This paper reports the results of surgical management of 38 patients with chronic gasric and duodenal ulcer complicted with mycotic infection.This disease was easily be misdiagnosed as gas- tric carcinoma,especially when a mass can be palpated in the upperabdomen.Gastroscopical biopsy was the most effective method of diagnosis.When the ulcer complicated with mild mycotic infection,it can be treated by anti-mycotic drugs.But if the ulcer is large and deep,or complicated with hemorrhage,perforation or malignancy,the treatment of choice is surgery.Before operation,using anti-mycotic drugs to prevent the occurrence of mycotic sepsis must be consider- ated.During operation,if malignancy is suspected,frozen section should be taken.

Objective:To investigate the relationship between pemphigus vulgaris(PV) and HLA-DR,DQ haplotypes in Han nations of northeast China.Methods:Polymerase chain reaction-sequence specific primers(PCR-SSP) method was used to detect the HLA-DRB1 and DQB1 alleles of 27 PV patients of Han nation of northeast China, analysed haplotyes and compared with 99 healthy controls.Results:Compared with control group, the frequencies of the haplotypes of HLA-DRB1*140x-DQB1*0503,DRB1*140x-DQB1*0201,DRB1*120x-DQB1*0503 and DRB1*140x-DQB1*0302 increased significantly in PV group. After statistical test, the difference between the two groups was significant.Conclusion:The special haplotypes may contribute to genetic susceptibility to PV in northeast Chinese.