Erythropoietin(EPO) is a main growth factor that regulates the erythropoiesis under the physiological conditions and after blood loss. At present, it is one of the special effective clinical drugs for treating anemia due to renal failure, chronic infection, AIDS, tumor and some other causes. However, its short plasma half-life makes more frequent administration, which increases the burden and pain on patients. Therefore, development of long-acting agents is a hot. Continuous erythropoietin receptor activator(CERA) is a third-generation erythropoiesis-stimulating agents(ESA). It has a largely prolonged plasma half-life and extended administration intervals, which are different from other ESAs. This review gives a detail demonstration about the development, molecular structure, biochemical characteristics and the most common adverse effects of CERA, as well as the international attention when CERA works as a doping.

Objective To explore the clinical characteristics,diagnosis and treatment of pancreatic reginal(portal) hypertension(PSPH).Methods The clinical data of 11 cases of PSPH were analysed and(summarized).Results All of the patients in this group underwent surgical operation.Postoperative(complications) occurred in 4 patients,all of whom recovered with conservative treatment.There was no(operative) mortality.Seven cases were followed up after operation;one patient died from cancer of the pancreas three years after operation;in other six cases,no massive digestive tract re-bleeding occurred,and symptoms of hypersplenism disappeared completely.Conclusions PSPH is a special type of portal hypertension,surgical treatment can get excellent results.

Objective:To investigate the reason for the adhesion of vocal cord after CO_2 Laser laryngeal surgery.Method:One hundred and nineteen patients who were untaken CO_2 Laser laryngeal microsurgery.Result: Among 119 cases,9 cases of bilateral vocal cord paralysis, 42 cases of vocal cord polyps and 3 cases of precancerous laryngeal lesions did not show vocal cord adhesion after CO_2 Laser laryngeal microsurgery.Contrarily, one of 5 cases with laryngeal stenosis, 5 of 41 cases with laryngeal papilloma and 6 of 19 cases with laryngeal carcinoma shew the adhesion of vocal cord after CO_2 Laser laryngeal microsurgery.Conclusion:Through selecting the appropriate patient and surgery spot, processing correctly during and after surgery, using the suitable dosage of laser and reducing the heat radiation, the adhesion of vocal cord can be avoided after CO_2 Laser laryngeal surgery.

A new method for the simulation of the mass distribution of cancellous bone is presented on the basis of finite element analysis (FEA). In this method,the process of bone remodelling is considered as a process of the topology optimization of a corresponding continuum structure. Fabric tensor is used to express the microstructure and the constitutive properties of cancellous bone. The effective volume fraction or the relative density of a point in the design domain is expressed by the invariables of the fabric tensor. A reference strain interval, which is corresponding to the strain dead zone of a bone in biomechanics, is applied to detect the the final topology of the structure. By the present approach, several numerical results are given, i. e., the simulation on the shape of the coronal plane of vertebrae, the predictions of the mass distributions of the two-dimensional and the three-dimensional proximal femurs. The validity and feasibility of this new method are verified by the comparison between the results of the present work and those in the published literatures.
Adaptation, Physiological ; Algorithms ; Biomechanical Phenomena ; Bone Density ; physiology ; Bone Remodeling ; physiology ; Bone and Bones ; physiology ; Computer Simulation ; Femur Head ; physiology ; Finite Element Analysis ; Humans ; Models, Biological ; Stress, Mechanical

OBJECTIVE: To investigate the reason for the adhesion of vocal cord after CO2 Laser laryngeal surgery. METHOD: One hundred and nineteen patients who were untaken CO2 Laser laryngeal microsurgery. RESULT: Among 119 cases, 9 cases of bilateral vocal cord paralysis, 42 cases of vocal cord polyps and 3 cases of precancerous laryngeal lesions did not show vocal cord adhesion after CO2 Laser laryngeal microsurgery. Contrarily, one of 5 cases with laryngeal stenosis, 5 of 41 cases with laryngeal papilloma and 6 of 19 cases with laryngeal carcinoma shew the adhesion of vocal cord after CO2 Laser laryngeal microsurgery. CONCLUSION Through selecting the appropriate patient and surgery spot, processing correctly during and after surgery, using the suitable dosage of laser and reducing the heat radiation, the adhesion of vocal cord can be avoided after CO2 Laser laryngeal surgery.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Humans ; Laryngeal Diseases ; etiology ; pathology ; Laryngeal Neoplasms ; surgery ; Lasers, Gas ; adverse effects ; Male ; Middle Aged ; Precancerous Conditions ; etiology ; Tissue Adhesions ; Treatment Outcome ; Vocal Cords ; pathology ; Young Adult

OBJECTIVE: To evaluate the position and shape of inserted electrode arrays by plain X-ray during cochlear implantation. METHOD: Cochlear view of implanted electrode arrays by plain X-ray were observed during operation in 54 patients received cochlear implant. RESULT: The image in cochlear view could provide the information about position and shape of inserted electrode arrays. The spiral-shape electrode arrays without distortion and folding were found in 52 cases. The complete insertion of intracochlear electrode in these patients were confirmed by surgery. Of 54 cases, the other 2 cases showed improper position and C-shape of intracochlear electrodes, one was partial insertion and the other was bending inside the cochlea. The bending electrode array was reinserted immediately during operation. CONCLUSION Routine plain X-ray after inserted electrode during operation was a best way of knowing the shape and depth of the electrode array, especial for the difficult cochlear implantation, and also could avoided anesthetization again.
Adolescent ; Child ; Child, Preschool ; Cochlea ; diagnostic imaging ; Cochlear Implantation ; methods ; Cochlear Implants ; Electrodes, Implanted ; Female ; Humans ; Infant ; Male ; Radiography ; X-Rays ; Young Adult

Objective:To investigate the effects of case-based learning combined with clinical anatomy in neurosurgery internships.Methods:We included students in grades 2014 and 2015 (test group, n=58) and those in grade 2013 (control group, n=48) doing internships in The first Affiliated Hospital of Shantou University Medical College. The test group adopted case-based learning combined with clinical anatomy in the form of neurosurgery intern learning groups. The group learning consisting of four sessions was held twice a week for a total of four times. The traditional teaching method was used in the control group. All the students filled in the Self-Directed Learning Readiness Scale before and after neurosurgery internships. The test group filled in the Satisfaction Survey on case-based learning combined with clinical anatomy after neurosurgery internships. SPSS 20.0 was used to perform t test. Results:Before neurosurgery internships, there was no difference in self-directed learning ability between the test group and control group ( t=0.25, P=0.807). After the internships, the total score of self-directed learning ability was significantly improved in both the test group ( t=-6.49, P<0.001) and the control group ( t=-4.68, P<0.001). The test group showed improvements in six learning factors, while the control group had no significant changes in love of learning and learning motivation. Compared with the control group, the test group showed a significantly higher total score of self-directed learning ability ( t=2.17, P=0.032) and significantly higher scores of efficient learning ( t=3.81, P=0.001) and learning motivation ( t=4.20, P=0.001). The students in the test group were generally satisfied with the new method combining case-based learning and clinical anatomy. Conclusion:The new method combining case-based learning and clinical anatomy has positive effects on students' self-directed learning ability, especially on learning efficiency and motivation, with a high degree of satisfaction from the students.

Bronchoscopy ; methods ; Female ; Glomus Tumor ; surgery ; Humans ; Male ; Middle Aged ; Tracheal Neoplasms ; surgery

Constraint-based genome-scale metabolic network models (genome-scale metabolic models, GEMs) have been widely used to predict metabolic phenotypes. In addition to stoichiometric constraints, other constraints such as enzyme availability and thermodynamic feasibility may also limit the cellular phenotype solution space. Recently, extended GEM models considering either enzymatic or thermodynamic constraints have been developed to improve model prediction accuracy. This review summarizes the recent progresses on metabolic models with multiple constraints (MCGEMs). We presented the construction methods and various applications of MCGEMs including the simulation of gene knockout, prediction of biologically feasible pathways and identification of bottleneck steps. By integrating multiple constraints in a consistent modeling framework, MCGEMs can predict the metabolic bottlenecks and key controlling and modification targets for pathway optimization more precisely, and thus may provide more reliable design results to guide metabolic engineering of industrially important microorganisms.
Genome ; Metabolic Engineering ; Metabolic Networks and Pathways/genetics* ; Models, Biological ; Thermodynamics