Objective To investigate the MRI features and pathological findings of primary intracranial lymphoma and to improve the diagnostic accuracy.Methods MRI features and pathological findings were analyzed in 28 pathologically proved cases of primary intracranial lymphoma.All 28 cases were examined by MRI scanning and diffusion weighted imaging(DWI),among which 19 cases were examined by enhanced MRI scanning.Results MRI manifestations:(1)single type:intracranial single lesion,the most common site was nearly the middle area of deep brain or brain surface;(2)multiple type.Type Ⅱa:multiple lesions in regional distribution, often showed several small lesions around a larger lesion.Type Ⅱb:multiple lesions in diffused distribution,often showed scattered distribution without an obvious regional distribution.The shapes of lesion were mass-like,nodular or irregular.The lesions showed isointense or slightly hypointense on T1 WI,and isointense,slightly hyperintense or slightly hypointense on T2 WI.On DWI,the le-sions showed hyperintense.Most lesions showed obvious enhancement with fisting sign,incision sign,pointed sign,butterfly sign,long and stiff spicule signand comb sign.Pathology:the tumor cells were heteromorphic and spread around the vessels, and showed greater cellularity,big prominent nucleoli,and small lymphocytes.The immunohistochemical examination showed that all tumor cells were positive for CD20 and CD79a and negative for GFAP.Conclusion The MRI findings of primary intracranial lym-phoma are various.Careful analysis can improve the diagnostic accuracy of the disease,definitive diagnosis requires histopathological and immunohistochemical examinations.

BACKGROUND:64-slice CT reconstruction technique for tibial plateau fractures hasobtainedsatisfactory results. This technology can reconstruct three-dimensional fracture relations, provide more scientific positioning and navigation standards for physicians, and improve the clinical cure rate. However, in the clinic, navigation method of 64-slice CT reconstruction techniques for tibial plateau fractures lacks a unified standard. OBJECTIVE:To study the navigation method and effect of 64-slice CT reconstruction in tibial plateau fractures. METHODS:A total of 44 patients with tibial plateau fractures were enroled in this study, including 27 males and 17 females, at the age between 21 and 74 years old. These patients were randomly divided into two groups (n=22). The control group underwent navigation method according to physician’s experience. The test group underwent navigation method according to 64-slice spiral CT scan results. Healing time, ful weight-bearing time, knee motion rangeat1 year postoperatively, the recovery ofknee functionat1 year postoperatively and adverse reaction were compared between the two groups. RESULTS AND CONCLUSION:(1) No significant differences in ful weight-bearing time and knee motion rangeat1 year postoperatively were detected between the two groups (P> 0.05). Healing time was significantly shorter in the test group than in the control group (P< 0.05). (2) The excelent and good rate of knee joint was 100% at 1 year postoperatively in the test group, which was significantly higher thanthe control group (81%) (P< 0.05). (3) The complication rate was significantly lower in the test group (8%) than in the control group (18%) (P< 0.05). (4) These results indicate that the effect of 64-slice CT reconstruction for navigation in tibial plateau fractures was ideal, could clearly simulate the pedicle screw fixation channel, visibly display anatomic characteristics of tibial plateau fractures, improve internal fixation accuracy, and improve repair effect.

Objective:To discuss the applied value of the ultrasonic light scattering imaging DOT technology in the diagnosis of early breast lumps. Methods: The data of 114 patients that were experted ultrasound imaging of light scattering and were with clear pathological diagnosis results were analyzed retrospectively in our department in three years. Diagnostic indicators (SDI), the mass of the total amount of hemoglobin (HBT), oxygen saturation (SO2), mass direction (Orien) form factor (Forml) and the posterior echo (Pecho) were recorded, and the diagnostic sensitivity, specificity, positive predictive value, negative predictive value, false negative rate and false positive rate were analyzed. The results were proceed and analyzed through SPSS 17.0. Results:There were significant differences in the SDI, HBT, Orien, Forml(t=-4.122,t=-2.275,t=-2.206,t=-2.927,P<0.05)The diagnostic sensitivity was 95.7%, specificity was 95.5%, positive predictive value was 93.8%, negative predictive value was 97.0%,false negative rate was 4.3%and false positive rate was 4.5%. Conclusion: Light scattering of ultrasound imaging use SDI, HBT, Orien, the Forml four quantitative indicators, qualitative evaluation can reach the masses, has a higher value in the differential diagnosis.

Objective To investigate the risk factors of Gallstone Disease ( GD) by a meta-analy-sis, which hopefully will help to develop a strategy for its prevention .Methods Thirty case-control studies on risk factors of GD in Chinese patients reported from 1987 to 2014 were included .A quantitative compre-hensive analysis and a heterogeneity test were conducted and the OR value and its 95% confidence interval (CI) were calculated by using Stata 12.0.Results A family history of GD [OR(95%CI):2.73(2.22~3.35)], alcohol drinking [OR(95%CI):1.53(1.20~1.97)], a history of biliary tract roundworm [OR (95%CI):5.28(3.10 ~9.00)], a history of biliary tract infection [OR(95%CI): 28.50(19.22 ~42.26 ) ] , a BMI≥25 kg/m2 [ OR ( 95%CI ):1.70 ( 1.51~1.92 ) ] , greasy food intake [ OR ( 95%CI ):3.27(1.76~6.07)], a non-vegetarian diet [OR(95%CI):2.03(1.48~2.77)], hyperlipidemia [OR (95%CI):2.26(1.88~2.71)], menopause [OR(95%CI):3.25(2.49~4.24)] and multiple preg-nancies [OR(95%CI):1.56(1.29~1.88)] were risk factors of GD in China.Besides, milk drinking [OR(95%CI):0.43(0.34~0.55)] and regular breakfast [OR(95%CI):0.19(0.06~0.64)] were protective factors of GD.Tea drinking [OR(95%CI): 0.43(0.34 ~0.55)], smoking [OR(95%CI):0.86(0.51~1.45)], and a vegetarian diet [OR(95%CI):0.24(0.05~1.13)] were possible GD’s protective factors as they were not statistically significant .Conclusion Having breakfast , drinking milk , keeping fit , less alcohol and avoiding Ascaris infection prevent the occurrence of GD in China .

Objective To assess the diagnostic value of susceptibility weighted imaging in intracranial capillary telangiectasia. Methods Clinical and imaging data of 1 3 cases with pathologically proved intracranial telangiectasia were collected.All 1 3 patients were examined with conventional MRI and SWI scanning,five patients were checked with MRA while other six cases were examined by CT scanner,and the results were compared.Results All 13 patients had multiple lesions and a total of 176 lesions were detected by SWI,exhibiting hypointense with possiblely punctate hyperintense in the center .Fifty-two lesions were detected by T1 weighted imaging;105 lesions were detected by T2 weighted imaging;112 lesions were detected by fluid attenuated inversion recovery;69 lesions were detected by diffusion weighted imaging;6 9 lesions were detected by apparent diffusion coefficient.Six cases underwent CT scanning, and one showed multiple low density while the remaining five cases did not find any abnormalities.No cerebral vascular malformation was found in five cases scanned by MRA.The lesions showed round or oval shape,ranging from 3 mm to 17mm in diameter.Among them,98 lesions were located in the pons,39 in cerebellum,23 in cortex,10 in basal ganglia,6 in thalamus.Conclusion SWI is the sensitive sequence to detect intracranial capillary telangiectasia.SWI could be used as the preferred imaging method for intracranial capillary telangiectasia.

Objective To analyze the results of syphilis test and to understand the syphilis infection and its epidemiological characteristics .Methods 728 untreated patients with definite diagnosis of syphilis were enrolled and classified according to their age ,gender and syphilis types ,and retrospectively analysis was conducted .Results Among 728 syphilis patients ,446(61 .26% ) were diagnosed with latent syphilis ,211 (28 .98% ) with dominant syphilis ,32(4 .40% ) with neurosyphilis and 39(5 .36% ) with congenital syphilis .The average detection rate of syphilis was 1 .49% .332(45 .60% ) cases were found in female patients while 396 (54 .40% ) in male .Male syphilis patients were mainly in the 20 to 60 age group ,and female in the 20 to 50 age group .Dominant syphilis occurred mainly in the 20 to 40 age group and latent syphilis in the 20 to 60 age group .Conclusion The detection rate of syphilis increases year by year ,with the highest growing rate in latent syphilis and young adults as major incidence groups .

Objective To analyze the relationship between WT1 gene polymorphism rs16754 and prognosis of acute myeloid leukemia (AML) by meta-analysis. Methods Studies published in PubMed, CNKI, WanFang and CBM database were searched by using the search terms 'WT1', 'Polymorphism' and 'Leukemia, Myeloid, Acute', respectively. Deadline was December 1, 2015. Results A total of 11 English articles with a total of 2 789 patients were included. Meta-analysis showed that there was no association between polymorphism rs16754 and complete remission of AML patients (RR=1.02, 95 % CI: 0.99~1.06, P=0.20), overall survival(OS) (HR=0.68, 95 % CI: 0.45~1.02, P=0.06), 5-year OS (RR=1.10, 95 % CI:0.90~1.34, P=0.37) or relapse-free survival (RFS) (HR=0.80, 95 % CI: 0.54~1.19, P=0.27). Conclusion There is no correlation between WT1 gene polymorphism rs16754 and the prognosis of AML.

005); (3)When sevoflurane concentrations were in the range from 1556?mol/L to 5875?mol/L ,the KD of experimental groups was significantly lower than that of the control (P

Objective To study the effect of benzo(a) pyrene on DNA of human embryonic fibroblast under inhibition of DNA repair,and to explore the mechanism of DNA repair involved in the DNA damage induced by xenobiotic chemical carcinogens. Methods DNA damage of human embryonic lung fibroblast (HELF) induced by benzo(a) pyrene was observed when DNA repair was inhibited by treating HELF with arabinosylcytosin(ara-C) to inhibit the activity of polymerase ?/? in the cells. With S9 mixture added as metabolic activation system in vitro,HELF was treated for 2 hours with ara-C at the doses of 0 and 100 ?mol/L combined with-C at the doses of 0,10,20,50 ?mol/L by the 2?4 factor-factorial analysis.Comet assay was used to assess the DNA damage. Results Compared with the control group,the comet rate and Oliver tail moment of groups treated by B(a)P increased significantly (P

The level of lipid peroxides (LPO)and copper-zinc containing superoxide dismutase(SOD-I) in the gastric mucosa and serum was determined in 141 samples from 25 patients after conventional subtotal gastrectomy (11 cases of Billroth I and 14 cases of Billroth Ⅱ and 11 patients after pylorus and antroseromuscular flap preserving gastrectomy (PAFPG).Those of 11 normal subjects were examined likewise to serve as control.It was found that;1.The average LPO level was much higher and the average SOD-I level much lower in the gastric mucosa after conventional subtotal gastrectomy especially the Billroth type Ⅱ than in those after PAFPG.2.In 36 specimens of stump mucosa,the average LPO level was significantly higher in the tissue around the anastomotic ring than in that of the body of the stump;no marked difference of SOD-I level between the 2 was revealed.3.The LPO value in the stump mucosa was positively correlated to and the SOD-I value negatively correlated to the pH value of gastric juice.Thess findings suggest that the reaction of oxygen free radicals in the stump-mucosa may be influenced by the intragastric pH or by the type of digestive continuity reconstruction,and that the reaction of free radicals specially lipidperoxidation may play a role in the pathogenesis of the lesions in the anastomotic stoma.