 years).Thirteen patients (13 shoulders) were repaired using the arthroscopic modified suture bridge technique (Group A),and 15 patients (15 shoulders) were treated using the single-row modified Mason-Allen technique (Group B).Operation time and intraoperative blood loss were recorded.American shoulder and elbow surgeons (ASES) score,Constant score and visual analogue score (VAS) were used to evaluate the function and subjective outcomes preoperatively.Meanwhile,MRI was used for analysis of tendon integrity postoperatively.Results The operation time of Group A and B were (56.1 ± 23.2) minutes and (36.1 ± 15.6) minutes,respectively (P ＜ 0.05).The intraoperative blood loss was (30.3 ± 20.5) ml and (28.5 ± 18.2) ml,respectively (P ＞ 0.05).The average follow-up time for Groups A and B were 12 months and 12.6 months,respectively.The symptoms of 28 cases were alleviated after surgery,and the functions were obviously recovered.In Group A,thc VAS was decreased significantly from (7.0 ± 0.8) points preoperatively to (0.8 ± 0.8) points at final follow-up,ASES score was improved from (39.8 ± 3.1) points to (88.1 ± 4.8) points,and Constant score was improved from (54.8 ± 2.7) points to (88.2 ± 3.1) points (all P ＜ 0.05).In Group B,the VAS was decreased significantly from (6.8 ± 0.8) points preoperatively to (0.9 ± 0.8) points at final follow-up,ASES score was improved from (40.7 ± 2.5) points to (89.5 ± 3.2) points,and Constant score was improved from (56.0 ± 4.5) points to (89.3 ± 3.4) points (all P ＜ 0.05).There was no significant difference in the clinical outcomes between the two groups (P ＞ 0.05).The retear rate in Group B was 20％ (3/15),while no retear was presented in Group A (P ＜ 0.05).Conclusion Arthroscopic modified suture bridge technique and single-row modified Mason-Allen technique are both clinically effective for function recovery and pain relief in patients with supraspinatus tendon tears,but the former associated with lower incidence of tendon re-tear is preferred for moderate to large rotator cuff injury or rotator cuff injury with large insertion avulsion.

Objective: To research the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction in coronary heart disease rats with yang deficiency and blood stasis of heart.Methods: The coronary heart disease rat models were established by administering high fat diet,subcutaneous injection with pituitrin and being stimulated by cold methods.Then,to observe the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction.Results: Compared with model group,the concentration of plasma von Willebrand factor(vWF),the content of thromboxane B2(TXB2),the platelet aggregation rate,the molecular number of GPⅡb/Ⅲa and the content of platelet?granularmembrane protein(GMP 140) in Wenyang Huoxue Compound Preparation group decreased apparently(P

The scale and questionnaires were used to analyze the constituent ratio of symptoms at different stages. The relationship between the main syndrome and pathogenesis of coronary heart disease at different stages was analyzed by statistical methods and the medical principles analysis Thus the successive order of main symptoms and the transforming relations were ascertained. So basic pathogenesis and evolution rule of symptoms that penetrated the whole process of the disease were expounded: the dificiency of syndrome and emotinal factors were the key to the whole process of onset of coronary heart disease.

Objective To explore the influence from I Ching perception of febrile disease theory to the syndrome differentiation and treatment of Viral myocarditis.Methods Documentary study.Results The febrile disease theory gained certain reference from simple ontology and motion concept in ancient Chinese philosophy.VMC was caused by disorder of five evolutive phases and six climatic factors,transition from Kan diagram to Li diagram,together with the mixture of pathogenic qi.Treatment should mainly focus on eliminating pathogen and nourishing yin to coordinate water and fire,conforming to universe rules,and smoothing Qi to reduce blockage.Conclusion The cognitive perception,pathogenesis and treatment of febrile disease theory are all deeply influenced by I Ching.Therefore,the combination of I Ching and febrile disease theory in diagnosis and treatment of VCM will improve clinical effects,as well as featuring the cultural nature of Traditional Chinese Medicine.